Behavioural and psychological syndromes in Alzheimer's disease

Abstract

We report novel observations that agitation/aggression/irritability cluster within a depressive symptom factor and apathy is found within a physical behaviour factor.

Point and 5‐year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study

“…Similar to our findings of point prevalence, cumulative prevalence was greatest for depression (77%) and apathy (71%). In most prior studies using the NPI, apathy has been the most common symptom (Lyketsos et al, 2000;Mirakhur et al, 2004;Aalten et al, 2005).…”

Neuropsychiatric symptoms and associated caregiver stress in geriatric patients with Parkinson’s disease

“…The frequency and severity of psychiatric symptoms in the PDD group were even higher than those reported in clinical trials for PDD (17,18) and the distribution of psychiatric symptoms differed markedly between PDD patients and patients with moderate to severe AD (19), including our own cohort (20). Hallucinations were more severe in PD patients, while aberrant motor behaviour, agitation, disinhibition, irritability and euphoria were more severe in AD.…”

Clinical Characteristics of Behavioral and Psychological Symptoms in Patients with Drug-naïve Alzheimer's Disease

“…Previous studies have mainly focused on reducing NPI domain factors and thus defining sub-syndromes of AD [5][6][7][8][9][10]. However, our study focused on extracting homogenous groups from numerous NPI domains.…”

“…There has not been enough evidence allowing for individualization of each domain. In recent years, several studies have been attempted to identify the grouping of these symptom domains [5][6][7][8][9][10]. The potential advantages of this approach are that these groups might be more homogenous, thus allow a coherent explanation of the pathogenesis, prognosis and treatment [11].…”