Avaliação das aderências pós-operatórias em ratos submetidos a peritoniostomia com tela de polipropileno associada à nitrofurazona

Diogo-Filho, Augusto; Lazarini, Bárbara Cunha Mello; Vieira-Junyor, Floriano; Silva, Gisele Juliana; Gomes, Heitor Luiz

doi:10.1590/s0004-28032004000400009

Cited by 13 publications

(13 citation statements)

References 17 publications

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“…Secretion at infection sites were collected from the abdominal cavity, for bacteriological examination. Adherences were classified into six grades according to Diogo-Filho et al 21 : grade 0-absence; grade 1-a reduced number of adherences of fibrous character, easily disintegrated by manipulation; grade 2-firm adherences resistant to manipulation, located between intestinal loops but not involving the abdominal wall; grade 3-firm adherences, resistant to manipulation, between the abdominal wall and an abdominal organ or structure; grade 4-firm adherences, resistant to manipulation, located between the abdominal wall and more than one organ or structure; grade 5-firm adherences, resistant to manipulation, found between loops and between loops and the abdominal wall, showing an enteric fistula.…”

Section: Methodsmentioning

confidence: 99%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p<0.001), and higher in group 4 than in group 3 (p<0.01). CONCLUSION: Peritoneal lavage with a 2% lidocaine saline solution without adrenaline, prevented the mortality of all animals with fecal peritonitis .

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Section: Methodsmentioning

confidence: 99%

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

et al. 2008

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“…It can be used as adjuvant in the healing process of cutaneous wounds, since in addition to the antimicrobial activity, it interferes in the formation of granulation tissue. Its topical use is adequate, since it does not suffer significant absorption through whole or burned skin, nor through the mucosa 14,15 . It is found commercially as an ointment (30mg), at a concentration of 2mg/g.…”

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confidence: 99%

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Martini

Scapini

Collaço

et al. 2016

Rev. Col. Bras. Cir.

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Objectives: to evaluate, histologically and macroscopically, the influence of Copaifera multijuga (Copaíba) oil-resin on the healing process of cutaneous wounds, comparing it with nitrofurazone. Methods: we divided 36 rats into three groups of 12 animals, according to the treatment to be administered. Group SL (control) received saline on the lesion; the Group OIL received topical treatment with Copaíba oil; and the Group NITRO was treated with Nitrofurazone. We inflicted a circular wound of 8mm in diameter on the back of each animal. We subdivided each of the three groups of 12 animals into three subgroups, according to treatment time and euthanasia (7, 14 and 21 days). All animals received the proposed treatment daily. We photographed the lesions for area measurement, as well as for evaluation of macroscopic aspects. We resected and stained the scars to quantify and qualify elastic fibers, collagen, degree of epithelization, neovascularization and inflammation. Results: although the saline solution provided a faster wound closure in its initial phase, after 14 days the wound size of the three groups tested was the same. Levels of inflammation and neovascularization were similar in all three groups. The amount of collagen and elastic fibers was higher in the Nitrofurazone and Copaíba oil groups. Conclusion: in male Wistar rats, Copaifera multijuga oil-resin positively influences the healing process, but it is less effective than nitrofurazone in healing by secondary intention.

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“…In general, adhesions arise from any tissue damage in the first week after injury 17,18 . The healing time or termination of that cell proliferation is dependent on the extent of the lesion and the healing process leads to migration of fibroblasts, macrophages and giant cells.…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

“…The healing time or termination of that cell proliferation is dependent on the extent of the lesion and the healing process leads to migration of fibroblasts, macrophages and giant cells. Fibroblasts promote the initial deposit of fibrin and collagen 18 . The higher tissue injury, the more increased collagen and fibrindeposition, making the peritoneal fibrinolysis and increasing the adhesive capacity of the wound line, progressing to the formation of adhesions 17,18 .…”

Section: Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats

Barbuto

Araújo

Bonomi³

et al. 2015

Rev. Col. Bras. Cir.

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Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene the reconstruction of the abdominal wall with polypropylene mesh in rats mesh in rats mesh in rats mesh in rats mesh in rats Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na Uso da membrana amniótica como cobertura da cavidade abdominal na reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos reconstrução da parede com tela de polipropileno em ratos Objective Objective: to evaluate the efficacy of the amniotic membrane used with polypropylene mesh against the formation of adhesions and its influence on healing. Methods Methods Methods Methods Methods: twenty five female Wistar rats were anesthetized for creating a parietal defect in the anterior abdominal wall. Its correction was made with polypropylene mesh alone and associated with amniotic membrane. In the control group (n=11), the screen was inserted alone. In group A (n=7) we interposed the amniotic membrane between the screen and the abdominal wall. In group B, the amniotic membrane was placed on the mesh, covering it. After seven days, the animals were euthanized for macroscopic and microscopic evaluation of healing. Results Results ResultsResults Results: adhesions were observed in all animals except one in the control group. Severe inflammation was observed in all animals in groups A and B and in three of the control group, with significant difference between them (A and B with p=0.01). Pronounced angiogenic activity was noted in one animal in the control group, six in group A and four in group B, with a significant difference between the control group and group A (p=0.002) and group B (p=0.05). The scar collagen was predominantly mature, except in five animals of the control group, with significant difference between the control group and group A (p=0.05) and group B (p=0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: The amniotic membrane did not alter the formation of adhesions in the first postoperative week. There were also pronounced inflammation, high angiogenic activit...

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Avaliação das aderências pós-operatórias em ratos submetidos a peritoniostomia com tela de polipropileno associada à nitrofurazona

Cited by 13 publications

References 17 publications

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis

Comparative analysis of the effects of Copaifera multijuga oil-resin and nitrofurazona in the cutaneous wound healing process

Use of the amniotic membrane to cover the peritoneal cavity in the reconstruction of the abdominal wall with polypropylene mesh in rats

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