Bacterial Vaginosis and Desquamative Inflammatory Vaginitis

Giovanini, Allan Fernando; Lobas, Amanda; Reisdoerfer, Gisele

doi:10.1056/nejmc1900134

Cited by 7 publications

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, changes in vaginal microbiota have been associated with bacterial vaginosis and in the skin with psoriasis, acne, and rosacea. 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

The Ocular Microbiome Is Altered by Sampling Modality and Age

Katzka

Dong

Luu

et al. 2021

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Background Studies of the ocular microbiome have used a variety of sampling techniques, but no study has directly compared different sampling methods applied to the same eyes to one another or to a reference standard of corneal epithelial biopsy. We addressed this lack by comparing the microbiome from three conjunctival swabs with those of corneal epithelial biopsy. Methods Twelve eyes (11 patients) were swabbed by calcium alginate swab, cotton-tipped applicator, and Weck-Cel cellulose sponge before a corneal epithelial biopsy (48 samples). We then performed 16S rRNA gene sequencing and universal 16S rRNA gene real-time polymerase chain reaction. Negative/blank controls were used to eliminate contaminants. An analysis was performed to examine the concordance of the three swab types to corneal epithelial biopsy. The effect of patient age on the ocular microbiome as determined by epithelial biopsy was also examined. Results The ocular microbiome from corneal epithelial biopsies consisted of 31 genera with a relative abundance of 1% or more, including Weisella , Corynebacterium , and Pseudomonas. Of the three swab types, Weck-Cel differed the most from corneal biopsies based on beta-diversity analysis. Cotton swabs were unable to capture the Bacteroides population seen on epithelial biopsy. Therefore, calcium alginate swabs seemed to be the closest to epithelial biopsies. Older patients (≥65 years old) had higher alpha diversity ( P < 0.05) than younger patients. Differential abundance testing showed that there were 18 genera that were differentially abundant between the two age groups, including Streptococcus and eight members of the Proteobacteria phylum. Conclusions We demonstrate that ocular sampling method and patient age can greatly affect the outcome of sequencing-based analysis of the ocular microbiome. Translational Relevance By understanding the impact of different sampling methods on the results obtained from the ocular surface microbiome, future research on the topic will be more reproducible, leading to a better understanding of ocular surface microbiome in health and disease.

show abstract

“…For example, changes in vaginal microbiota have been associated with bacterial vaginosis and in the skin with psoriasis, acne, and rosacea. 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

The Ocular Microbiome Is Altered by Sampling Modality and Age

Katzka

Dong

Luu

et al. 2021

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

show abstract

“…Vulvovaginitis is an inflammatory disease of the vulva and vaginal tissues caused by pathogenic infections such as bacteria, fungi, and viruses, and it is a common condition that damage women’s physical and psychological health ( 1 ). Clinical symptoms usually include pruritus, pain, dysuria, ulcerations, increased vaginal secretions, and odor ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

The risk factors for negative emotions in parents of children with bacterian vulvovaginitis and its impact on prognosis: a retrospective cohort study

Xie¹,

He²

2023

Transl Pediatr

View full text Add to dashboard Cite

Background: Vulvovaginitis is one of the most common pediatric gynecological diseases and easily causes the negative emotions for the parents. However, there are few studies on the influence of parental anxiety and depression on children's disease and prognosis. This study aimed to analyze the risk factors of negative parental emotions and their effects on the prognosis of children, in order to improve life quality of children. Methods:We retrospectively analyzed 303 pediatric patients who developed bacterian vulvovaginitis from April 2017 to April 2022 based on our inclusion and exclusion criteria. The Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS) were used to assess the negative emotions and binary logistic regression was used to analyze the independent risk factors for negative emotions among the parents of children with vulvovaginitis. The relationship between the prognosis of children and parents' negative emotions was analyzed by independent sample t-test, and the relationship between the recovery rate of children within 2 weeks, clearance rate of urine, and parents' negative emotions was analyzed by chi-square test.Results: In our study, 44.6% of the parents showed anxiety and 35.0% showed depression. The binary logistics regression of the clinical characteristics of the children showed that vulvar pruritus [odds ratio (OR) =1.664, P=0.048], increased vaginal secretions (OR =2.289, P=0.001), vulvar ulcerations (OR =1.831, P=0.024), and so on were independent influences on the anxiety of the parents, whereas vulvar pruritus (OR =2.722, P=0.000), increased vaginal secretions (OR =1.758, P=0.041), dysuria, frequent urination (OR =1.761, P=0.040), and so on were independent influences on depression among the parents. Besides, it was found that parental negative emotions significantly prolonged the improvement of the child's prognosis.Conclusions: Parents of children with vulvovaginitis are highly susceptible to have negative emotions due to the various clinical features of the child. The negative emotions of the parents significantly prolong the recovery time of the child. In clinical practice, adequate communication should be established with the parents of patients, and detailed education should be carried out to reduce the psychological burden of patients' parents, so as to improve the prognosis of children.

