Autologous Platelet Rich Plasma After Third Molar Surgery: A Comparative Study

Abstract

PRP is an inexpensive and widely available modality to minimize postoperative complication and enhance both hard and soft tissue healing potentials. This autologous product eliminates concern about immunogenic reaction and disease transmission. Its beneficial outcomes in dental clinic, including decrease in bleeding and rapid wound healing hold promise for further procedures.PRP is thus a new application in tissue engineering and developing area for clinician and researchers.

The effect of acemannan sponges in post-extraction socket healing: A randomized trial

“…Therefore, sockets with a bony defect after the surgical removal of lower partially bony impacted third molars present a challenging osseous defect model to use in evaluating the clinical efficiency of biomaterials on bone regeneration [11,12,17,18]. Because of its inorganic composition (60-70%), and location near the socket, alveolar bone is recommended as a reference to assess the radiographic density of the socket and minimize errors during radiographic and image procedures [19,20]. In our study, dentin was used as an internal control.…”

Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region

“…PRP grafted sockets showed dehiscence in 8% of cases. Although probing depth reduced significantly in 3 and 6 months in both the groups, the decrease was greater in PRP grafted sockets [24].…”

“…In 44 (4%) cases, extraction of impacted 3rd mandibular molars resulted in bony periodontal defects on the distal surface of adjacent second molars [24].…”

“…It is a proven source of growth factors like Platelet Derived Growth Factors (PDGF) and Transforming Growth Factors (TGF-ß1-ß2) which is obtained by sequestering and concentrating platelets by gradient density centrifugation. PRP either used alone or in combination with autologous bone or synthetic bone grafts in extraction sockets has been found to improve soft tissue healing, bone regeneration, increase bone density, decrease probing depth and patients experienced less pain following surgery [12][13][14][15][16]. On the contrary, Sanchez et al [17] have pointed out the lack of evidence on the efficacy of PRP in combination with bone grafts during augmentation procedures in a review.…”

“…Inadequate bone healing may result in periodontal defects on the distal side of the adjacent second molar teeth. This complication is more frequent in older patients or when there is already an existing periodontal defect on the distal side of the second molar [15].…”