B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice

Simvastatin ointment, a new treatment for skin inflammatory conditions

“…PCNA is a nuclear protein necessary for DNA synthesis in eukaryotes. Its synthesis and expression is related to the proliferating state of cells, and the level of expression reflects the proliferating activity of cells in tumours and precancerous [10,21]. Thus the quantification of PCNA positive cells confirms that multiple applications of TPA originate increase in proliferating cells in the epidermis and simvastatin 1% and dexamethasone ointments reduced it.…”

“…Thus, PCNA staining is used as an indicator of cell proliferation [10]. In order to determine PCNA positive-cells, ear samples were fixed in ALFAC solution, dehydrated using increasing ethanol concentrations, xylene and embedded in paraffin.…”

“…Individual sections were examined by light microscopy (40Â) to quantitate the immunopositive reaction. The relative numbers of immunohistochemically stained PCNA protein were determined by the ratio of immunostained cells/field using the Image J software (NIH, USA) [10].…”

In vitro and in vivo evaluation of a desonide gel-cream photostabilized with benzophenone-3

“…Thus, our aim was to assess the biological effect of the D-GC and compare its effect with C-GC in a model of croton oilinduced skin inflammation, since it mimics several human skin diseases, such as psoriasis or atopic dermatitis 59,60 . Croton oil contains 12-O-tetradecanoylphorbol-13-acetate (TPA) and other phorbol esters as main irritant agents 61 .…”

Signaling Pathways Coupled to Activation of the Kinin B1 Receptor

“…In cutaneous models of inflammation developed in mice, peptidic and non-peptidic kinin receptor antagonists have been effective in reducing cutaneous neurogenic inflammation (Pietrovski et al, 2009). Recently, Pietrovski et al,(2011) demonstrated that both B1R and B2R participate in the hyperproliferative and inflammatory responses of mouse skin suggesting that the use of kinin receptor antagonists may be useful in the treatment of some skin disorders.…”