Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65–74 years

Lindholt, Jes Sanddal; Rasmussen, Lars Melholt; Søgaard, Rikke; Lambrechtsen, Jess; Steffensen, Flemming Hald; Frost, Lars; Egstrup, Kenneth; Urbonavičienė, Gražina; Busk, Martin; Olsen, Michael Hecht; Hallas, Jesper; Diederichsen, Axel Cosmus Pyndt

doi:10.1002/bjs.11135

Cited by 47 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients were invited as previously described in the Danish Cardiovascular Screening Trial (DANCAVAS). 14 In brief, patients received an electronic letter of invitation with information about the screening program. If interested, an appointment was booked online or by phone or e-mail.…”

Section: Invitation and Bookingmentioning

confidence: 99%

“…Aortic/iliac dilatations or aneurysms were defined as ascending aorta ≥50 mm, arcus aorta ≥45mm, descending aorta ≥35mm, abdominal aorta ≥30mm or a common iliac artery ≥20mm. 14…”

Section: Aneurysmsmentioning

confidence: 99%

“…Peripheral artery disease was defined as an ankle-brachial index of 0.9 or less, or at least 1.4. 14…”

Section: Peripheral Artery Diseasementioning

confidence: 99%

See 2 more Smart Citations

<p>Feasibility Study of Advanced Cardiovascular Screening in Middle-Aged Patients with Diabetes</p>

Lindholt¹,

Frystyk²,

Hallas³

et al. 2020

CLEP

Self Cite

View full text Add to dashboard Cite

Purpose: Cardiovascular mortality remains high among patients with diabetes compared with the general population. The primary aim was to evaluate the interest in and demand for advanced cardiovascular screening in patients with diabetes; the secondary aim was to explore its efficiency in detecting unprotected subclinical cardiovascular disease (CVD). Patients and Methods: In a cross-sectional design, randomly selected 40-60-year-old men and women with diabetes were invited to the screening trial. Screening encompassed (1) a comprehensive medical interview; (2) non-contrast computed tomography scanning to quantify coronary artery and aortic valve calcification, to measure left atrial size, to assess heart rhythm and to detect aortic and iliac dilatations; (3) ankle and brachial blood pressure measurements; and (4) blood and urine samples for measurements of HbA 1c , lipid profile, renal function, NT-pro B-type natriuretic peptide (pro-BNP) and albuminuria. Primary outcome was participation rate; secondary outcome was rate of unprotected subclinical CVD. Results: Of 465 invited patients, 191 (41.1%) attended screening. The participation rate was 40% (95% CI:33-47) for males and 42% (95% CI:36-48) for females. Twenty-four patients were excluded due to previous CVD. The remaining patients' mean age was 52 years; 58% were males. Subclinical CVD was found in 64%, with a male preponderance (males 75% (95% CI:66-83; females 49% (95% CI:37-60)). Presence of severe coronary artery calcification (score ≥ 400) showed a male preponderance (males 19% (95% CI:12-27); females 7% (95% CI:3-16)). Aortic valve calcification, enlarged left atrial volume, atrial fibrillation, aortic dilatations, peripheral artery disease or increased pro-BNP were uncommon, and without any sex differences. Unprotected subclinical CVD was very common, and medical treatment was intensified in 60% (95% CI:53-68) of patients. Conclusion: We propose a feasible cardiovascular screening examination from which middle-aged patients with diabetes may benefit. However, the participation rate may be too low to warrant screening.

show abstract

Section: Invitation and Bookingmentioning

confidence: 99%

“…Aortic/iliac dilatations or aneurysms were defined as ascending aorta ≥50 mm, arcus aorta ≥45mm, descending aorta ≥35mm, abdominal aorta ≥30mm or a common iliac artery ≥20mm. 14…”

Section: Aneurysmsmentioning

confidence: 99%

See 1 more Smart Citation

<p>Feasibility Study of Advanced Cardiovascular Screening in Middle-Aged Patients with Diabetes</p>

Lindholt¹,

Frystyk²,

Hallas³

et al. 2020

CLEP

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, 48% of people with T2D detected through screening did not attend their 12-year follow-up in the Anglo-Danish-Dutch study that explored whether screening for T2D and subsequent intensive treatment could reduce cardiovascular events (ADDITION-study) [4]. Conversely, the uptake was found to be higher in the general populations invited to attend screening for multiple CVD: it ranged from 62 to 74% [5][6][7] and up to 84% among men invited to attend screening for abdominal aortic aneurysm [8]. However, in a randomised trial offering screening for atrial fibrillation, the uptake was only 48.6% [9].…”

