Autoantigens for IgA Anti-Intercellular Antibodies of Intercellular IgA Vesiculopustular Dermatosis

Subcorneal Pustular Dermatosis Associated with IgA Myeloma and Intraepidermal IgA Deposits

“…Recently, Ebihara et al [5] examined antigens for the IgA anti-intercellular antibodies in the sera from 3 Japanese patients with SPD-type IAVPD using an immunoblot tech nique. They revealed that sera from all 3 patients bound to neither 140-kD pemphigus vulgaris antigen nor 15()-kD pemphigus foliaceus antigen in the bovine desmosome samples but reacted specifically with a doublet of 115-kD and 105-kD proteins which appeared to be identical to desmocollins I and II.…”

“…Indirect immunofluorescent tests of pa tient's serum samples using normal human skin as a substrate showed IgA-K antibodies reactive with the intercellular space of the upper epi dermis as well as the cytoplasm o f basal cells at a titer of 1:40. Immunoblot analyses using both normal human epidermal extract and bovine desmosome samples as substrates were performed as de scribed previously [5], Although simultaneously tested serum from a previously reported patient with similar clinical and immunopathological features |5] reacted with bovine desmocollin I and II, serum samples from this case did not show any specific reactivity. Oral prednisolone was discontinued due to the lower back pain, and she was started on etretinate at a dosage of 50 mg daily.…”

Two Different Isoforms of Desmocollin Are Recognized by Autoantibodies in Various Types of Pemphigus

“…As we have previously reported [2,9], with immunoblot of a desmosome prepara tion, some sera from all types of pemphigus, particularly BPF, G/A and IAVPD. reacted with a doublet of proteins showing similar migrations as proteins recognized by antiDsc antibodies.…”

IgA-Pemphigus

“…Der pathogenetische Mechanismus besteht in einer Funktionsstörung desmosomaler Adhäsionsmoleküle durch zirkulierende IgA-Autoantikörper.Das Zielantigen beim SPD-Typ des IgA-Pemphigus ist Desmocollin 1 [11,25] und beim IENTyp Desmoglein 1 und 3 [4,13,24].…”