Autologous tooth graft for maxillary sinus augmentation: A multicenter clinical study

Minetti, Elio; Palermo, Andrea; Contessi, Marcello; Gambardella, Ugo; Schmitz, Johannes; Giacometti, Edoardo; Celko, Martin; Trisi, Paolo

doi:10.4103/gfsc.gfsc_13_19

Cited by 10 publications

(10 citation statements)

References 33 publications

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“…They reported that bone formation was higher with Auto-DDM than with the negative control (empty) and polytetrafluoroethylene membrane. Since then, studies on the regenerative potential of Auto-DDM blocks, including clinical studies involving humans, for guided bone regeneration (GBR), socket preservation (SP), and sinus augmentation have been reported [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The applications of Auto-DDM, as an alternative to autogenous bone grafts, have shown promising clinical and histological results for SP and GBR in implant dentistry owing to its inherent osteoinductive and osteoconductive capacity [ 13 , 14 , 15 , 16 , 17 ]. However, Auto-DDM has limitations despite its proven bone-formation capacity: (1) dependence of the Auto-DDM quantity on the number of teeth indicated for extraction and the condition of the extracted teeth, (2) lack of a standard method to process Auto-DDM, and (3) patient preference.…”

Section: Introductionmentioning

confidence: 99%

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Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity

Lee

Kim

et al. 2021

Materials

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Studies on allogeneic demineralized dentin matrix (Allo-DDM) implantation in the 1960s and 1970s provided the most reliable preclinical evidence of bone formation and antigenicity in an extraosseous site. Recently, applications of Allo-DDM at skeletal sites were studied, and have provided reliable evidence of bone-forming capacity and negligible antigenicity. However, the osteoinductivity and antigenicity properties of Allo-DDM in extraskeletal sites have not yet been investigated due to the lack of follow-up studies after the initial research. The clinical applications of autogenous DDM (Auto-DDM) have been standardized in some countries. Long-term clinical studies have reported the development of several shapes of Auto-DDM, such as powders, blocks, moldable forms, and composites, with recombinant human bone morphogenetic protein-2. For the development of Allo-DDM as a reliable bone graft substitute next to Auto-DDM, we reviewed preclinical studies on the bone induction capacity of allogeneic dentin at extraskeletal as well as skeletal sites. Electronic databases were screened for this review in January 2020 and searched from 1960 to 2019. This review aims to provide a foundation on the preclinical studies of Allo-DDM, which could enable future researches on its osteogenic capability and antigenicity. In conclusion, Allo-DDM showed great potential for osteoinductivity in extraskeletal sites with low antigenicity, which neither adversely affected osteogenic capability nor provoked immunologic reactions. However, the risk of viral disease transmission should be researched before the clinical application of Allo-DDM.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity

Lee

Kim

et al. 2021

Materials

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“…In this study, no inflammatory reaction was observed around the graft, and the tooth material used as graft was perfectly integrated with the host tissue. Unlike other autologous grafts, the tooth matrix does not lose bone volume with the passage of months [ 132 ]. In large bone defects, there is the problem of the amount of grafting that is needed in these cases.…”

Section: Bone Substitutes and Graftmentioning

confidence: 99%

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

et al. 2022

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Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications. Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Results: After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct. Conclusions: The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols.

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“…Recent human study has shown histological and hystomorphometrical high levels of vital bone formation in ASP or maxillary sinus floor augmentation (MSFA) procedures, using autologous demineralized dentin matrix grafts from fresh extracted teeth obtained with a Tooth Transformer innovative device [ 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Implants Survival Rate in Regenerated Sites with Innovative Graft Biomaterials: 1 Year Follow-Up

Minetti

Celko²,

Contessi³

et al. 2021

Materials

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In thirteen different dental clinics in Singapore, Spain, Czech Republic and Italy, 504 patients were selected, and 483 dental implants were placed in maxillary sites after alveolar socket preservation (ASP) procedures with an autologous demineralized tooth extracted as graft material from an innovative Tooth Transformer device was obtained. All procedures used were reported in n°638 Ethical Committee surgical protocol of University of Chieti and approved. After 4 months, at dental implant placing, bone biopsies were performed to evaluate the histologic outcomes, and 12 months after implant loading, global implant survival rate, failure percentage and peri-implant bone loss were detected. After ASP, only 27 post-operative complications were observed and after 4 months, bone biopsy histomorphometric analysis showed a high percentage of bone volume (BV) 43.58 (±12.09), and vital new bone (NB) 32.38 (±17.15) with an absence of inflammation or necrosis areas. Twelve months after loading, only 10 dental implants failed (2.3%), with a 98.2% overall implant survival rate, nine cases showed mucositis (1.8%) and eight showed peri-implantitis (1.6%). At mesial sites, 0.43 mm (±0.83) of bone loss around the implants was detected and 0.23 mm (±0.38) at the distal sites with an average value of 0.37 mm (±0.68) (p > 0.568). Several studies with a longer follow-up will be necessary to confirm the preliminary data observed. However, clinical results seem to suggest that the post-extraction socket preservation procedure using innovative demineralized autologous tooth-derived biomaterial may be a predictable procedure to produce new vital bone able to support dental implant rehabilitation of maxilla edentulous sites.

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Autologous tooth graft for maxillary sinus augmentation: A multicenter clinical study

Cited by 10 publications

References 33 publications

Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity

Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

Implants Survival Rate in Regenerated Sites with Innovative Graft Biomaterials: 1 Year Follow-Up

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