Baicalin prevents cadmium induced hepatic cytotoxicity, oxidative stress and histomorphometric alterations

Proteomics approach to analyze protein profiling related with ADME/Tox in rat treated with Scutellariae radix and Coptidis rhizoma as well as their compatibility

“…Recent studies have shown that the flavonoids in S. radix and berberine in C. rhizoma both have antioxidant activity and lipid peroxidation preventive effect. After administrating S. radix or C. rhizoma, the activity of GPX in rats was increased (Wen et al, 2013;Zhou and Zhou, 2011). The results in this study matched this finding.…”

“…GST can protect the cells from the damage by reactive oxygen species. Recent studies found that the content of GST was increased in diseased liver tissues and serums (Wen et al, 2013). This finding contributes to the diagnosis, treatment and prevention of the hepatic diseases, and may be a new sensitive indicator of liver cancer.…”

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

“…Cd decreases CAT levels to accumulate free radicals, which in turn inhibits CAT activity. Cd also increases cell vulnerability after GSH depletion . The body increases GSH synthesis to neutralize reactive oxygen species (ROS) or to bind Cd .…”

Baicalin attenuates proinflammatory cytokine production in oxygen–glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway

“…Baicalin (Fig. 1), a flavonoid compound isolated from Scutellariae radix, has been shown to possess a number of pharmacological effects including anti-infection, anti-inflammatory, antioxidant and immune regulation [5][6][7][8]. Recently, numerous studies have focused on the therapeutic effect of baicalin on brain diseases, especially ischemic cerebral vascular disease.…”