Behavior of human neural progenitor cells transplanted to rat brain

Александрова, М. А.; Сабурина, И.Н.; Полтавцева, Р. А.; Revishchin, A. V.; Korochkin, L. I.; Сухих, Г. Т.

doi:10.1016/s0165-3806(02)00273-0

Cited by 29 publications

(18 citation statements)

References 38 publications

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“…Precultured stem/progenitor cells from human fetal brain were transplanted into intact or damaged brain (hypoxic hypoxia), or into mechanically damaged spinal cord of adult rats [1][2][3][4][5]7].…”

Section: Methodsmentioning

confidence: 99%

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Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

et al. 2005

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The fate of human fetal stem/progenitor cells transplanted into rat brain depends on conditions of preculturing (long or short) and state and site of transplantation. Human nestin-positive stem cells cultured according to the short protocol did not migrate into hypoxic and normal brain after transplantation, but actively migrated in damaged spinal cord. After transplantation of long-cultured cells into the brain mainly committed neuroblasts and solitary nestin-positive cells migrated from the site of transplantation into the brain.

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Section: Methodsmentioning

confidence: 99%

“…We studied the effect of the status of recipient brain and the regimen of culturing of the transplanted material on the behavior of human fetal cells transplanted into rat brain [1][2][3][4][5]7,12].…”

mentioning

confidence: 99%

Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

et al. 2005

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“…Another question would be to examine the specific methods by which the transplanted cells migrate to the target area. Aleksandrova et al described the ability of NSCs to extensively and site-specifically migrate [16]. Furthermore, there are reports that NSCs injected into the ventricle were extensively transported by cerebrospinal fluid (CSF), survived, and notably, migrated into neural tissues [17 -19].…”

Section: Considerations For Neuroreplacement Therapiesmentioning

confidence: 99%

Neuroreplacement therapy and stem cell biology under disease conditions

Sugaya

2003

Cellular and Molecular Life Sciences (CMLS)

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Recent advances in stem cell technology are expanding our ability to replace a variety of cells throughout the body. In the past, neurological diseases caused by the degeneration of neuronal cells were considered incurable because of a long-held 'truism'; neurons do not regenerate during adulthood. However, this statement has been challenged, and we have now found much evidence that the brain is indeed capable of regenerating neurons after maturing. Based on this new concept, researchers have shown neural differentiation of stem cells and recovery of function following transplantation of these cells into the brain. These results may promise a bright future for clinical applications of stem cell strategies in neurological diseases; however, we must consider the pathophysiological environments of individual diseases that may affect stem cell biology. Before we begin to develop clinical applications, we must consider environmental factors that have not been discussed in the current preclinical studies. Here, we study cases of Alzheimer's disease and schizophrenia and discuss the effects of environmental factors under disease conditions.

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“…If these cells have the ability to choose between differentiation or quiescence, once could propose that NSCs appear to be able to autoregulate their population, in order to maintain self-renewal instead of becoming depleted following the generation of neuronal and glial progenitors. Three other studies have also contributed new data on the performance of human forebrain neural precursors from neurosphere strains grown with EGF/FGF2/LIF and grafted into the neonatal or adult rat brain (Englund et al, 2002a, b;Aleksandrova et al,. 2002).…”

Section: In Vivo Performance Of Human Neural Stem/ Precusor Cells Aftmentioning

confidence: 99%

“…It can also be interpreted as a hurdle, since many of the grafted cells are unable to differentiate when implanted into non-germinal zones. Aleksandrova et al (2002) also describe the performance of implants of neurosphere cells into the young/adult rat brain. The cells were derived from 8-12 week old fetuses and were expanded in culture for 14 days prior to use, and the host brains were examined 10-20 days post-transplantation.…”

Section: In Vivo Performance Of Human Neural Stem/ Precusor Cells Aftmentioning

confidence: 99%

Isolation, Survival, Proliferation, and Differentiation of Human Neural Stem Cells

Navarro¹,

Villa²,

Liste³

et al.

Neural Stem Cells

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Behavior of human neural progenitor cells transplanted to rat brain

Cited by 29 publications

References 38 publications

Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

Human Fetal Neural Stem Cells in Rat Brain: Effects of Preculturing and Transplantation

Neuroreplacement therapy and stem cell biology under disease conditions

Isolation, Survival, Proliferation, and Differentiation of Human Neural Stem Cells

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