Automated measurement of permeation and dissolution of propranolol HCl tablets using sequential injection analysis

Motz, Stephan A.; Klimundová, Jana; Schaefer, Ulrich F.; Balbach, Stefan; Eichinger, Thomas; Solich, Petr; Lehr, Claus‐Michael

doi:10.1016/j.aca.2006.07.080

Cited by 24 publications

(12 citation statements)

References 20 publications

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“…5,6 A combination of the aforementioned in vitro methods was the following step. Simultaneous determination of dissolution and permeation through Caco-2 can be conducted in two classes of apparatus, open 7,8 and closed 9 systems. The classification depends on the dissolution part of the system, using a flow through cell and a dissolution vessel, respectively.…”

Section: Introductionmentioning

confidence: 99%

IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics

Buch

Holm

Thomassen³

et al. 2010

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics

Buch

Holm

Thomassen³

et al. 2010

Journal of Pharmaceutical Sciences

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“…They have been widely applied in pharmaceutical analysis, 13,14 including a few dedicated to metoprolol 15 and propranolol. [16][17][18][19] Regarding acebutolol, and to our best knowledge, no method based on the use of these techniques has been reported.…”

Section: Introductionmentioning

confidence: 99%

Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Passos¹,

Saraiva²,

Lima³

et al. 2008

J. Braz. Chem. Soc.

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Apresenta-se um sistema mecanizado para a determinação de β-bloqueadores em preparações farmacêuticas. Através da utilização da técnica de Análise de Injeção Sequencial (SIA) foi obtida uma metodologia simples, econômica e versátil, adaptável a todo o tipo de controlo farmacêutico envolvendo estas substâncias. As amostras não necessitam de pré-tratamento devendo apenas ser dissolvidas em ácido antes de serem analisadas. ). O desvio padrão relativo foi inferior a 5 % em todas as determinações. A metodologia foi aplicada em comprimidos, injectáveis e cápsulas de libertação prolongada. Os excipientes que, usualmente, são empregues nas preparações farmacêuticas, não interferem. Os resultados obtidos usando a metodologia proposta foram estatisticamente comparáveis com os obtidos pelos métodos de referência (nível de confiança de 95%). O sistema SIA produz apenas 2,5 mL de efluentes por determinação enquanto que os métodos de referência originam 140 mL.A mechanized system for the determination of β-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 -250 mg L ). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.

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“…After this preliminary testing of the apparatus, the time for quantification was found to be suboptimal. Therefore, the system got automated using sequential injection analysis (SIA) [55], the throughput is increased, and comparison of the results obtained with the automated setup reveal results similar to those from the nonautomated version. The automated setup allows online measurement at the three different sampling ports D, A, and B or partially online analysis in combination with high performance liquid chromatography (HPLC).…”

Section: Approach Of Kataoka Et Almentioning

confidence: 99%

“…The approach of Motz et al [55,56] can be seen as a combination of the approach of Ginski et al [48] (compendial dissolution equipment) and the approach of Kobayashi et al [50] (open dissolution module). The most dominant advantage may be seen in the application of complete dosage forms and the application flow rates resulting in physiologically relevant concentrations.…”

Section: Approach Of Motz Et Almentioning

confidence: 99%

“…However, the device lacks the possibility to add complete dosage forms and the use of compendial dissolution devices would be a more robust approach. [55,56]: In 2006, Motz and coworkers published a dissolution permeation device combining a compendial flow through dissolution cell (apparatus 4, USP) with a flow through permeation cell. In order to connect both, a stream splitter providing appropriate low flow rates for the sheer stress sensitive Caco-2 monolayer was installed.…”

Section: Approach Of Kataoka Et Almentioning

confidence: 99%

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Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations

Motz¹,

Bur²,

Schaefer³

et al.

Drug Absorption Studies

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The following chapter gives an overview of instrumented approaches to investigate the interactions of orally or pulmonary administered formulations with epithelial cell cultures in vitro. The first section is focused on the combined assessment of drug release/dissolution and subsequent absorption/permeation for solid oral dosage forms. Experimental approaches to mimic the complex physiologically surroundings in the gastrointestinal tract are presented as well as combinations of dissolution and permeation apparatus.The second part describes different experimental approaches to simultaneously assess deposition and subsequent absorption of pharmaceutical aerosol formulations, typically by adapting some existing impactor/impinger devices to accommodate pulmonary epithelial cell culture systems. Differences between longtime and low-dose aerosol deposition in environmental toxicology and short time bolus inhalation of pharmaceutical aerosols are elucidated.

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Automated measurement of permeation and dissolution of propranolol HCl tablets using sequential injection analysis

Cited by 24 publications

References 20 publications

IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics

IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics

Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations

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