Banking and use of glycerol preserved full-thickness skin allograft harvested from body contouring procedures

Zidan, Serag M.; Eleowa, Samy

doi:10.1016/j.burns.2013.08.039

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…Of these methods, glycerol preservation has the advantage of simplicity and low cost. Glycerol also has antibacterial and antiviral activity giving it additional advantage [26]. The efficacy of antibacterial and antiviral properties of glycerol is directly proportionate to the concentration of glycerol and the initial storage temperature [27,28].…”

Section: Introductionmentioning

confidence: 99%

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Zidan

Eleowa

Nasef

et al. 2015

Burns

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Section: Introductionmentioning

confidence: 99%

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Zidan

Eleowa

Nasef

et al. 2015

Burns

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“…The challenges are reported in Nepal with human skin allografts, where mortality for burn patients with total body surface area (TBSA) over 40% was almost 100% of included limitation of donors. [ 42 ] This has alluded to various factors such as the fact that it was against the general Hindu belief which values the wholeness of the body after death, the need to have the family consent even if the patient gave consent, also people prefer to die at home than in the hospital, making procurement more challenging.…”

Section: Resultsmentioning

confidence: 99%

Glycerolised Skin Allografts for Extensive Burns in Low- and Middle-income Countries

Iyun

Ademola

Olawoye

et al. 2021

Journal of West African College of Surgeons

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Introduction: There has been a significant improvement in the outcome of treatment of large surface area burns in developed countries. A major contributory factor is an early excision and skin grafting of burn wounds. The initial coverage of large surface area deep burn wounds requires the use of temporary skin substitutes such as allografts due to limited skin autografts. Cadaveric skin allografts are the commonest source of skin allografts in use; however, there may be religious, cultural, cost, or other factors mitigating its availability and routine use in low- and middle-income countries (LMICs). Human skin allografts may be used fresh or stored in tissue banks to ensure its ready availability. The purpose of this review is to promote glycerolised skin allografts as a means of skin preservation in low-resource countries above other modalities cryopreservation due to its cost advantages and relative ease of operation. Materials and Methods: A literature search for articles related to human skin allograft use in burn care, skin banks, and glycerolised skin allografts in LMICs was done using PubMed, EMBASE, and Web of Science databases. The key words used were ‘allograft’ and ‘burn’ with a filter in the search for human studies. The relevant references in the articles obtained were also searched for and included in the review Results: Sixty-three journal articles were reviewed for contents in line with the objectives of this study. Conclusion: Glycerolised skin graft is a viable option for coverage of extensive burns in LMICs.

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“…En lugares donde la tasa de donación general y particular de piel es baja y en otros en donde su uso todavía no está legalizado principalmente por motivos culturales y religiosos, se abre como opción al uso de AC proveniente de donante vivo de pacientes sometidas a procedimientos de contorno corporal, en este caso particular a una abdominoplastía 20,21 . El número de donantes efectivos de piel en Chile en el trienio 2017-2019 fue de sólo cuatro donantes, obteniendo 3.051 cm 2 , 1.069 cm 2 y 6.839 cm 2 de piel por año respectivamente (todos donantes cadavéricos).…”

Section: Discussionunclassified

Procuramiento y uso de aloinjertos cutáneos de piel total criopreservados obtenidos de pacientes sometidas a abdominoplastía

Canteros¹,

Soto²,

Orlandini³

et al. 2022

Rev. Cirugia

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Introducción: Los aloinjeros cutáneos (AC) son excelentes sustitutos cutáneos temporales, sin embargo, la donación y procura de piel cadavérica, fuente habitual de AC, es baja. Objetivo: Evaluar la factibilidad de utilizar la piel proveniente de abdominoplastías como fuente de AC y su eficacia clínica. Materiales y Método: Entre el 17 de agosto de 2020 al 28 de febrero de 2021, se analizó una corte prospectiva de 14 pacientes femeninas sometidas a abdominoplastía por motivos estéticos, que aceptaron donar la piel del colgajo cutáneo abdominal redundante, la cual fue criopreservada. Se utilizaron los AC de piel total (ACPT) en 10 pacientes con diagnósticos de: pie diabético (4), laparostomía contenida (2) herida compleja extremidad inferior (2), sarcoma de cuero cabelludo recidivado (1) y melanoma (1). Resultados: Se obtuvieron 14 colgajos de piel total, los cuales fueron procesados obteniendo una superficie promedio de 302 cm2 y 8,3 láminas de distintos tamaños de utilidad clínica por paciente. En todos los pacientes en que se utilizó ACPT hubo un prendimiento inicial del AC para posteriormente, en promedio 21 días, presentar una escara necrótica que al ser retirada presentaba un tejido vital adherido al receptor rico en fibroblastos, siendo algunos pacientes auto injertados y otros manejados con cicatrización por segunda intención como tratamiento definitivo. Discusión: Los ACPT proporcionan una cobertura intermedia, pues una parte se integra en forma definitiva, actuando como un andamiaje biológico para la formación de una interfase sobre la cual se puede autoinjertar o dejar evolucionar con cicatrización por segunda intención y una parte es rechazada. Conclusión: La procura de piel de donante vivo, en pacientes sometidos a cirugías de contorno corporal es un proceso factible, fuente de ACPT, los cuales permiten una nueva cobertura intermedia con múltiples aplicaciones clínicas.

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Banking and use of glycerol preserved full-thickness skin allograft harvested from body contouring procedures

Cited by 13 publications

References 29 publications

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Maximizing the safety of glycerol preserved human amniotic membrane as a biological dressing

Glycerolised Skin Allografts for Extensive Burns in Low- and Middle-income Countries

Procuramiento y uso de aloinjertos cutáneos de piel total criopreservados obtenidos de pacientes sometidas a abdominoplastía

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