Behavioral Disorders in Alzheimer Disease: A Transcultural Perspective

Binetti, Giuliano; Mega, Michael S.; Magni, Eugenio; Padovani, Alessandro; Rozzini, Luca; Bianchetti, Angelo; Trabucchi, Marco; Cummings, Jeffrey L.

doi:10.1001/archneur.55.4.539

Cited by 103 publications

(93 citation statements)

References 18 publications

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“…A study of an instrument aimed to measure behaviour in AD patients has proved the transnational validity of this instrument, and has shown a similar behavioural pattern between the two different linguistic groups (Italian and USA) examined [4,49]. In conclusion, the clinical features of Alzheimer's disease do not change across different ethnical and cultural settings, suggesting that it is a disease biologically determined and not influenced by cultural or linguistic environment.…”

Section: Discussionmentioning

confidence: 91%

Validity of Different Linguistic Versions of the Alzheimer’s Disease Assessment Scale in an International Multicentre Alzheimer’s Disease Trial

Inzitari

Rossi

Lamassa

et al. 1999

Dement Geriatr Cogn Disord

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Owing to the involvement of Italian Centres in a multicentre, German-Italian therapeutical trial with Alzheimer’s dementia patients, to be assessed with the Alzheimer’s Disease Assessment Scale (ADAS), it was decided that the Italian centres would use an Italian version of the scale, derived from that used by the German centres. However, the lists of words for exploring verbal memory are not merely translated from the German version, but are composed of selective Italian words chosen according to linguistic criteria. This Italian version was validated following the same procedure adopted for validating the German version. We submitted this Italian version to an interrater reliability, test-retest reliability, concurrent validity, internal consistency and sensitivity evaluation, using demented patients. Based on the results of these tests this Italian version of the ADAS proved valid and reliable. Moreover, the results were strikingly comparable to those from the validation of the German version. Our work supports the validity, reliability and transnational comparability of national versions of the ADAS constructed following definite linguistic criteria.

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Section: Discussionmentioning

confidence: 91%

Validity of Different Linguistic Versions of the Alzheimer’s Disease Assessment Scale in an International Multicentre Alzheimer’s Disease Trial

Inzitari

Rossi

Lamassa

et al. 1999

Dement Geriatr Cogn Disord

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“…Nevertheless, whereas most of the previous studies were conducted on less homogeneous clinical samples including subjects with possible and probable AD [25,43] or even different forms of dementia [8,15,17], we have assessed a group of subjects with probable AD, thus providing a higher biological validity. The behavioral assessment scale we used (NPI) could be considered quite rough for the evaluation of fine behavioral changes; nevertheless, it is broadly used and well-validated in Italian [33] and could provide information about a wide range of neuropsychiatric symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Each subject underwent the 12-item version of the Neuropsychiatric Inventory (NPI) [33,34], a caregiver-based clinical interview exploring 12 behavioral domains (delusions, HALL, agitation/aggression, depression, anxiety, euphoria, apathy, disinhibition, irritability, abnormal motor behavior, sleep, and appetite disturbances).…”

Section: Methodsmentioning

confidence: 99%

Cognitive and Behavioral Determinants of Psychotic Symptoms in Alzheimer's Disease

Quaranta¹,

Vita²,

Bizzarro³

et al. 2015

Dement Geriatr Cogn Disord

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Aims: To investigate the relationship between psychotic symptoms and cognitive impairment in Alzheimer's disease (AD). Methods: A total of 108 subjects affected by AD were subdivided into subjects without delusions (ND), subjects with paranoid delusions (PD), subjects with delusional misidentifications (DM), subjects with both DM and PD (DM+PD), subjects with visual hallucinations (v-HALL), and subjects without visual hallucinations (N-HALL). Results: PD and ND subjects performed similarly on neuropsychological tests, while DM patients performed significantly worse than PD and ND patients. v-HALL patients performed worse than N-HALL patients on memory, visuospatial, and executive functions. As for behavioral features, DM and v-HALL subjects reported higher scores on the abnormal motor behavior subscale of the neuropsychiatric inventory (NPI); PD subjects reported higher scores on the disinhibition subscale of the NPI. The severity of PD was predicted by the severity of disinhibition (B = 0.514; p = 0.016) but not by neuropsychological performances. The severity of DM was predicted by age (B = 0.099; p = 0.048) and MMSE (B = -0.233; p = 0.001). The severity of v-HALL was predicted by age (B = 0.052; p = 0.037) and scores on an immediate visual memory task (B = -0.135; p = 0.007). Conclusions: The occurrence of PD may require the relative sparing of cognitive functions and be favored by frontal lobe dysfunction, while DM is associated with the overall level of cognitive impairment. Finally, v-HALL are associated with the impairment of visuospatial abilities.

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“…The manifestations of BPSD symptoms can vary to some degree according the patients's ethnic, cultural and social background (24)(25). Apathy and depression is reported more in western cultures (24)(25) in contrast to more activity disturbance and aggressiveness reported in patients from non-western backgrounds.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of behavioral and psychological symptoms in patients with vascular and Alzheimer dementia

Javed¹,

Gaur²,

Ibrahim³

et al. 2017

Sri Lanka J. Psyc.

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BackgroundDementia is a common, disabling disorder of the elderly. With the steady growth in the older population, the rate of dementia is expected to increase two fold by 2030 and three fold by 2050. Dementia of Alzheimer Type (DAT) and vascular dementia (VD) are among the most common types of dementia. Behavioral and psychological symptoms of dementia (BPSD) are associated with increased patient morbidity and carer burden.

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Behavioral Disorders in Alzheimer Disease: A Transcultural Perspective

Cited by 103 publications

References 18 publications

Validity of Different Linguistic Versions of the Alzheimer’s Disease Assessment Scale in an International Multicentre Alzheimer’s Disease Trial

Validity of Different Linguistic Versions of the Alzheimer’s Disease Assessment Scale in an International Multicentre Alzheimer’s Disease Trial

Cognitive and Behavioral Determinants of Psychotic Symptoms in Alzheimer's Disease

A comparative study of behavioral and psychological symptoms in patients with vascular and Alzheimer dementia

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