Barriers to prenatal care and poor pregnancy outcomes among women with syphilis in the Russian Federation

Southwick, K; Tikhonova, Lilia; Salakhov, Edward; Shakarishvili, A; Ryan, Caroline; Hillis, Susan D.

doi:10.1258/095646207781024748

Cited by 6 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…0.34 – 5.75[24]: RR 1.4; 95% c.i. 1.05 – 1.86 [32]) while two studies found no elevated stillbirth risk (RR 0.94: 95% c.i. 0.90 – 0.98 [27]: RR 0.68; 95% c.i.…”

Section: Resultsmentioning

confidence: 99%

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

et al. 2011

View full text Add to dashboard Cite

BackgroundGlobally syphilis is an important yet preventable cause of stillbirth, neonatal mortality and morbidity.ObjectivesThis review sought to estimate the effect of detection and treatment of active syphilis in pregnancy with at least 2.4MU benzathine penicillin (or equivalent) on syphilis-related stillbirths and neonatal mortality.MethodsWe conducted a systematic literature review of multiple databases to identify relevant studies. Data were abstracted into standardised tables and the quality of evidence was assessed using adapted GRADE criteria. Where appropriate, meta-analyses were undertaken.ResultsModerate quality evidence (3 studies) supports a reduction in the incidence of clinical congenital syphilis of 97% (95% c.i 93 – 98%) with detection and treatment of women with active syphilis in pregnancy with at least 2.4MU penicillin. The results of meta-analyses suggest that treatment with penicillin is associated with an 82% reduction in stillbirth (95% c.i. 67 – 90%) (8 studies), a 64% reduction in preterm delivery (95% c.i. 53 – 73%) (7 studies) and an 80% reduction in neonatal deaths (95% c.i. 68 – 87%) (5 studies). Although these effect estimates were large and remarkably consistent across studies, few of the studies adjusted for potential confounding factors and thus the overall quality of the evidence was considered low. However, given these large observed effects and a clear biological mechanism for effectiveness the GRADE recommendation is strong.ConclusionDetection and appropriate, timely penicillin treatment is a highly effective intervention to reduce adverse syphilis-related pregnancy outcomes. More research is required to identify the most cost-effective strategies for achieving maximum coverage of screening for all pregnant women, and access to treatment if required.

show abstract

“…0.34 – 5.75[24]: RR 1.4; 95% c.i. 1.05 – 1.86 [32]) while two studies found no elevated stillbirth risk (RR 0.94: 95% c.i. 0.90 – 0.98 [27]: RR 0.68; 95% c.i.…”

Section: Resultsmentioning

confidence: 99%

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Thirty‐eight articles were obtained from the database searches. Based on a preliminary review of the abstracts, 18 articles were excluded because they were not original economic analyses [17–34] . The remaining 20 articles were then located and the full articles were evaluated to determine if they met the study criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Based on a preliminary review of the abstracts, 18 articles were excluded because they were not original economic analyses. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] The remaining 20 articles were then located and the full articles were evaluated to determine if they met the study criteria. After reviewing the full articles, one article was excluded because it was not on Russia [35] and three were excluded because they were not original economic analyses.…”

Section: Resultsmentioning

confidence: 99%

The state of health economics and pharmaceoconomics research in Russia: a systematic review

Gavaza

Shepherd

Shcherbakova

et al. 2010

Journal of Pharmaceutical Health Services Research

View full text Add to dashboard Cite

Objectives To investigate the state of health economic research in Russia available in the English language by describing the number and characteristics of the articles, and assessing the quality of these articles. Methods The study assessed the state of health economics and pharmacoeconomics research in Russia. We conducted a literature search to identify health economics articles pertaining to Russia. Each article in the final sample was scored by two reviewers independently using the data‐collection form designed for the study. Key findings In total, 16 studies investigating a wide variety of diseases were included in the study. These articles were published in 15 different journals all based outside of Russia between 1994 and 2009. On average, each article was written by seven authors. Most first authors had medical/clinical training and resided in the USA (n = 8) at the time of publication of the study. Based on a scale of 1–10, with 10 indicating the highest quality, the mean quality score for all studies was 8.09 (SD = 1.29) and 25% of the articles were of fair quality (score 5–7). The quality of articles was statistically significantly related (P < 0.05) to the primary health intervention (pharmaceuticals > non‐pharmaceuticals) and primary training of the first author (medical > non‐medical). Conclusions The conduct of health economics and pharmacoeconomics research in Russia in the English language is limited and, on average, the published articles were of good quality. However, about one‐quarter of published articles were of fair quality. More health economics research in English is warranted in Russia.

show abstract

“…With this high sero-prevalence rate, there is a corresponding high potential for congenital syphilis [18, 24]. Lower genital tract infections have been shown to contribute to adverse pregnancy outcomes [25, 26]. These infections can ascend the reproductive tract and while in the amniotic fluid trigger a pro-inflammatory cytokine cascade that results in the initiation of labor and consequently preterm delivery [27].…”

Section: Discussionmentioning

confidence: 99%

Antenatal Care Attendance, a Surrogate for Pregnancy Outcome? The Case of Kumasi, Ghana

Asundep

Jolly

Carson

et al. 2013

Matern Child Health J

View full text Add to dashboard Cite

Objective Antenatal care (ANC) has been shown to influence infant and maternal outcomes. WHO recommends 4 ANC visits for uncomplicated pregnancies. However, pregnant women in Ghana are required to attend 8–13 antenatal visits. We investigated the association of ANC attendance with adverse pregnancy outcomes (defined as low infant birth weight, stillbirth, preterm delivery or small for gestational age). Method A quantitative cross-sectional study was conducted on 629 women, age 19–48 years who presented for delivery at two selected public hospitals and 16 traditional birth attendants from July-November 2011. Socio-demographic and antenatal information were collected using a structured questionnaire. ANC attendance, medical and obstetric/gynecological history were abstracted from maternal antenatal records. Data were analyzed using chi-square and logistic regression. Results Twenty-two percent of the women experienced an adverse outcome. Eleven percent of the women attended <4 ANC visits. In an unadjusted model, these women had an increased likelihood of experiencing an adverse outcome (OR = 2.27; 95 CI% = 1.30–3.94; p = 0.0038). High parity was also associated with adverse birth outcomes. Women screened for syphilis or use of insecticide-treated bed nets had a 40% and 36% (p = 0.0447 and p = 0.0293) reduced likelihood of experiencing an adverse pregnancy outcome respectively. After adjusting for confounders, attending <4 antenatal visits was associated with adverse pregnancy outcome compared with ≥4 ANC visits (Adjusted OR = 2.55; 95% CI = 1.16– 5.63; p = 0.0202). Conclusion Attending <4 antenatal visits and high parity were associated with adverse pregnancy outcomes for uncomplicated pregnancies.

show abstract

Barriers to prenatal care and poor pregnancy outcomes among women with syphilis in the Russian Federation

Cited by 6 publications

References 4 publications

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality

The state of health economics and pharmaceoconomics research in Russia: a systematic review

Antenatal Care Attendance, a Surrogate for Pregnancy Outcome? The Case of Kumasi, Ghana

Contact Info

Product

Resources

About