Autologous transfusion recovery of WBC‐reduced high‐concentration platelet concentrates

Abstract

HCPs may be stored 24 hours for high yield, 48 hours for intermediate yield, and up to 5 days for yields less than 1.6 x 10(11) platelets per bag with equivalent to superior recovery and survival of platelets in the autologous transfusion model compared to APCs.

In vivo recovery and survival of apheresis and whole blood‐derived platelets: a paired comparison in healthy volunteers

“…The differences in recoveries (regressed to time 0) and survivals between apheresis and PRP platelets were similar using COST. The mean platelet recovery and survival that we observed for apheresis platelets were lower than those reported by others; 16‐18 however, there exists considerable variability between studies 17‐19 . Although universal standards for platelet recovery and survival are currently lacking, a new standard, based on a comparison with fresh (<24 hours) controls, has been proposed recently for the evaluation of new platelet products 20 —recovery greater than two‐thirds of fresh platelets and survival greater than one‐half of fresh platelets.…”

Platelet activation and residual activation potential during storage of hyperconcentrated platelet products in two different platelet additive solutions

“…Variables reflecting PLT function were tested, such as PLT factor 4, thrombospondin, β‐thromboglobulin, and soluble annexin V. It was found that these products could be successfully stored for 1 to 3 days, depending on yield 10 . Further investigations on apheresis hcPCs stored in plasma at concentrations of 1300 × 10 9 , 2500 × 10 9 , and 3700 × 10 9 per L where functional analyses included glucose consumption, lactate production, expression of P‐selectin, hypotonic shock response, and extent of shape change were carried out in a subsequent study 9 . The conclusion of this study was that hcPCs could be stored for 1 to 5 days depending on yield.…”

“…Eventually, four products were produced from each donor; altogether 14 PLT concentrates in each group. The storage bags were folded in half to decrease the gas exchange rate by reducing the surface area 9,10 and stored horizontally at 20 to 22°C on a flatbed agitator (Helmer Laboratories Inc., Noblesville, IN).…”

Washed and Volume-Reduced Blood Components

“…[89][90][91][92][93] Schoenfeld has evaluated and compared these experimental platelet components. Several studies have shown that platelet collections may be concentrated beyond current standards using new, high-efficiency apheresis collection devices with or without specialized platelet storage solutions.…”