Avaliação do índice de danos permanentes através de SLICC/ACR-DI em pacientes com mais de cinco anos de diagnóstico de lúpus eritematoso sistêmico

Sella, Elaine Marcelina Claudio; Sato, Emília Inoue

doi:10.1590/s0482-50042004000200003

Cited by 1 publication

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“…Em pacientes jovens com LES a osteonecrose tem sido apontada como importante causa de incapacidade física, ocasionando prejuízo da qualidade de vida desses pacientes (15,23) . Osteonecrose foi previamente observada em 4% a 6% dos pacientes com LES em dois estudos brasileiros (24,25) . Uma das possíveis explicações para as diferenças porcentuais das freqüências desta co-morbidade descritas na literatura seria a variabilidade da amostra de pacientes e a gravidade do LES.…”

Section: Avaliação Da Osteonecroseunclassified

Osteonecrose em pacientes com lúpus eritematoso sistêmico

Sella¹,

Carvalho²,

Sato³

2005

Rev. Bras. Reumatol.

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Osteonecrosis is a relatively common complication in systemiclupus erythematosus (SLE) patients. Objective: To evaluate the possible risk factors associated with osteonecrosis in SLE patients. Methods: SLE patients [according to American College of Rheumatology (ACR) criteria] who presented osteonecrosis were included in this study. SLE patients with no symptomatic osteonecrosis constituted the control group. Osteonecrosis was confirmed by radiographic evaluation, bone scintigraphy and/or magnetic resonance imaging. Results: The study group was constituted by 14 SLE patients with osteonecrosis (10 women and 4 men, 64% of them white, 33±13 years old and 120±67 months of disease duration). Sex and time of SLE diagnosis matched patients without osteonecrosis constituted the control group (n=14, 57% of them white, 33±7 years old and 111±54 months of SLE). Systemic lupus international collaborating clinics/ACR damage index for SLE (SLICC/ACR-DI) score was higher in patients with osteonecrosis (4±1) compared with control group (1±1) [p<0.001]. Patients with osteonecrosis had higher number of other musculoskeletal irreversible damage when compared with the control group (29% versus 0, respectively; p=0.034). Digital vasculitis was the variable associated with osteonecrosis (p=0.021). There was no significant association between duration of prednisone use or prednisone cumulative dose and osteonecrosis in patients with regular follow-up at the Institution (p=0.624 and p = 0.806, respectively). Conclusions: Previous history of digital vasculitis was a risk factor for the development of osteonecrosis. Patients with digital vasculitis history had 9 times more risk to present osteonecrosis than patients without previous vasculitis

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Section: Avaliação Da Osteonecroseunclassified