Bacteria-assisted delivery and oxygen production of nano-enzyme for potent radioimmunotherapy of cancer

Ni, Jian; Zhou, Hailin; Gu, Jingyu; Liu, Xinpei; Chen, Jie; Yi, Xuan; Yang, Kai

doi:10.1007/s12274-022-4369-4

Cited by 14 publications

(7 citation statements)

References 48 publications

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“…RT is extensively utilized in the clinical management of several malignancies. [893][894][895] Advanced nanotechnologiesmediated RT induces ICD, [896][897][898] repolarizes or depletes TAMs, 899,900 enhances NK cell function, [901][902][903] promotes DCs antigen presentation, 706,904 and reprograms peripheral neutrophils into APCs, 887,905,906 thereby eliciting an immune response that causes tumors in unirradiated sites to recede and producing in some degree of abscopal effects. However, only a few clinical instances have been documented over time, indicating that RT-mediated abscopal effects fall far short of therapeutic requirements.…”

Section: Nps For Radioimmunotherapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Nps For Radioimmunotherapymentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Moreover, Yang et al combined bacterial therapy and tumor oxygen-dependent radioimmunotherapy by injecting neutrophil-targeted BCNs into bacteria-treated mice to achieve desirable RT efficiency. 108 Inactive albumin was employed to encapsulate CAT and transport it to neutrophils in bacteria-infected tumor tissue. By using neutrophils to generate H 2 O 2 and the subsequent catalysis of nanozymes, easily diffusible oxygen could be generated in situ and spread the entire tumor, boosting hypoxia-relieved RT.…”

Section: Strategies To Improve the Radiotherapy Effect Of Oxygen-gene...mentioning

confidence: 99%

“…77 The integration of hollow polydopamine with Pt NPs (Pt@HP) enabled them to have CAT-like activity and could induce the conversion of endogenous H 2 O 2 to oxygen, decreasing the TME hypoxia. The Pt@HP had a mesoporous shell and large cavity and could load apoptin [100][101][102][103][104][105][106][107][108][109] (AP) and vitipofen (VP) to form AVPt@HP@M. Under the action of X-rays, AVPt@HP@M exerted radiosensitization through various aspects, including alleviation of hypoxia, promotion of tumor apoptosis, and X-ray-induced photodynamic therapy.…”

Section: Cerium-basedmentioning

confidence: 99%

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

Wang

Yao

et al. 2023

J. Mater. Chem. B

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“…Hypoxia, as the result of rapid and uncontrollable proliferation of malignant cancer cells, can cause inefficient generation of reactive oxygen species (ROS) and post-treatment repair of DNA damage, thereby contributing to the resistance of cancers towards photodynamic therapy, chemotherapy and RIT [ 7 – 10 ]. Hypoxia also enables the up-regulation of multiple protective signals or growth factors of cancer cells, thus reducing the tumor-suppressing effect of RIT [ 11 – 14 ]. Therefore, efficiently overcoming hypoxia-induced tumor radio-resistance plays a vital role in elevating the therapeutic index of clinically available radiopharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

A continuously efficient O2-supplying strategy for long-term modulation of hypoxic tumor microenvironment to enhance long-acting radionuclides internal therapy

Li,

Wang,

Shi

et al. 2024

J Nanobiotechnol

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Radionuclides internal radiotherapy (RIT) is a clinically powerful method for cancer treatment, but still poses unsatisfactory therapeutic outcomes due to the hypoxic characteristic of tumor microenvironment (TME). Catalase (CAT) or CAT-like nanomaterials can be used to enzymatically decompose TME endogenous H2O2 to boost TME oxygenation and thus alleviate the hypoxic level within tumors, but their effectiveness is still hindered by the short-lasting of hypoxia relief owing to their poor stability or degradability, thereby failing to match the long therapeutic duration of RIT. Herein, we proposed an innovative strategy of using facet-dependent CAT-like Pd-based two-dimensional (2D) nanoplatforms to continuously enhance RIT. Specifically, rationally designed 2D Pd@Au nanosheets (NSs) enable consistent enzymatic conversion of endogenous H2O2 into O2 to overcome hypoxia-induced RIT resistance. Furthermore, partially coated Au layer afford NIR-II responsiveness and moderate photothermal treatment that augmenting their enzymatic functionality. This approach with dual-effect paves the way for reshaping TME and consequently facilitating the brachytherapy ablation of cancer. Our work offers a significant advancement in the integration of catalytic nanomedicine and nuclear medicine, with the overarching goal of amplifying the clinical benefits of RIT-treated patients. Graphical abstract

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Bacteria-assisted delivery and oxygen production of nano-enzyme for potent radioimmunotherapy of cancer

Cited by 14 publications

References 48 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

A continuously efficient O2-supplying strategy for long-term modulation of hypoxic tumor microenvironment to enhance long-acting radionuclides internal therapy

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