1956
DOI: 10.1111/j.1749-6632.1956.tb32131.x
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Automatic Screening of Cytological Smears for Cancer: The Instrumentation

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Cited by 54 publications
(19 citation statements)
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“…As with the ThinPrep, red blood cells are lysed by the transport medium. 42 In preclinical trials it did not perform as well as expected and the project was discontinued. The process is shown in Figure 1.1C.…”
Section: Monoprep Pap Testmentioning
confidence: 99%
“…As with the ThinPrep, red blood cells are lysed by the transport medium. 42 In preclinical trials it did not perform as well as expected and the project was discontinued. The process is shown in Figure 1.1C.…”
Section: Monoprep Pap Testmentioning
confidence: 99%
“…The Cytoanalyzer project in the US was the first attempt at building an automated screening device for PAP-smears [10]. The system was based on the concept that cancer cells could be distinguished from normal cells on the basis of nuclear size and optical density.…”
Section: Historical Development Of Automated Screening Systemsmentioning
confidence: 99%
“…The conclusion that there was no ultrastructural difference between benign and malignant cells gave the impetus for cytochemical studies of characteristics of precancerous epithelial cells and malignant cells . Automatic screening of cytological smears, and flow cytometric studies of in vitro and in vivo preparations as well as cytologic smears confirmed that the nuclear abnormalities of cancers are due to increase in the number of abnormal chromosomes . It would be remiss not to point out that many of these advanced technologies were based on the original concepts of Papanicolaou.…”
Section: Introductionmentioning
confidence: 99%