Behavioural consequences of nucleus accumbens dopaminergic stimulation and glutamatergic blocking in pigeons

Acerbo, Martín J.; Gargiulo, Pascual Ángel; Krug, Ines; Delius, Juan D.

doi:10.1016/s0166-4328(02)00109-2

Cited by 21 publications

(29 citation statements)

References 26 publications

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“…Lesions of the ventral striatum elicit impulsive choice behavior based on the anticipated spatial proximity of reward (Aoki et al 2006). In another experiment, the apomorphine-induced pecking response of pigeons has been found to be more intense when the agent is injected into the peripheral, rather than the central, region of the Ac (Acerbo et al 2002), although these subdivisions are not based on histological markers and may not be fully equivalent to the AcS and AcC, as defined in the present study.…”

Section: Discussioncontrasting

confidence: 45%

Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)

Bálint

Csillag

2006

Cell Tissue Res

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The nucleus accumbens was identified in avian species some time ago. However, the precise localization and extent of this nucleus is still a matter of controversy. We have used immunolabeling against calbindin, neuropeptide Y, and DARPP-32 (dopamine- and adenosine-related phosphoprotein, 32 kDa) for the selective marking of putative accumbens subdivisions and have followed the anterograde transport of biotinylated dextran amine injected to the nucleus tractus solitarii region of 7-day-old domestic chicks. The nucleus accumbens extending between rostrocaudal atlas coordinates A 10.6 and A 8.8 can be subdivided into the core and shell, the core corresponding to the ventromedial and juxtaventricular medial striatum laterodorsal to the bed nucleus of stria terminalis, and the shell representing an arched region situated ventrally and ventrolaterally to the core. Immunoreactivity to both calbindin and neuropeptide Y is more intense in the shell than in the core division. DARPP-32 immunolabeling does not differ in the two divisions but is markedly weaker in the bed nucleus of stria terminalis, enabling the separation of this nucleus from the surrounding accumbens subdivisions. Fibers from the nucleus solitarius predominantly terminate in the shell division, similar to the situation described in mammals. Whereas the suggested core lies entirely within the boundary of the medial striatum, the shell seems partially to overlap the ventral pallidum. We have been unable to subdivide the remaining part of accumbens lying rostral to A 10.6 into a putative shell and core by the methods employed in the present study. This region probably corresponds to the rostral pole of the nucleus accumbens.

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Section: Discussioncontrasting

confidence: 45%

Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)

Bálint

Csillag

2006

Cell Tissue Res

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“…in animals, suggesting that a glutamatergic dysfunction within NAS is related to positive [2,21,[23][24][25]45] and negative [23,24,44] symptoms, and also, to working memory schizophrenic dysfunction [4]. These later findings are in accordance with the fact that NAS is considered today a switchboard for goaldirected behaviors [32].…”

supporting

confidence: 61%

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

López

Caif

Fraile

et al. 2013

Pharmacological Reports

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Abstract:Background: The effect of the agonism on g-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the nucleus accumbens septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect. Methods: Three rat groups received either saline or dipotassium chlorazepate (1 or 2 µg/1 µl solution) 15 min before testing. Time spent in the open arms (TSOA), time per entry (TPE), extreme arrivals (EA), open and closed arms entries (OAE, CAE) and relationship between open-and closed-arms quotient (OCAQ) were recorded. Results: In the AMY injected group TSOA, OAE and EA were increased by the higher doses of dipotassium chlorazepate (p < 0.01). In the mPFC, TPE was decreased by both doses (p < 0.05). Injection within ventral hippocampus (VH) decreased TSOA, OAE and OCAQ with lower doses (p < 0.05). When the three studied saline groups were compared, TSOA, OAE, EA and OCAQ were enhanced in the VH group when compared to mPFC and AMY (p < 0.001). Insertion of inner canula (p < 0.001, p < 0.01, p < 0.01) and saline injection showed an increasing significant difference (p < 0.001 in all cases) with the action of guide cannula alone within VH in TSOA, OAE and EA. Conclusion: We conclude that the injection of dipotassium chlorazepate has a differential effect depending of the brain area, leading to facilitatory and inhibitory effects on anxiety processing.

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“…Visual discrimination performance in the pigeon is impaired by injection of NMDA (N-methyl-D-aspartate)-glutamate receptor blockers, 5-or 7-aminophosphonoheptanoic acid, into BSTL (Gargiulo et al, 1998;Acerbo et al, 2002). The study suggests that BSTL plays a role in visual learning linked to glutamatergic input.…”

Section: Functional Implications Of the Avian Poac And Bstlmentioning

confidence: 91%

Fiber connections of the compact division of the posterior pallial amygdala and lateral part of the bed nucleus of the stria terminalis in the pigeon (Columba livia)

Atoji

Saito

Wild

2006

J of Comparative Neurology

140

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The compact division of the posterior pallial amygdala (PoAc) and lateral part of the bed nucleus of the stria terminalis (BSTL) are components of the limbic system in the pigeon brain. In this study, we examined the position and fiber connections of these two nuclei by using Nissl staining and tract-tracing methods. PoAc occupies a central division in the posterior pallial amygdala. BSTL faces the ventral horn of the lateral ventricle and extends between A 7.25 and A 10.50. PoAc and BSTL connect bidirectionally by the stria terminalis. PoAc connects reciprocally with two nuclear groups in the cerebrum: 1) a continuum consisting of the caudoventral nidopallium, lateral part of the caudoventral nidopallium (NCVl), subnidopallium beneath NCVl, and piriform cortex and 2) rostral areas of the hemisphere, including the frontolateral and frontomedial nidopallium and the densocellular part of the hyperpallium. Extratelencephalic projections of PoAc terminate in the dorsomedial thalamic nuclei and reach the lateral hypothalamic area via the hypothalamic part of the occipito-mesencephalic tract. BSTL also connects reciprocally with two main regions: 1) the same continuum as for PoAc projections, except the piriform cortex and 2) rostral areas of the hemisphere, including the olfactory tubercle and nucleus accumbens. Extratelencephalic reciprocal connections are with the substantia nigra, nucleus subceruleus dorsalis, parabrachial nucleus, locus coeruleus, and nucleus of the solitary tract. The dorsomedial subdivision of the hippocampal formation projects massively to PoAc and BSTL. These findings indicate that PoAc and BSTL are important components of an interconnected neural circuit involving widespread regions of the neuraxis and mediating limbic-visceral functions.

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Behavioural consequences of nucleus accumbens dopaminergic stimulation and glutamatergic blocking in pigeons

Cited by 21 publications

References 26 publications

Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)

Nucleus accumbens subregions: hodological and immunohistochemical study in the domestic chick (Gallus domesticus)

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

Fiber connections of the compact division of the posterior pallial amygdala and lateral part of the bed nucleus of the stria terminalis in the pigeon (Columba livia)

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