Autologous peripheral stem cell transplantation for multiple myeloma in a patient with a 10 year-old kidney transplant

A case of successful double sequential bone marrow and kidney transplantations in a patient with multiple myeloma

“…To our knowledge, ours is the fourth reported case of both APSCT and KT in a patient with MM [28][29][30], and the first case of KT following APSCT in MM (Table 1). Our case demonstrates the importance of an aggressive approach to patients with MM, even in patients with impaired kidney function who are often not considered for bone marrow transplantation.…”

Long-term Outcomes of Sequential Hematopoietic Stem Cell Transplantation and Kidney Transplantation: Single-center Experience

“…Experience on autologous HSCT and KT has been described before in case reports, small case series, and most recently in a larger cohort. [30][31][32][33]49 An earlier study by Herrmann et al 32 reported the outcome of 14 patients with AL receiving autologous HSCT (n = 8 KT before autologous HSCT, n = 6 autologous HSCT followed by KT), and patient survival (79%) was not significantly different between groups and all renal allografts were lost due to patient death. The largest experience comes from Angel-Korman et al, 33 who report 49 patients with AL amyloidosis.…”

“…22 To our knowledge, published experience with KT after or simultaneous successful HSCT has only been reported in the literature as small single-center case reports and series. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Our aim was to describe our experience and the outcome of individuals who underwent both KT and HSCT, as well as assess the risk of hematologic disease recurrence in the kidney allograft.…”

Renal allografts in plasma cell myeloma hematopoietic cell graft recipients: on the verge of an explosion?

“…Two other patients had prior renal transplantation followed by PCM 12 years later. 30 Follow-up ranged from 8 months to 15 years from time of first transplant (renal or HCT). Immunosuppression was continued in all patients with tacrolimus, prednisone, mycophenolate, sirolimus and azathioprine in varying combinations.…”