Bacterial flora on the surface of oral squamous cell carcinoma

Čanković, Miloš; Bokor-Bratic, Marija; Loncar, Jovana; Marinoski, Jovan; Ilić, Miroslav

doi:10.2298/aoo1302062c

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…But, continuous exposure to external agents, a sedentary lifestyle and dietary habits can affect the human microbiota in terms of its diverse profile, causing dysbiosis which refers to the alterations in the bacterial composition [3,4]. Dysbiosis in the oral cavity has been linked to various diseases, including cancers [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Identification & correlation of bacterial diversity in oral cancer and long-term tobacco chewers- A case-control pilot study

Sawant

Dugad

Parikh

et al. 2021

Journal of Medical Microbiology

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Introduction. Squamous cell carcinoma is a highly aggressive type of oral cancer (OC). It is the most common cancer among men, and accounts for almost 90 % of all oral cancers in India. Consumption of tobacco is a leading factor contributing to maximum oral cancer incidences as per the WHO. Hypothesis/Gap statement. Researchers reported a direct association of microorganisms with dysbiosis in various oral lesions including oral cancer. However, there is a dearth of information related to compositional changes in the oral microbiome in long-term tobacco chewers and the Indian oral cancer population. Aim. The aim of this study was to identify and correlate the bacterial diversity in the oral cavity of tobacco chewers, patients with oral cancer and healthy subjects in the Indian population. Methods. Oral rinse samples were collected for ten subjects in each group followed by DNA extraction. The variable regions of the bacterial 16S rRNA gene (V6-V8) were amplified, sequenced, processed, and analysed using QIIME2 platform to assess alpha and beta diversity between the study groups. Results. This pilot study showed genus Streptococcus dominated the control group (18.54 %), and the abundance decreased in tobacco and OC group (9.63 and 5.45% respectively); whereas genus Prevotella dominated the tobacco and OC group (21.01 and 26.03% respectively). A shift in abundance of microbiome was observed from control population to oral cancer via the tobacco chewing population. Maximum alpha diversity of oral microbiome was found in Indian tobacco chewers. Beta diversity of tobacco chewers was similar to both the healthy population as well as oral cancer patients suggesting transitioning of the oral microbiome from healthy to oral cancer microbiome via the tobacco chewers microbiome. Conclusion. The data provides evidence of oral bacterial dysbiosis due to tobacco chewing habits that can further lead to progression towards cancer.

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Section: Introductionmentioning

confidence: 99%

Identification & correlation of bacterial diversity in oral cancer and long-term tobacco chewers- A case-control pilot study

Sawant

Dugad

Parikh

et al. 2021

Journal of Medical Microbiology

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“…These were: oropharyngeal region (30%), base of tongue (23%), larynx (15.5%) and soft palate (9%). Milos Canković et al 9 found that most frequent sites of malignancy were floor of the mouth (33.3%), mandibular gingiva (20%), and tongue (13%), while Bhurgri et al 10 reported that in oral malignancy, buccal mucosa (55.9%) was the most frequently affected site which was followed by the tongue (28.4%). Another study explained the tongue (67.4%) as the first frequently affected site, followed by buccal mucosa (7.7%) 8. Oral mucositis, an acute inflammation of the oral mucosa can be induced by radiotherapy in head and neck cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Alteration in Oral Flora and Effect of Mucositis in Head and Neck Cancer Patients Undergoing Chemo-radiotherapy

Maurya¹,

Sen²,

Rastogi³

et al. 2020

J Pure Appl Microbiol

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The main aim of this study is to determine the various types of oral bacteria and yeast. Present in oral flora of head and neck cancer patients at different stages of chemo-radiotherapy, and compare it with the control group (patients with contralateral healthy mucosa). Seventy seven patients with proven history of squamous cell carcinoma were included in the study. The oral mucosa profile was assessed for bacterial manifestations in swab samples from both the sites of the patients. The grade of mucositis was charted out for all patients during the second and third week of radiotherapy. The study revealed that all isolated oral flora showed a non-significant increase during radiotherapy, while there was a decrease in oral flora in post RT. However, E. faecalis showed a non- significant decrease during RT, while Citrobacter showed an increase. Candida albicans showed 83% non- significant decrease post- radiotherapy. When these floras were correlated with grade of mucositis, an insignificant increase in flora was found in G2 and G3 stage of mucositis. In this study, the effect of radiation was evaluated on oral flora of head and neck cancer patients and compared with contralateral healthy mucosa of the patients. Various changes were observed during and after radiation therapy. In patients with head and neck cancer the normal oral flora are replaced by pathogenic flora during radiotherapy, and the latter is responsible for infections in post- radiation phase.

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“…A potential etiology could be ascribed to the organisms in around 15% of oral disease patients without known risk factors. 1 The squamous epithelium of the oral cavity is persistently presented to an assortment of microbial difficulties, at both cell and molecular levels. 2 Bacterial dysbiosis in the adult oral cavity can cause, e.g., gum disease, periodontitis, dental caries (tooth decay), and endodontic abscesses.…”

Section: Introductionmentioning

confidence: 99%

Role of oral microbiome in oral cancer: A review

Johny¹,

Sadiq²,

Anamika³

et al. 2022

ADR

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Oral microbiota is among the most assorted in the human body. In excess of 700 species have been distinguished in the mouth, and new sequencing techniques are permitting us to find significantly more species. The life structures of the oral cavity is not the same as that of other body locales. The oral cavity has mucosal surfaces (the tongue, the buccal mucosa, the gingiva, and the palate), hard tissues (the teeth), and exocrine organ tissue (major and minor salivary organs), all of which present novel elements for microbiota organization. Oral squamous cell carcinoma is quite possibly the most well-known danger and is the main source of dismalness and mortality.

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Bacterial flora on the surface of oral squamous cell carcinoma

Cited by 7 publications

References 12 publications

Identification & correlation of bacterial diversity in oral cancer and long-term tobacco chewers- A case-control pilot study

Identification & correlation of bacterial diversity in oral cancer and long-term tobacco chewers- A case-control pilot study

Alteration in Oral Flora and Effect of Mucositis in Head and Neck Cancer Patients Undergoing Chemo-radiotherapy

Role of oral microbiome in oral cancer: A review

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