show abstract

“…Bacterial vaginosis occurs when there is a change in the vaginal microbiota, due to the decrease in Lactobacillus spp., and a predominance of anaerobic microorganisms (3) . Lactobacillus spp., through RESUMO Introdução: A vaginose bacteriana é a causa mais comum de corrimento vaginal e ocorre quando há um desequilíbrio da microbiota vaginal, composta predominantemente de Lactobacillus spp.…”

Section: Introductionunclassified

“…the production of hydrogen peroxide (H2O2) and lactic acid, maintain the acidic vaginal pH, thus preventing the excessive proliferation of Gardnerella vaginalis and other anaerobic bacteria that cause bacterial vaginosis (3) . Studies suggest that bacterial vaginosis is a cofactor for the acquisition and persistence of cervical infection by HPV (4)(5)(6) and, as a result, also a risk factor for the cytological abnormalities induced by this viral infection (5)(6)(7) .…”

mentioning

confidence: 99%

Bacterial vaginosis, cervical Human Papillomavirus infection and cervical cytological abnormalities in adult women in Central Brazil: A cross-sectional study

Martins

Camargo

Lima

et al. 2022

J Bras Doenças Sex Transm

View full text Add to dashboard Cite

Introduction: Bacterial vaginosis is the most common cause of vaginal discharge and occurs when there is an imbalance in the vaginal microbiota, predominantly composed of Lactobacillus spp. Human Papillomavirus is the most common sexually transmitted virus in the world. Persistent infection with high-risk Human Papillomavirus genotypes is the main cause of the development of cervical intraepithelial neoplasia and cervical cancer. Objective: To investigate the association between bacterial vaginosis and cervical Human Papillomavirus infection and between bacterial vaginosis and cervical cytological abnormalities in adult women. Methods: Cross-sectional study carried out in a gynecology outpatient clinic of the public health network. A total of 202 women were included in the study and underwent gynecological examination with cervical specimen collection. Cervical cytopathological examinations and bacterioscopy by the Nugent method were performed to identify bacterial vaginosis, and PCR and reverse hybridization were carried out for Human Papillomavirus detection and genotyping. Bivariate analysis was performed to investigate the association between bacterial vaginosis and cervical Human Papillomavirus infection, and between bacterial vaginosis and cervical cytological abnormalities. The odds ratio was calculated, with the respective 95% confidence intervals (95%CI) and 5% significance level (p≤0.05). Results: The prevalence of bacterial vaginosis was 33.2% (67/202), the prevalence of cervical Human Papillomavirus infection was 38.6% (78/202) and the prevalence of cervical cytological abnormalities was 6.0% (12/202). Bivariate analysis showed no significant association between bacterial vaginosis and cervical Human Papillomavirus infection (OR 0.69; 95% CI 0.37–1.27; p=0.23), or between bacterial vaginosis and cervical cytological abnormalities (OR 0.65; 95%CI 0.17–2.50; p=0.54). Conclusion: In this study, bacterial vaginosis did not represent a risk factor for cervical Human Papillomavirus infection or for the presence of cervical cytological abnormalities in the investigated adult women.

show abstract

Bacterial Vaginosis and Desquamative Inflammatory Vaginitis

Cited by 7 publications

References 3 publications

The Ocular Microbiome Is Altered by Sampling Modality and Age

The Ocular Microbiome Is Altered by Sampling Modality and Age

The risk factors for negative emotions in parents of children with bacterian vulvovaginitis and its impact on prognosis: a retrospective cohort study

Bacterial vaginosis, cervical Human Papillomavirus infection and cervical cytological abnormalities in adult women in Central Brazil: A cross-sectional study

Contact Info

Product

Resources

About