Bacillaceae -derived peptide antibiotics since 2000

Fengycins From Bacillus amyloliquefaciens MEP218 Exhibit Antibacterial Activity by Producing Alterations on the Cell Surface of the Pathogens Xanthomonas axonopodis pv. vesicatoria and Pseudomonas aeruginosa PA01

“…Although antifungal activity of CLP has been widely reported (Cawoy et al, 2015), there is less evidence about the effect of these antimicrobials on bacteria. Some authors have attributed to surfactins a moderate antibacterial activity against some pathogenic bacteria, including S. aureus, B. subtilis, S. typhimurium, P. aeruginosa, C. variabilis, and Acinetobacter (Zhao et al, 2018). Iturins have also been indicated as antibacterial compounds.…”

“…Among the broad spectrum of bioactive secondary metabolites produced by the Bacillus subtilis group, the antifungal activity of cyclic lipopeptides (CLP) including the three families, surfactins, iturins and fengycins, have been widely documented (Ongena and Jacques, 2008;Raaijmakers et al, 2010;Cochrane and Vederas, 2016). In addition to antifungal properties, antiviral, anticancer, and antibacterial have also been reported (Ongena and Jacques, 2008;Wu et al, 2017;Zhao et al, 2017Zhao et al, , 2018. The CLP exhibit others plant growth-promoting features desirable for agriculture, for example as a signal inducer of systemic resistance in plants (Ongena et al, 2005;Ongena and Jacques, 2008;Cawoy et al, 2014;Chowdhury et al, 2015).…”

“…The antibacterial activity of CLP against several pathogens such as Corynebacterium variabilis, Acinetobacter, Staphylococcus aureus, B. subtilis, Salmonella typhimurium, Pseudomonas aeruginosa, Enterobacter cloacae and Xanthomonas campestris, among others, has been attributed to iturins and surfactins (Zhao et al, 2018). Fengycins are one of the major types of CLP produced by Bacillus, and activity reports have mainly been restricted to antifungal effects (Ongena and Jacques, 2008;Han et al, 2015;Wu et al, 2015;Cochrane and Vederas, 2016;Lu et al, 2016;Fira et al, 2018).…”

An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice

“…AMPs are important components of the innate and adaptive immune systems to protect organisms from microbial infections 5 , 6 . Moreover, AMPs have been isolated from single-celled microorganisms, plants, invertebrates, amphibians, birds, fish, and mammals, including humans 7 – 10 . Some AMPs have been developed into commercial drugs 11 , 12 or suggested as candidates for new antimicrobial agents 13 .…”

Bacteria From the Multi-Contaminated Tinto River Estuary (SW, Spain) Show High Multi-Resistance to Antibiotics and Point to Paenibacillus spp. as Antibiotic-Resistance-Dissemination Players

“…Also, strains of the same species showed numerous variations in genome sequences with a high rate of recombination, which makes them prone to exchange DNA fragments by horizontal genetic exchange (Xie et al, 2016;Xu et al, 2017). Likewise, several species of the genus produce diverse antibiotic substances (Zhao et al, 2018;Pasari et al, 2019), which could make them players in the shaping of their ecosystems. Furthermore, Paenibacillus genomes have a plethora of genes for adaptation, some of which considered to be acquired by HGT (Xie et al, 2016;Xu et al, 2017).…”