Section: Introductionmentioning

confidence: 99%

Facilitating participation in cardiovascular preventive initiatives among people with diabetes: a qualitative study

et al. 2021

View full text Add to dashboard Cite

Background Type 2 diabetes (T2D) is associated with a significantly increased risk of cardiovascular disease (CVD). The DIAbetic CArdioVAscular Screening and intervention trial (DIACAVAS) was designed to clarify whether advanced imaging for subclinical atherosclerosis combined with medical treatment is an effective strategy to develop individualised treatment algorithms for Danish men and women with T2D aged 40–60. But in the DIACAVAS pilot study, the uptake was only 41%. Consequently, we explored how people experienced living with T2D to understand how to improve the uptake in initiatives targeting the prevention of CVD. Methods We used semi-structured interviews to obtain information on how the respondents experienced having T2D. For supplementary information, we used structured interviews on e.g. socioeconomic factors. From April to October 2019, 17 participants aged 40–60 years were recruited from general practices and diabetes outpatient clinics in Denmark. Several levels of analysis were involved consistent with inductive content analysis. Results The participants’ experiences of living with T2D fell along two continuums, from an emotional to a cognitive expression and from reactive to proactive disease management. This led to identification of four archetypal characteristics: (I) powerlessness, (II) empowerment, (III) health literacy, and (IV) self-efficacy. These characteristics indicated the importance of using different approaches to facilitate participation in cardiovascular preventive initiatives. Additionally, findings inspired us to develop a model for facilitating participation in future preventive initiatives. Conclusion Encouraging people with T2D to participate in cardiovascular preventive initiatives may necessitate a tailored invitation strategy. We propose a model for an invitational process that takes into consideration invitees’ characteristics, including powerlessness, empowerment, health literacy and self-efficacy. This model may enhance participation in such initiatives. However, participation is a general concern, not only in relation to cardiovascular prevention. Our proposed model may be applicable in preventive services for people with T2D in general.

show abstract

Section: Introductionmentioning

confidence: 99%

Facilitating participation in cardiovascular preventive initiatives among people with diabetes: a qualitative study

Dahl

Søndergaard

Diederichsen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Type 2 diabetes (T2D) is associated with a significantly increased risk of cardiovascular disease (CVD). The DIAabetic CArdioVAscular Screening and intervention trial (DIACAVAS) was designed to clarify whether advanced imaging for subclinical atherosclerosis combined with medical treatment is an effective strategy to develop individualised treatment algorithms for Danish men and women with T2D aged 40–60. But in the DIACAVAS pilot study, the uptake was only 41%. Consequently, we explored how people experienced living with T2D to understand how to improve the uptake in initiatives targeting the prevention of CVD. Methods: We used semi-structured interviews to obtain information on how the respondents experienced having T2D. For supplementary information, we used structured interviews on e.g. socioeconomic factors. From April to October 2019, 17 participants aged 40–60 years were recruited from general practices and diabetes outpatient clinics in Denmark. Several levels of analysis were involved consistent with inductive content analysis.Results: The participants’ experiences of living with T2D fell along two continuums, from an emotional to a cognitive expression and from proactive to reactive disease management. This led to identification of four archetypal characteristics: (I) powerlessness, (II) empowerment, (III) health literacy, and (IV) self-efficacy. These characteristics indicated the importance of using different approaches to facilitate participation in cardiovascular preventive initiatives. Additionally, findings inspired us to develop a model for facilitating participation in future preventive initiatives.Conclusion: Encouraging people with T2D to participate in cardiovascular preventive initiatives may necessitate a tailored invitation strategy. We propose a model for an invitational process that takes into consideration invitees’ characteristics, including powerlessness, empowerment, health literacy and self-efficacy. This model may enhance participation in such initiatives. However, participation is a general concern, not only in relation to cardiovascular prevention. Our proposed model may be applicable in preventive services for people with T2D in general.

show abstract

Baseline findings of the population-based, randomized, multifaceted Danish cardiovascular screening trial (DANCAVAS) of men aged 65–74 years

Cited by 47 publications

References 37 publications

<p>Feasibility Study of Advanced Cardiovascular Screening in Middle-Aged Patients with Diabetes</p>

<p>Feasibility Study of Advanced Cardiovascular Screening in Middle-Aged Patients with Diabetes</p>

Facilitating participation in cardiovascular preventive initiatives among people with diabetes: a qualitative study

Facilitating participation in cardiovascular preventive initiatives among people with diabetes: a qualitative study

Contact Info

Product

Resources

About