Autogener Meniskusersatz mittels Rippenperichondrium

Bruns, J.; Kampen, Jeroen J. A. van; Kahrs, Johannes; Plitz, W.

doi:10.1007/pl00003709

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…Several materials have been tried, but were not satisfying: Autologous materials [6,7] possess poor initial mechanical characteristics, which makes long term fixation problematic. The calcifications that were found in case of perichondrium [8] and the adaptation to the shape of meniscus of patients also tends to be problematic [9]. An implant based on a donor meniscus seems at first glance an attractive option to replace a severely damaged meniscus [10].…”

Section: Introductionmentioning

confidence: 99%

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Heijkants

Tienen²,

Groot³

et al. 2006

J Mater Sci

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Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane Heijkants, RGJC; Van Tienen, TG; De Groot, JH; Pennings, AJ; Buma, P; Veth, RPH; Schouten, AJ Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. In the past several types of synthetic porous materials have been made as meniscus reconstruction materials. Most of these materials lacked a good combination between suitable mechanical properties and a high interconnectivity. In this work porous scaffolds were made from the polyurethane Estane 5701-F1 by freeze drying of a dioxane and water solution in combination with salt leaching. It was possible to obtain very porous scaffolds with a very high interconnectivity. Porosity, pore size and interconnectivity can be independently adjusted by varying the amount of water, porogen size and the amount of porogen used. The obtained compression moduli of the scaffolds were between 40 kPa and 400 kPa with a variation in porosity between 72 and 87%. These scaffolds are very suitable for the use as meniscus replacement materials. C 2006 Springer Science + Business Media, Inc.

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Section: Introductionmentioning

confidence: 99%

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Heijkants

Tienen²,

Groot³

et al. 2006

J Mater Sci

View full text Add to dashboard Cite

show abstract

“…During the process, a quantity of work has been done such as meniscal transplantation, 20 21 prosthesis substituting, 22 and recently, tissue engineering. 23 Because through tissue engineering, people can desire to mass produce new tissue that mimics native tissue, avoiding injury of donor and risk of infection, tissue engineering became an optimum to reconstruct injured meniscus.…”

Section: Discussionmentioning

confidence: 99%

Applying Electrospun Gelatin/Poly(lactic acid-co-glycolic acid) Bilayered Nanofibers to Fabrication of Meniscal Tissue Engineering Scaffold

Li¹,

Zhang²,

Yu³

et al. 2016

j nanosci nanotechnol

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The menisci are fibrocartilaginous tissues composed primarily of an interlacing network of collagen fibers with nanoscale diameter. Electrospinning is a suitable process of producing nanoscale fibers that mimic collagen fibers. In this study, a bilayered scaffold (group B), which consists of a gelatin nanofiber mesh and a PLGA nanofiber mesh, has been fabricated through an electrospinning method. At the same time, we electrospun pure PLGA fibrous mesh (group A) and gelatin/PLGA composite fibrous mesh (group C) as control groups. In order to compare all scaffold morphologies, the scaffolds were imaged by SEM and some parameters were measured and analyzed as following: Diameters of fibrils are from the smallest of less than average 0.14 μm for group C to the biggest of nearly average 0.38 μm for group B. The scaffolds pore diameters are from average 4.9 μm for group A to average 11.2 μm for group B. Porosity rates show that the group B has the highest porosity rate at about 91%. The scaffolds' properties were compared and analyzed, including hydrophilicity property (water contact angle) and mechanical properties (tensile strength). The results of water contact angle showed the group B is the most hydrophil among the groups. The results of tensile strength showed the tensile strength of group C is the weakest among the groups. All the results showed significant differences between the groups. Finally, in vitro, the meniscal cells derived from New Zealand white rabbits menisci were seeded in the scaffolds. We observed the cells proliferation behavior in the scaffolds. All above demonstrates that a bi-layered gelatin/PLGA scaffold reveals not only concurrent effects of mechanics and cytocompatibility in a fibrous context, but also a promising scaffold for future meniscal repair strategies.

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Autogener Meniskusersatz mittels Rippenperichondrium

Cited by 2 publications

References 28 publications

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane

Applying Electrospun Gelatin/Poly(lactic acid-co-glycolic acid) Bilayered Nanofibers to Fabrication of Meniscal Tissue Engineering Scaffold

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