Autologous plasma and serum skin test in chronic urticaria

Asero, Riccardo; Cugno, Massimo; Tedeschi, A.

doi:10.1111/j.1365-2133.2011.10779.x

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…The ASST is a nonspecific screening test that evaluates the presence of serum histamine-releasing factors of any typenot just autoantibodies. According to the experience of many urticaria experts, healthy controls and patients without CSU do not yield a positive ASST [33][34][35][36][37][38][39][40][41]. Nevertheless, the specificity of this test is still a matter of discussion.…”

Section: Diagnosis Of Csu Physical Examination and Complementary Tesmentioning

confidence: 99%

“…Nevertheless, the specificity of this test is still a matter of discussion. The role of coagulation factors in the development of the wheal has been examined using the autologous plasma skin test (APST), but there is still no consensus about that test's use as a diagnostic tool [40,41]. The only way to screen for functional autoantibodies against either IgE or FcɛRI (the high-affinity IgE receptor) is to demonstrate the ability of sera to activate normal basophils, showing either histamine release [42][43][44] or serum-induced basophil CD63 and/or CD203c expression [45,46] by flow cytometry.…”

Section: Diagnosis Of Csu Physical Examination and Complementary Tesmentioning

confidence: 99%

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Management of urticaria: not too complicated, not too simple

Ferrer

Bartra

Giménez‐Arnau

et al. 2015

Clin Experimental Allergy

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In spite of being an old disease and apparently easy to diagnose, chronic spontaneous urticaria (CSU) is still perceived as an uncontrollable and difficult to manage disease. The perception of the patient is that his/her condition is not well understood and that is suffering from a disorder with hidden causes that doctors are not able to tackle. Sometimes patients go through a number of clinicians until they found some CSU expert who is familiar with the disease. It is surprising that myths and believes with no scientific support still persist. Guidelines are not widely implemented, and recent tools to assess severity are infrequently used. European and American recent guidelines do not agree in several key points related to diagnosis and treatment, which further contributes to confusion. With the aim to clarify some aspects of the CSU picture, a group of allergists and dermatologists from the Spanish Dermatology and Allergy societies developed a Frequent Asked Questions leaflet that could facilitate physicians work in daily practice and contribute to a better knowledge of common clinical scenarios related to patients with CSU.

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Section: Diagnosis Of Csu Physical Examination and Complementary Tesmentioning

confidence: 99%

Section: Diagnosis Of Csu Physical Examination and Complementary Tesmentioning

confidence: 99%

Management of urticaria: not too complicated, not too simple

Ferrer

Bartra

Giménez‐Arnau

et al. 2015

Clin Experimental Allergy

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“…Some factors occurring in the course of coagulation may cause false positive results of ASST, thus the specificity of ASST has been controversial in the diagnosis of CAU [ 7 , 16 ]. Therefore, it has been recently suggested that APST may be more sensitive than ASST [ 17 ]. Heparin can inhibit in vivo and in vitro degranulation of mast cells and basophiles, so if plasma is anti-coagulated with heparin, it cannot be used for APST [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The relation of autologous serum and plasma skin test results with urticarial activity score, sex and age in patients with chronic urticaria

Aktar

Akdeniz

Özkol

et al. 2015

pdia

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IntroductionSome previous studies reported autoimmunity as an etiologic factor in chronic urticaria (CU), but the results of some autoimmunity tests in these studies are conflicting.AimTo concretize whether there was any relation of autologous serum skin test (ASST) and autologous plasma skin test (APST) results with sex, age and urticarial activity score (UAS) in patients with CU.Material and methodsFifty patients with CU and twenty healthy subjects admitted to our dermatology clinic were included in the present study. The ASST and APST were applied to all individuals.ResultsThe positiveness rates of ASST and APST were significantly higher in the patient group than controls (p = 0.027, p = 0.001, respectively). Among patients, the APST positiveness rate (72%) was significantly (p < 0.05) higher than ASST (46%). It was seen that 48% of patients with negative ASST results had positive APST. However, no patient with negative APST results had positive ASST. There were significant (p < 0.05) relations of the tests’ positiveness rates with sex and old age but with UAS. The diameter of the erythematous papule was remarkably (p < 0.05) larger in APST than ASST and also significantly (p < 0.05) larger in females compared to males in both tests (p < 0.05). It was positively increased with old age (p < 0.05).ConclusionsWe can suggest that APST is more sensitive than ASST in the assessment of autoimmunity in CU. A high positiveness rate of APST results may be attributed to high numbers of autoantibodies and coagulation factors present in plasma that might probably play a role in etiopathogenesis of CU.

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“…M adam , First of all, we thank Asero et al. 1 for their valuable contributions. We believe that our study is different from previous ones in that it used modified criteria for evaluating the autologous plasma skin test (APST).…”

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confidence: 99%