Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats

Ying, Changjiang; Mao, Yizhen; Chen, Lei; Wang, Shanshan; Ling, Hongwei; Li, Wei; Zhou, Xiaoyan

doi:10.1016/j.ijbiomac.2017.03.124

Cited by 45 publications

(31 citation statements)

References 27 publications

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“…The usefulness of the natural sources is not limited to oncology. Bamboo leaf extract administered for a period of 12 weeks to diabetic rats has been shown to improve body weight and biochemical markers, and to alleviated renal injury by increasing p-Akt levels ( 144 , 145 ). Similar properties were observed for sea buckthorn fruit oil extract and the traditional Chinese medicine Liuwei Dihaung ( 146 , 147 ).…”

Section: Natural Products Targeting the Akt Pathwaymentioning

confidence: 99%

The Akt pathway in oncology therapy and beyond (Review)

et al. 2018

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Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and division, apoptosis suppression and angiogenesis. Akt protein kinase displays important metabolic effects, among which are glucose uptake in muscle and fat cells or the suppression of neuronal cell death. Disruptions in the Akt-regulated pathways are associated with cancer, diabetes, cardiovascular and neurological diseases. The regulation of the Akt signaling pathway renders Akt a valuable therapeutic target. The discovery process of Akt inhibitors using various strategies has led to the identification of inhibitors with great selectivity, low side-effects and toxicity. The usefulness of Akt emerges beyond cancer therapy and extends to other major diseases, such as diabetes, heart diseases, or neurodegeneration. This review presents key features of Akt structure and functions, and presents the progress of Akt inhibitors in regards to drug development, and their preclinical and clinical activity in regards to therapeutic efficacy and safety for patients.

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Section: Natural Products Targeting the Akt Pathwaymentioning

confidence: 99%

The Akt pathway in oncology therapy and beyond (Review)

et al. 2018

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“…In addition, the leaf and root extracts of bamboo exerted inhibitory effects on growth of groundnut and corn seedlings [15,16]. The pharmacological properties, including anti-inflammatory, anticancer, and antibacterial activities of bamboo have been described [12,17]. From this evidence, it is proposed that bamboo leaf may possess potent antifungal activity and may be successfully applied in the management of plant pathogens.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Bamboo Leaf on the Growth of Pyricularia grisea Fungus

Toan

Xuan

et al. 2018

Agriculture

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Abstract:In this study, the effects of bamboo leaf were examined on mycelial growth of Pyricularia grisea, a fungus of rice blast disease that causes a great loss in rice production. The hexane extract exhibited maximal reduction on growth of P. grisea (IC 50 = 0.62 mg/mL), followed by aqueous and ethyl acetate extracts, while the methanol extract was least effective (IC 50 = 9.71 mg/mL). At 0.5-1.0 mg/mL doses, all extracting solvents showed inhibition on the growth of P. grisea, but at a 0.1 mg/mL concentration, the antifungal activity was solely observed on hexane and ethyl acetate extracts. By GC-MS (gas chromatography-mass spectrometry), 25 constituents were identified, principally belonging to long-chain fatty acids, sterols, phenols, phenolic acids, volatile oils, and derivatives of terpenes. It was suggested that compounds originated from hexane and ethyl acetate extracts such as fatty acids, oils, and phenols, and their derivatives were responsible for the antifungal activity of bamboo leaf. Non-polar constituents were accountable for the antifungal activity, although water-soluble compounds may play a role. Bamboo leaf appears to be a potent natural source to manage the infestation of P. grisea in rice cultivation.

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“…Mango leaf extract affects glucose and lipid homeostasis in vitro and in vivo through the PI3K/ Akt and Adenosine monophosphate-activated protein kinase (AMPK) signaling pathways (19). Bamboo leaf extract treatment could increase the phosphorylated Akt level in renal tissues of rats with diabetes (20). Therefore, insulin-like activity, such as the stimulation of glucose uptake by skeletal muscle through PI3K/Akt pathways, may be crucial in regulating blood glucose level.…”

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confidence: 99%