Bactericidal Properties of Plants-Derived Metal and Metal Oxide Nanoparticles (NPs)

Teow, Sin-Yeang; Wong, Magdelyn Mei Theing; Yap, Hooi Yeen; Peh, Suat‐Cheng; Shameli, Kamyar

doi:10.3390/molecules23061366

Cited by 42 publications

(20 citation statements)

References 173 publications

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“…20 Zinc oxide NPs (ZnO-NPs) are a common type of zinc-containing nanoparticles that have gained increasing attention in biological research because of their low toxicity, biological compatibility, bioactivity, and chemical stability. 21 ZnO-NPs can accelerate bone growth and mineralization. 22 In addition, they possess selective toxicity toward bacteria and normal cells.…”

Section: Introductionmentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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Section: Introductionmentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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“…In the past, 60 types of xanthones had been isolated from the GM pericarp [17]. Similarly, GM has also been associated with other pharmacological actions such as antitumor, antibacterial, antifungal and antiviral activities [12,13,14,18,19]. Mechanisms of anticancer xanthones have previously been revealed, including induction of apoptosis through regular cell death pathways, suppression of cell proliferation, and inhibition of metastasis by blocking the anti-apoptotic molecules and cell cycle arrest [20].…”

Section: Introductionmentioning

confidence: 99%

Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action

et al. 2019

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Discovery of a potent drug nanocarrier is crucial for cancer therapy in which drugs often face challenges in penetrating efficiently into solid tumours. Here, biosynthesis of silver nanoparticles (AgNPs) using a waste material, Garcinia mangostana (GM) fruit peel extract is demonstrated. The best condition for AgNPs synthesis was with 0.5 g of peel extract, 7.5 mM silver nitrate at 45 °C, ~pH 4 for 16 h. The synthesized AgNPs were spherical and 32.7 ± 5.7 nm in size. To test its efficiency to be used as drug carrier, plant-based drug, protocatechuic acid (PCA) was used as a test drug. AgNPs loaded with PCA (AgPCA) resulted in 80% of inhibition at 15.6 µg/mL as compared to AgNPs which only killed 5% of HCT116 colorectal cells at same concentration. The IC50 of AgNPs and AgPCA for HCT116 were 40.2 and 10.7 µg/mL, respectively. At 15.6 µg/mL, AgPCA was not toxic to the tested colon normal cells, CCD112. Ag-based drug carrier could also potentially reduce the toxicity of loaded drug as the IC50 of PCA alone (148.1 µg/mL) was higher than IC50 of AgPCA (10.7 µg/mL) against HCT116. Further, 24-h treatment of 15.6 µg/mL AgPCA resulted in loss of membrane potential in the mitochondria of HCT116 cells and increased level of reaction oxygen species (ROS). These could be the cellular killing mechanisms of AgPCA. Collectively, our findings show the synergistic anticancer activity of AgNPs and PCA, and its potential to be used as a potent anticancer drug nanocarrier.

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“…Metal oxide nanoparticles (MO-NPs), such as zinc oxide, gold or silver nanoparticles [93][94][95], are another very promising RONS-producing antibiotherapeutic strategy that could be used in combination with other RONS-generating compounds ( Figure 4A). Despite of the fact that there are numerous studies demonstrating the antibacterial role of metal oxide nanoparticles [93,96], their mechanism of action based on RONS-production is still not fully understood. In many occasions, their RONS-based antimicrobial activity is activated by light.…”

Section: Rons-producing Anti-infectives Are An Attractive Strategy Tomentioning

confidence: 99%

Oxidative Stress-Generating Antimicrobials, a Novel Strategy to Overcome Antibacterial Resistance

et al. 2020

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Antimicrobial resistance is becoming one of the most important human health issues. Accordingly, the research focused on finding new antibiotherapeutic strategies is again becoming a priority for governments and major funding bodies. The development of treatments based on the generation of oxidative stress with the aim to disrupt the redox defenses of bacterial pathogens is an important strategy that has gained interest in recent years. This approach is allowing the identification of antimicrobials with repurposing potential that could be part of combinatorial chemotherapies designed to treat infections caused by recalcitrant bacterial pathogens. In addition, there have been important advances in the identification of novel plant and bacterial secondary metabolites that may generate oxidative stress as part of their antibacterial mechanism of action. Here, we revised the current status of this emerging field, focusing in particular on novel oxidative stress-generating compounds with the potential to treat infections caused by intracellular bacterial pathogens.

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Bactericidal Properties of Plants-Derived Metal and Metal Oxide Nanoparticles (NPs)

Cited by 42 publications

References 173 publications

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action

Oxidative Stress-Generating Antimicrobials, a Novel Strategy to Overcome Antibacterial Resistance

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