Autologous Collagen?

Abstract

Intradermal injection of processed fat results in deposition of fibrous material and collagen due to the response of the recipient site. The material itself contains very little collagen.

Experimental structures of antibody/MHC-I complexes reveal details of epitopes overlooked by computational prediction

“…Reactivity of S19.8 with rat b2m has been reported and is consistent with the identity of 13 contact residues (1, 2,4,32,35,36,45,81,82,83,84,89,90) and the similarity of two (85,87). Of note are differences at positions 34, 38, and 88 that may be sufficient to affect the affinity of the interaction.…”

“…The footprint of the Fab V H V L on H2-D d is determined by interactions of 19 residues of the α2 domain (but none of β 2 m), including 17 that contact the Fab H chain and 7 that contact the L chain of which 5 are in common. The buried surface area of the MHC-I chain is 925 Å 2 , of which 714 Å 2 are due to the Fab H chain, and 211 Å 2 to the L chain (see Supplementary Table 2), and the shape complementarity ( S c ( 45 )) between V H V L and H2-D d is 0.637, characteristic of antigen/Ab interfaces. The region of the footprint is illustrated in Fig.…”

Lipofilling of the Lips

“…5 The tissue of the graft site showed proper cells and cellular fragments as a result of a partial necrosis of the injected fat and local reaction to the grafted material located in the same area, perhaps creating fat cysts. In all patients, variable amounts of connective tissue, fat droplets, fat cells, phagocytes, and newly formed vessels were found in the graft material as similarly described by Coleman et al 16 The presence of newly formed vessels indicates that the injected fat is to some extent revascularized, as previously demonstrated in animal models. 17 Extravascular red blood cells found in our material are attributable to hemorrhage at the time of biopsy.…”

Efficacy of Platelet-Rich Plasma Versus Autologous Fat Transfer With Nanofat in the Treatment of Infraorbital Dark Circles: A Single-Blinded Randomized Comparative Clinical Trial

“…The clinical implication of emulsified fat has been extensively studied over the past years. 10,11,14 In addition to its role in treatment of dark circles, nanofat has shown promising results in the management of wide variety of conditions such as joint reconstruction 27,28 and burns, 29,30 which is reasonable given its content of growth factors and stem cells.…”

“…Microfat is then injected with the aim of tissue augmentation. 10 Mechanical emulsification of the aspirated fat between 2 syringes was first described by Coleman and colleagues, 14 to produce a fat-based solution, rich in growth factors, biologic peptides, and stem cells, which is then injected superficially targeting the dermis. The term “nanofat” was introduced the first time by Tonnard and colleagues in 2013, when they added a filtration step using a 500-μm filter after the mechanical emulsification.…”