Avenue to X-ray-induced photodynamic therapy of prostatic carcinoma with octahedral molybdenum cluster nanoparticles

Abstract

X-ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nano-particles activated by X-rays. Hence,...

PEGylated poly(lactic-co-glycolic acid) nanoparticles doped with molybdenum-iodide nanoclusters as a promising photodynamic therapy agent against ovarian cancer

“…3,4 In addition these complexes do not suffer from self-quenching of their luminescent properties in the aggregated state like common photosensitizers such as porphyrins, which allows their use at high concentrations in materials. These properties have led to various applications in PDT, [5][6][7][8][9][10][11][12] X-ray induced PDT, [13][14][15][16] or photoinactivation of bacteria. [17][18][19][20] Direct administration of Mo 6 complexes is not pertinent for photodynamic applications owing to their instability in aqueous medium which results in the displacement of apical ligands by water molecule.…”

“…3,4 In addition these complexes do not suffer from self-quenching of their luminescent properties in the aggregated state like common photosensitizers such as porphyrins, which allows their use at high concentrations in materials. These properties have led to various applications in PDT, 5–12 X-ray induced PDT, 13–16 or photoinactivation of bacteria. 17–20…”

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

“…9 This last feature was later confirmed as we demonstrated the ability of Mo 6 clusters to enhance radiation effects in vitro. 11,12 In addition, the possibility to coordinate a wide range of apical ligands allows for targeting specific cellular organelles sensitive to O 2 ( 1 D g ). [13][14][15] In vivo experiments with Mo 6 clusters evidenced their low toxicity with regards to typical concentrations used in RDT.…”

A Neutral Heteroleptic Molybdenum Cluster trans-[{Mo6I8}(py)2I4]

“…Among these properties are (i) bright luminescence in red/near infrared spectral regions (with microsecond lifetimes and high quantum yields) under the excitation of ultraviolet/visible light (up to 550 nm) or X-rays [1][2][3][4][5][6][7][8]; (ii) the efficient photosensitization of the reactive oxygen species generation process (mainly singlet oxygen, 1 O 2 ) [4,[8][9][10]; (iii) high radiopacity due to a high local concentration of heavy atoms in a cluster core [7,11]. Thus, different groups have demonstrated the utilization of cluster complexes individually or as active components of the materials in numerous areas, such as catalytic systems [12][13][14][15][16], liquid crystals [17,18], oxygen sensors [19][20][21][22], solar concentrators [16,23,24], an active layer of solar cells [25,26], bioimaging, photodynamic therapy (PDT) [27][28][29][30][31][32][33], as components of self-sterilizing materials [34][35][36][37], or as radiocontrast agents [11]. The abundance of publ...…”