Beiträge zur Histogenese und Histologie der Netzhaut, des Pigmentepithels und des Sehnerven

Seefelder, R.

doi:10.1007/bf01943852

Cited by 38 publications

(6 citation statements)

References 31 publications

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“…Following the histogenesis of the retina in the cat (9), human being (10,11), and in the chicken embryo (12), a filament originating from a centrosome has been observed as the first indication of the external segment. According to Leplat (12) this filament became surrounded by a sheath of mitochondrial nature to constitute the external segment.…”

Section: The Primitive Cilium and The Outer Rod Segmentmentioning

confidence: 99%

Morphogenesis of the Retinal Rods

Robertis

1956

The Journal of Cell Biology

144

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PLATES 70 TO 73In a previous paper the submicroscopic morphology of the outer and inner segments of the rod cell of the adult retina has been described (1). The conclusion was drawn, that the fibrous connection between both segments is constituted by a short cilium, the so called "connecting cilium," which is composed of nine pairs of filaments, a basal body, matrix material, and a surface membrane. The outer or receptor segment of the rod, confirming the previous work of Sj6strand (2), is composed of a pile of numerous flattened sacs or cisternae bound by a thin membrane and constituting close compartments which are probably connected by short tubular stalks to the cilium. The inner segment contains the mitochondria in the distal part (ellipsoid) and, in the proximal part, leading to the rod fiber, the Golgi substance, endoplasmic reticulum, dense particles, and neuroprotofibrils. Both segments of the rod and the connecting cilium are limited by a continuous surface membrane. It was suggested that this membrane may be the site for the propagation of the nerve impulse originated at the level of the rod sacs by the photochemical reaction. It was also postulated that the entire outer segment of the rod may be organized as a differentiation of a primitive cilium (1).These observations and interpretations of the submicroscopic morphology of the adult rod cell made it highly interesting to study, with the electron microscope, the morphogenesis and differentiation of the inner and outer segments. For this purpose the retina of young mice was selected since at birth it is completely undifferentiated and the differentiation of the visual cells starts only after the 3rd or 4th day proceeding to completion between the 12th to the 16th day (3,4).In this material the development of a typical cilium and the differentiation of its apical portion to constitute the outer segment have been demonstrated. The basal portion of the primitive cilium with its basal body remains undifferentiated and constitutes the connecting cilium of the adult rod.This study throws also some light on the macromolecular mechanisms leading to the formation of the complex lamellar structure which constitutes the receptor portion of the rod cell. 209

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Section: The Primitive Cilium and The Outer Rod Segmentmentioning

confidence: 99%

Morphogenesis of the Retinal Rods

Robertis

1956

The Journal of Cell Biology

144

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“…Fürst on the salmon, Leboucq (1909) on six species of mammals, Magitot (1910), Seefelder (1910) and Mawas (1910) all independently on the human being and Leplat (1913) on the chick all describe the cytogeny of the visual cell in essentially identical terms. The early embryonic coating of fine stereocilia, which in some forms is present over the sclerad surface of the inner layer of the optic cup, is apparently soon lost,21 and each epithelioid young visual cell, when it commences to differentiate, is nude and contains a double centrosome lying toward the cleft between the retina proper and the future pigment epithelium.…”

Section: Visual Cellmentioning

confidence: 99%

“…stage in the human embryo (Mann, 1928), and it is not until the 34 mm. stage that the centrosomic filaments which are the visual cell outer segment anlages appear (Seefelder, 1910). depositing in a spiral organization which is retained by their descendant material into the adult condition (Franz, 1934 ft).…”

Section: Visual Cellmentioning

confidence: 99%

Origin of the Vertebrate Eye

Walls¹

1939

Archives of Ophthalmology

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“…Diese sind: 1. das primitive Epithelstadium, 2. die Randschleierbildung, 3. die Faserentwicklung. Bemerkenswert ist, dass die Bildung des l~ndsehleiers ganz unabh~ngig yon der Faserbildung erfolgt, worauf in der neuesten Zeit R. Seefelder (20,1919 Die in der vorliegenden Arbeit verSffentliehten Befunde bilden nur einen Teil yon Beobaehtu~gen, die ich im Verlaufe yon mehreren Jahren an meinem reiehhaltigen embryologisehen Material angestellt habe. Es handelt sieh um das Vorkommen yon physiologiseher Degeneration w~hrend der normalen Entwicklung und um die Deutung dieser Befunde.…”

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Über die einleitenden Vorgänge bei der ersten Entstehung der Nervenfasern im Nervus opticus

Szily¹

1912

Graefes Arhiv für Ophthalmologie

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Beiträge zur Histogenese und Histologie der Netzhaut, des Pigmentepithels und des Sehnerven

Cited by 38 publications

References 31 publications

Morphogenesis of the Retinal Rods

Morphogenesis of the Retinal Rods

Origin of the Vertebrate Eye

Über die einleitenden Vorgänge bei der ersten Entstehung der Nervenfasern im Nervus opticus

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