Autoradiographische Studien zur Jodanreicherung im Auge durch Iontophorese

Hagmüller, K.; Trichtel, F.

doi:10.1159/000303810

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…This model was investigated in previous animal studies and in experiments to determine the iodide penetration into the ocular tissues, especially into the anterior parts of the eye. [33][34][35][36] Even if these animal studies and in vitro data cannot be extrapolated to an in vivo treatment, our clinical results confirm the potential efficacy of this method.…”

Section: Discussionmentioning

confidence: 68%

“…In several studies it was demonstrated that increased amounts of iodide can be transferred into all ocular tissues, especially to the anterior segment, using iontophoresis. [33][34][35][36] Iontophoresis utilises a low current to drive charged molecules across tissue barriers for delivery of therapeutic Abbreviations: BUT, break up time; ROS, reactive oxygen species drug concentrations to the inner eye and to facilitate ion penetration into tissues. 37 Several applications of iontophoresis in experimental and clinical ophthalmology, particularly for the treatment of bacterial or viral infections and inflammations, have been reported.…”

mentioning

confidence: 99%

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Iodide iontophoresis as a treatment for dry eye syndrome

Horwath‐Winter

Schmut²,

Em³

et al. 2005

British Journal of Ophthalmology

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Background/aims: Among the causes related to the development or perpetuation and aggravation of dry eye disease, oxidative reactions may have a role in the pathogenesis of this disorder. Antioxidants, such as iodide, have shown a strong effect in preventing the oxidative damage to constituents of the anterior part of the eye. In this clinical trial the effectiveness of iodide iontophoresis and iodide application without current in moderate to severe dry eye patients was compared. Methods: 16 patients were treated with iodide iontophoresis and 12 patients with iodide application without current for 10 days. Subjective improvement, frequency of artificial tear application, tear function parameters (break up time, Schirmer test without local anaesthesia), vital staining (fluorescein and rose bengal staining) as well as impression cytology of the bulbar conjunctiva were evaluated before treatment, 1 week, 1 month, and 3 months after treatment. Results: A reduction in subjective symptoms, frequency of artificial tear substitute application, and an improvement in certain tear film and ocular surface factors could be observed in both groups. A stronger positive influence was seen after application of iodide with current (iontophoresis), as observed in a distinct improvement in break up time, fluorescein and rose bengal staining, and in a longer duration of this effect compared with the non-current group. No significant change in Schirmer test results and impression cytology were observed in both groups. Conclusions: Iodide iontophoresis has been demonstrated to be a safe and well tolerated method of improving subjective and objective dry eye factors in patients with ocular surface disease.

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Section: Discussionmentioning

confidence: 68%

mentioning

confidence: 99%

Iodide iontophoresis as a treatment for dry eye syndrome

Horwath‐Winter

Schmut²,

Em³

et al. 2005

British Journal of Ophthalmology

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“…Previous studies confirm that the lens (especially the lens core) shows the lowest iodide uptake among all ocular tissues and among all tested kinds of application [7,10,11].…”

Section: Discussionmentioning

confidence: 61%

Iodine Distribution in a Porcine Eye Model following Iontophoresis

Rieger

Winkler²,

Buchberger³

et al. 1995

Ophthalmologica

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Iodine distribution was studied in isolated porcine eyes after iontophoresis using ¹³¹l-labelled solutions and chemical methods. After a 15-min treatment with a therapeutically used iodine brine, the iodine content in the ocular tissues showed the following rank order: cornea > retina > vitreous body > anterior chamber fluid > lens. Replacement of the brine by 0.15 MNal increased the uptake values in a different way, but the same rank order was maintained. The increase was highest in the cornea (5.6-fold) and only about 2-fold in the lens, nevertheless approaching now the level of 10^––⁴ M, a concentration which was regarded as being optimal for the antioxidant effect of I^––. Among the other eye components, the relatively high iodine enrichment of the retina was remarkable. The data are discussed with respect to a possible protective, antioxidative and OH-scavenging efficacy of I and to previous results in the literature concerning iodine uptake in ocular tissues.

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“…In this study we used the modern formation of a iontophoresis apparatus primarily developed for the use on the eye by Pommer und Trichtel [28,30].…”

Section: Iodide Iontophoresismentioning

confidence: 99%

“…Several studies have shown that considerable amounts of iodide can be transferred into all ocular tissues, especially to the anterior segment, using iontophoresis [24,[27][28][29][30], and could improve the antioxidative potential of the tear fluid when applied in this way [20,[31][32][33].…”

Section: Introductionmentioning

confidence: 99%