Bacterial microenvironment-responsive dual-channel smart imaging-guided on-demand self-regulated photodynamic/chemodynamic synergistic sterilization and wound healing

Abstract

Bacterial infections pose a serious threat to public health. The integration of photodynamic therapy (PDT) and chemodynamic therapy (CDT) has emerged as a promising means to combat bacterial infection. However,...

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

“…Bacterial infection, which causes serious diseases (e.g., prematurity or stillbirth during pregnancy) and rising mortality, poses a main threat to global public health. − In order to achieve efficient therapeutic intervention, integration of chemodynamic therapy (CDT) and PDT has emerged as a useful approach to combat the bacterial infections. − Toward this purpose, it is necessary to develop a bacteria-specific activated synergistic therapy platform for precise sterilization. Yan et al, very recently, presented bacterial microenvironment-driven dual-channel smart imaging based on visible room-temperature phosphorescence and near-infrared fluorescence, which guided on-demand self-controlled PDT and CDT for precise antibacterial activity and wound healing. The acid-degradable persistent Zn 2 GeO 4 :Mn nanoparticles with good biocompatibility were constructed to perform two main biological functions: bacterial environment-sensitive phosphorescence imaging and acting as a acid/H 2 O 2 dual-stimulus-relevant agent for CDT.…”

“…514−516 Toward this purpose, it is necessary to develop a bacteria-specific activated synergistic therapy platform for precise sterilization. Yan et al, 517 very recently, presented bacterial microenvironment-driven dual-channel smart imaging based on visible room-temperature phosphorescence and near-infrared fluorescence, which guided ondemand self-controlled PDT and CDT for precise antibacterial activity and wound healing. The acid-degradable persistent Zn 2 GeO 4 :Mn nanoparticles with good biocompatibility were constructed to perform two main biological functions: bacterial environment-sensitive phosphorescence imaging and acting as a acid/H 2 O 2 dual-stimulus-relevant agent for CDT.…”

“…(b) Phosphorescent and (c) fluorescent imaging of wounds in mice under different treatments. Reprinted with permission from ref . Copyright 2022 Royal Society of Chemistry.…”

Infection Microenvironment-Mediated Nanoplatform for In Vivo Persistent Luminescence Imaging and Chemodynamic Antibacterial Therapy

“…Hence, it is urgently needed to explore advanced antibacterial agents and robust approaches to solve this problem . Recently, many nanotechnology-based antibacterial approaches have been applied for anti-infective treatment, including photothermal therapy (PTT), chemodynamic therapy (CDT), sonodynamic therapy (SDT), and photodynamic therapy (PDT). − CDT is a promising antibacterial approach due to high therapeutic specificity and low invasiveness. − It can in situ convert intracellular H 2 O 2 to highly cytotoxic hydroxyl radicals ( • OH) via Fenton-like reaction. , Recently, CDT activated by the infection microenvironment has achieved great progress in the treatment of bacterial infections. − …”

pH-Responsive and Chemiluminescent Carboxyethyl Chitosan Nanocarriers for Intelligent Targeted Phototherapy Sterilization

“…Phototherapy is a local treatment method in which appropriate light source stimulation and precision imaging are crucial. Imaging guidance can accurately locate the lesion site to determine the best irradiation site of light source, monitor the treatment status of the infected site in real time, adjust the treatment plan in time, and reduce unnecessary side effects. − However, most of the existing imaging strategies require continuous in situ irradiation, resulting in background fluorescence interference and false positive results, as well as non-specific thermal damage. − Thus, the development of bacteria-specific, responsive, and self-luminous imaging system is of great significance for further improving the signal-to-noise ratio and reducing non-specific damage. Bis­[3,4,6-trichloro-2-(pentyloxycarbonyl)­phenyl] oxalate (CPPO), a hydrophobic peroxyoxalate, can be selectively and rapidly decomposed into a high-energy intermediate (dioxetanedione) in the presence of H 2 O 2 .…”