BAY 41-2272 inhibits human T lymphocyte functions

CD138 promotes the accumulation and activation of autoreactive T cells in autoimmune MRL/lpr mice

“…PI stimulation could also significantly decrease CD138 protein expression in CD138 + T cells. PI stimulation has been used to activate T cells and promote cytokines secretion in T cells (22,23). However, in the present study, PI stimulation was able to prevent CD138 + T cell accumulation by inducing specific apoptosis of CD138 + T cells.…”

“…In addition, it was demonstrated that CD69 + cells in the CD138 + T cell population had a significant increase in apoptosis levels compared to CD69cells in the CD138 + T cell population. However, both PI stimulation and TCR activation could significantly activate T cells and subsequently increase the number of CD69 + cells in the T cell population (22,39). The present study demonstrated that the increased apoptosis of CD138 + T cells and subsequent decreased accumulation of CD138 + T cells were a result of the activation of CD138 + T cells via the increase of CD69 protein expression.…”

“…receptor (TCR) activation negatively regulates CD138 protein expression in DN T cells (14). PMA and PI are commonly used to activate T cells and promote cytokine secretion in T cells (22,23). In the present study, the effect of PI stimulation on CD138 + T cell accumulation in splenocytes of MRL/lpr mice was assessed.…”

Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model

“…The activation of the NO/cGMP pathway can promote cell proliferation [ 63 ]. Carvalho et al [ 64 ] showed that decreased cGMP and NO levels in T LYM decreased the cytokines mRNA levels, such as IFN-γ and IL-2. In this study, CBH and HD regulated the proliferation of splenic LYM via the NO/cGMP signaling pathway and regulated cytokine gene transcription, affecting cytokine secretion and fulfilling an immunomodulatory function.…”