Bacteriology of the Middle Meatus Aspirate in Patients with Cystic Fibrosis

Franche, Guilherme Luis da Silva; Silva, Fernando Abreu e; Saleh, Cátia de Souza

doi:10.1016/s1808-8694(15)30100-2

Cited by 8 publications

References 18 publications

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Staphylococcus aureusin early cystic fibrosis lung disease

2013

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Staphylococcus aureus: is a common bacterial organism infecting children with cystic fibrosis (CF). Emerging evidence suggests early lower airway infection with this organism in young children with CF results in the deterioration of lung function, poorer nutrition parameters and heightens the airway inflammatory response. Despite contributing significantly to the burden of early lung disease among this group, there are ongoing controversies in the management of S. aureus infection, and gaps in our understanding of exactly how this organism causes lung disease. To reduce the morbidity and mortality of early infection ongoing research is needed to: (i) understand the early host immune response that enables this pathogen to reside within the CF lung; (ii) determine if there are organism specific factors that are associated with CF lung disease; and (iii) clarify the utility of anti-staphylococcal antibiotic prophylaxis and/or eradication in the treatment of this patient population.

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Staphylococcus aureusin early cystic fibrosis lung disease

2013

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Nasal and Paranasal Sinus Infections in Children with Cystic Fibrosis

Resuli¹,

Cingi²,

Scadding³

2021

Pediatric ENT Infections

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Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia – Brazil

Tunes¹,

Reis²,

Terse³

et al. 2014

The Brazilian Journal of Infectious Diseases

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Lower airway infection is a major cause of morbidity and mortality in patients with cystic fibrosis. It is currently unknown if the infection of the upper airway can cause exacerbation of lower respiratory tract infection. This study aimed to determine the microbiological profile of the anterior paranasal sinuses outflow tract (middle meatus) of cystic fibrosis outpatients. The microbiological profile was defined using endoscopically directed middle meatal cultures. Paired middle meatal and sputum specimens were collected from 56 outpatients for aerobic cultures. A semi-quantitative leukocyte count of the middle meatal samples was performed. The median age of patients was nine years (3-20 years). Staphylococcus aureus (37%), Staphylococcus coagulase-negative (25%), Neisseriac (14%), Pseudomonas aeruginosa (11%), and Streptococcus pneumoniae (7%) were the most prevalent microorganisms in the middle meatal cultures. Using the middle meatal leukocyte count, 16 out of 54 patients (29.6%) presented sinus infection. The most frequently identified pathogens in patients with sinus infections were Staphylococcus aureus (10 patients), Pseudomonas aeruginosa (4 patients), and Streptococcus pneumoniae (3 patients). Agreement of paired middle meatal and sputum cultures was significantly higher among patients with infection in middle meatal (69%). The most common middle meatal pathogens were the typical cystic fibrosis spectrum. This suggests the potential for participating in post-nasal lower airway seeding.

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Bacteriology of the Middle Meatus Aspirate in Patients with Cystic Fibrosis

Cited by 8 publications

References 18 publications

Staphylococcus aureusin early cystic fibrosis lung disease

Staphylococcus aureusin early cystic fibrosis lung disease

Nasal and Paranasal Sinus Infections in Children with Cystic Fibrosis

Microbiology of the middle meatus compared to sputum in young patients with cystic fibrosis from Bahia – Brazil

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