Beam Dynamics for ARIA

Ekdahl, C.A.

doi:10.2172/1158826

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Previous LSP-Slice PIC simulations of round beams in the solenoidal fields of the DARHT LIAs have agreed with simulations by the envelope code XTR [4] [6] [12]. The version of XTR used for these comparisons has exactly the same physics models and approximations for round beams as the LAMDA envelope code, which can also simulate elliptical beams transported by quadrupole magnets.…”

Section: A Comparison With Envelope Codesmentioning

confidence: 71%

Emittance growth in the DARHT Axis-II Downstream Transport

Ekdahl

Schulze

2015

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Using a particle-in-cell (PIC) code, we investigated the possibilities for emittance growth through the quadrupole magnets of the system used to transport the high-current electron beam from an induction accelerator to the bremsstrahlung converter target used for flash radiography. We found that even highly mismatched beams exhibited little emittance growth (< 6%), which we attribute to softening of their initial hard edge current distributions. We also used this PIC code to evaluate the accuracy of emittance measurements using a solenoid focal scan following the quadrupole magnets. If the beam is round after the solenoids, the simulations indicate that the measurement is highly accurate, but it is substantially inaccurate for elliptical beams.

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Section: A Comparison With Envelope Codesmentioning

confidence: 71%

Emittance growth in the DARHT Axis-II Downstream Transport

Ekdahl

Schulze

2015

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“…This result is also consistent with previous findings that anti-cancer drugs may facilitate a process of neuroinflammation, microglial activation and suppression of neurogenesis in adults. [37][38][39][40][41][42] For cluster 2 ( Figure 4B), in which proteins mainly showed increased levels, one prominent biological process is neuron projection and regeneration which means regrowth of neuronal processes (axons or dendrites) in response to their loss or damage. 75 The increased activity of proteins regulating neuronal regeneration may represent the response of brain or spinal cord injury due to chemotherapy treatment.…”

Section: Gene Ontology Analysismentioning

confidence: 99%

“…17, [34][35][36] Systemic inflammation with cytokine release, which may occur in cancer patients as a response to mucositis and systemic infections, may facilitate a process of neuroinflammation, microglial activation and suppression of neurogenesis. [37][38][39][40][41][42] For clinical practice it would be ideal to have biomarkers indicative of the toxicity severity of chemotherapy on the CNS. This would help identify vulnerable patients during early treatment, when there is still time to intervene.…”

Section: Introductionmentioning

confidence: 99%

Isobaric Labeling Strategy Utilizing 4-Plex N,N-Dimethyl Leucine (DiLeu) Tags Reveals Proteomic Changes Induced by Chemotherapy in Cerebrospinal Fluid of Children with B-Cell Acute Lymphoblastic Leukemia

Zhong

Chen

et al. 2020

J. Proteome Res.

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The use of mass spectrometry for protein identification and quantification in cerebrospinal fluid (CSF) is at the forefront of research efforts to identify and explore biomarkers for the early diagnosis and prognosis of neurologic disorders. Here, we implemented 4-plex N,N-dimethyl leucine (DiLeu) isobaric labeling strategy in a longitudinal study aiming to investigate protein dynamics in children with B-cell acute lymphoblastic leukemia (B-cell ALL) undergoing chemotherapy. The temporal profile of CSF proteome during chemotherapy treatment at weeks 5, 10-14 and 24-28 highlighted many differentially expressed proteins, such as neural cell adhesion molecule, neuronal growth regulator 1, and secretogranin-3, all of which play important roles in neurodegenerative diseases. A total of 63 proteins were significantly altered across all the time *

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Characterization and modeling of amorphous metallic cores

Taccetti¹,

Johnson²,

Rose³

2015

2015 IEEE Pulsed Power Conference (PPC)

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Los Alamos is planning a new compact multi-pulsed electron linear induction accelerator (LIA) for flash radiography of explosively driven hydrodynamic experiments, the Advanced Radiography Induction Accelerator (ARIA). In order to operate in multi-pulse mode without the need to reset the inductor cores between each pulse, the design incorporates amorphous metallic glass cores. Due to their high magnetic saturation value, these provide enough volt-seconds for sequential pulsing before reaching saturation. Although metallic glass cores are used extensively, their behavior depends greatly on the particular formulation and on the specific application. For this reason, we have undertaken an effort to better characterize the cores under consideration and use this data to develop models that can be used in EM simulations. We present the characterization of two types of cores being considered: Metglas 2605CO and 2605HB1M cores. We include detailed measurements of BH curves at various magnetization rates, measurements of multiple pulses on the same core, and initial modeling efforts.

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Beam Dynamics for ARIA

Cited by 6 publications

References 26 publications

Emittance growth in the DARHT Axis-II Downstream Transport

Emittance growth in the DARHT Axis-II Downstream Transport

Isobaric Labeling Strategy Utilizing 4-Plex N,N-Dimethyl Leucine (DiLeu) Tags Reveals Proteomic Changes Induced by Chemotherapy in Cerebrospinal Fluid of Children with B-Cell Acute Lymphoblastic Leukemia

Characterization and modeling of amorphous metallic cores

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