Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Zhang, Yunchao; Tang, Jiayu; Wang, Cheng; Zhang, Qinxiu; Zeng, Anqi; Song, Linjiang

doi:10.1016/j.gendis.2023.04.015

Cited by 15 publications

(5 citation statements)

References 103 publications

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“…THC increased the expression of LC3-II and Beclin-1 which were the core autophagy-related proteins to promote the autophagy degradation of dysfunctional mitochondria in TBI rats. 63,64 Thus, this process reduced the excess ROS produced by damaged mitochondria and protected neuronal cells from oxidative burden. 65 Moreover, THC regulated the expression of FOXO4, Bcl-2-associated X protein (Bax) and the activity of caspase-3 to inhibit oxidative stress and apoptosis in rats with spinal cord injury.…”

Section: Role Of Thc In Neurological Disordersmentioning

confidence: 99%

The role of tetrahydrocurcumin in disease prevention and treatment

Zhou,

Li,

Hua

et al. 2024

Food Funct.

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Section: Role Of Thc In Neurological Disordersmentioning

confidence: 99%

The role of tetrahydrocurcumin in disease prevention and treatment

Zhou,

Li,

Hua

et al. 2024

Food Funct.

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“…The majority of cancer biomarkers used today are proteins or peptides whose alterations in tissue or blood levels indicate the development of the tumor [ 105 ]. But the invasive and uncomfortable nature of biopsy or blood makes it difficult to use.…”

Section: Clinical Applications Of Lncrnas and Wnt/β-catenin Signaling...mentioning

confidence: 99%

Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response

Wu,

Dong,

Yang

et al. 2024

Non-coding RNA Research

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“…Patients with renal cell carcinoma account for more than 95% of the total incidence of kidney cancer and approximately 3%–5% of the total incidence of cancer worldwide. Since RCC is a chemotherapy resistant cancer and surgical intervention often fails to eradicate cancer cells, targeted therapy has become the standard first-line treatment for advanced renal cancer over the past decade, but drug resistance eventually develops in almost all patients ( Makhov et al, 2018 ; Zhang et al, 2024 ).…”

Section: Therapeutic Effects and Mechanisms Of Salidroside In Renal D...mentioning

confidence: 99%

Pharmacological functions of salidroside in renal diseases: facts and perspectives

Liu,

Chen,

Zeng

et al. 2024

Front. Pharmacol.

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Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, and altitude sickness prevention properties. Salidroside, a most active constituent derived from Rhodiola rosea, exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, and anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role of salidroside has burgeoned over the last decade, making it a beneficial option for the prevention and treatment of multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s disease, cardiovascular disease, and more. With its anti-aging and renoprotective effects, in parallel with the inhibition of oxidative stress and inflammation, salidroside holds promise as a potential therapeutic agent for kidney damage. This article provides an overview of the microinflammatory state in kidney disease and discuss the current therapeutic strategies, with a particular focus on highlighting the recent advancements in utilizing salidroside for renal disease. The potential mechanisms of action of salidroside are primarily associated with the regulation of gene and protein expression in glomerular endothelial cells, podocytes, renal tubule cells, renal mesangial cells and renal cell carcinoma cell, including TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, as well as the modulation of AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To the best of our knowledge, this review is the first to comprehensively cover the protective effects of salidroside on diverse renal diseases, and suggests that salidroside has great potential to be developed as a drug for the prevention and treatment of metabolic syndrome, cardiovascular and cerebrovascular diseases and renal complications.

show abstract

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Cited by 15 publications

References 103 publications

The role of tetrahydrocurcumin in disease prevention and treatment

The role of tetrahydrocurcumin in disease prevention and treatment

Crosstalk between lncRNAs and Wnt/β-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response

Pharmacological functions of salidroside in renal diseases: facts and perspectives

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