Behavior of seeds and soil in the mechanism of metastasis: A deeper understanding

Mathot, Lucy; Stenninger, Johan

doi:10.1111/j.1349-7006.2011.02195.x

Cited by 81 publications

(60 citation statements)

References 56 publications

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“…Since Stephen Paget proposed the famous 'seed and soil' hypothesis, the tumor microenvironment has been a focus in cancer research [117]. It is now well recognized that the tumor microenvironment is involved in every stage of cancer, including tumorigenesis, cancer proliferation, metastasis and drug resistance [69].…”

Section: Nfats In the Tumor Microenvironmentmentioning

confidence: 99%

Nuclear factor of activated T cells in cancer development and treatment

et al. 2015

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Since nuclear factor of activated T cells (NFAT) was first identified as a transcription factor in T cells, various NFAT isoforms have been discovered and investigated. Accumulating studies have suggested that NFATs are involved in many aspects of cancer, including carcinogenesis, cancer cell proliferation, metastasis, drug resistance and tumor microenvironment. Different NFAT isoforms have distinct functions in different cancers. The exact function of NFAT in cancer or the tumor microenvironment is context dependent. In this review, we summarize our current knowledge of NFAT regulation and function in cancer development and treatment. NFATs have emerged as a potential target for cancer prevention and therapy.

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Section: Nfats In the Tumor Microenvironmentmentioning

confidence: 99%

Nuclear factor of activated T cells in cancer development and treatment

et al. 2015

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“…The tumor microenvironment also plays an important role in metastasis [9,10]. However, understanding all the underlying complexities of tumor metastasis for developing successful cancer diagnosis and prevention tools is a difficult challenge.…”

Section: Introductionmentioning

confidence: 99%

Anterior gradient 2: A novel sensitive tumor marker for metastatic oral cancer

Chen¹,

Ho²,

Chen³

et al. 2013

Cancer Letters

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“…Although there are many theories for tumor metastasis, such as seed and soil hypothesis [16][17][18], and epithelial-to-mesenchymal transition (EMT) [19,20], full details of the underlying mechanism remain to be elucidated. At present, miRNAs research provides a new direction for tumor metastasis.…”

Section: Discussionmentioning

confidence: 99%