“…Such methods are plentiful on energy targeting (Gundersen, 1988;Briones and Kokossis, 1999a,b), water targeting (Wang and Smith, 1994a,b;Smith, 2005;Hallale and Fraser, 1998;Alva-Argaez et al, 1999;2007a,b;Gunaratnam et al, 2005), and mass-exchange networks (Halwagi, 1997(Halwagi, , 1990a(Halwagi, ,b, 2006(Halwagi, , 2008, but also in reactor and reaction engineering targeting (Halwagi and Srinivas, 1992;Marcoulaki and Kokossis, 1999;Kokossis, 1997, 1998;Kokossis and Floudas, 1990), simple and complex distillation Kokossis, 2001, 2002), solvent design (Papadopoulos and Linke, 2006a, b;Kazantzi et al, 2007, Kazantzi andHalwagi, 2005;Kokossis, 2000, 2001) and reaction-separation systems (Linke and Kokossis, 2003a,b, 2004Kokossis and Floudas, 1991). Instead, literature evidence indicates a predominant use of general flowsheeting technology for techno-economic and case-by-case analysis, using Aspen Plus for instance, as in the work of NREL on bioethanol production (Wooley et al, 1999) and that of Haas et al (2006) for biodiesel.…”