Beneficial Effect of a Collagen Peptide Supplement on the Epidermal Skin Barrier

김정기,; 이지해,; 배일홍,; 서대방,; 이상준,

doi:10.9721/kjfst.2011.43.4.458

Cited by 20 publications

(19 citation statements)

References 11 publications

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“…Epidermal homeostasis means that keratinocytes undergo differentiation to form a skin barrier called the SC and to continuously maintain the permeability barrier function [54]. Skin diseases such as AD are caused by abnormalities in the physiological balance required to maintain epidermal homeostasis [55]. In particular, the ECS is intervened in the regulation of skin homeostasis by modulating cell growth, differentiation, and immune and inflammatory responses [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

Ahn

Yang

Park

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to investigate the efficacy of Hataedock (HTD) on skin barrier maintenance through the endocannabinoid system (ECS) intervention in Dermatophagoides farinae-induced atopic dermatitis (AD) NC/Nga mice. Douchi (fermented Glycine max Merr.) extracts prepared for HTD were orally administered to NC/Nga mice at a 20 mg/kg dose. Then, Dermatophagoides farinae extract (DfE) was applied to induce AD-like skin lesions during the 4th–6th and 8th–10th weeks. Changes in the epidermal structure of the mice were observed by histochemistry, immunohistochemistry, and TUNEL assay. The results showed that HTD significantly reduced the clinical scores (p<0.01) and effectively alleviated the histological features. In the experimental groups, increased expression of cannabinoid receptor type (CB) 1, CB2, and G protein-coupled receptor 55 (GPR55) and distribution of filaggrin, involucrin, loricrin, and longevity assurance homolog 2 (Lass2) indicated that HTD maintained the epidermal barrier through intervening in the ECS. The expression of E-cadherin and glutathione peroxidase 4 (GPx4) was increased, and the levels of cluster of differentiation 1a (CD1A) were low. Moreover, the apoptosis of inflammatory cells was elevated. The production of phosphorylated extracellular signal-related kinase (p-ERK), phosphorylated c-Jun amino-terminal kinase (p-JNK), and phosphorylated mammalian target of rapamycin (p-mTOR) was low, and epidermal thickness was decreased. Besides, the expression levels of involucrin were measured by treating genistein, an active ingredient of Douchi extract, and palmitoylethanolamide (PEA), one of the ECS agonists. The results showed that genistein had a better lipid barrier formation effect than PEA. In conclusion, HTD alleviates the symptoms of AD by maintaining skin homeostasis, improving skin barrier formation, and downregulating inflammation, through ECS intervention.

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Section: Discussionmentioning

confidence: 99%

Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

Ahn

Yang

Park

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Section: Assessment Of In-vivo Anti-photoaging Effectmentioning

confidence: 99%

“…Collagen slows down the generation of wrinkles and a decrease in skin elasticity caused by UV light and restores the damaged dermal layer (Kim et al, 2011), and the intake of collagen increases the thickness of the dermal layer and eases pigmentation (Jeon and Kang, 2009). It was also reported that the intake of collagen peptides protects skin barriers (Kim et al, 2011). Collagen is an important constituent that forms the skeletal system of vertebrate and invertebrate animals, and, in particular, collagen is an important fiber protein that composes mammals' skin, cartilage, tissue and tendon (Pei et al, 2000), but the synthesis of collagen decreases and matrix metallo proteinases (MMPs) that degrade collagen increases with age (Banning, 2008).…”

Section: Assessment Of In-vivo Anti-photoaging Effectmentioning

confidence: 99%

“…The oral intake of collagen is also known to strengthen and shine hair and finger and toe nails. Kim et al (2009) observed the protecting effect of collagen peptide compounds against skin damage such as the loss of skin moisture induced through the in-vivo UV treatment for 10 weeks, and reported that the intake of the compounds eased symptoms caused by the UV treatment such as the increasing number of wrinkles, the reduced elasticity of the skin, the increasing proliferation of abnormal horny cells and thus the increasing thickness of the skin, and that collagen peptide compounds protect the skin from UV, improve the elasticity and moisturizing ability of the skin, and thus contributes to the normal functioning of the skin (Kim et al, 2009). It was also reported that collagen peptides increased the diameter and density of dermal collagen fibers in vivo, and that the oral intake of collagen peptides improved the skin in an in-vivo photoaging model (Shigemura et al, 2009;Kikuta et al 2003;Sibilla et al, 2015).…”

Section: Assessment Of In-vivo Anti-photoaging Effectmentioning

confidence: 99%

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Inhibitory Effects of Collagen Coated Coffee Bean Intake on Skin Aging

Lee¹,

Ha²,

Shin³

2019

J. People Plants Environ

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To evaluate the protective effect of collagen peptide-coated coffee extract on skin aging, cell viability was measured with a MTT assay using cultured CCD-986sk fibroblasts, and its effect on wrinkles in the skin of hairless mice induced by UVB-irradiation was examined. In addition, its effect on procollagen synthesis and anti-oxidative, and its inhibitory activity against collagenase, elastase, tyrosinase and MMP-1 were analysed. After the 30-minute topical treatment, the animals were exposed to UVB irradiation (60-100 mJ/cm 2) for 4 weeks and its intensity increased during the period. Under the experimental conditions set in this study, the skin thickness of hairless mice significantly decreased (11.8-21.3%) compared to the control group. Based on these results, the prolonged oral intake of a collagen peptide mixture with coffee is expected to significantly increase the synthesis of procollagen in dermal fibroblasts, thereby contributing to the alleviation of wrinkling and lowered elasticity due to structural damage to the dermal layer caused by UV. The oral intake of collagen-coated coffee contributes to increasing collagen biosynthesis in a dose-dependent manner and alleviates the symptoms of thickened keratin caused by UV irradiation. However, it did not inhibit the enzymes involved in skin aging, whitening, wrinkle improvement, and antioxidation. Based on the these results, it can be concluded that the intake of collagen peptide-coated coffee extract can be utilized as an alternative material for the prevention or treatment of diseases associated with photoaging.

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“…최근 들어 피부 주름 개선에 효과가 있는 화장품에 대한 관심 이 높아지면서 기능성 화장품 소재를 탐색하기 위한 연구가 활 발히 이루어 지고 있다 (Kim et al, 2009). 그 중 단백질 가수 분해물로부터 얻어진 펩타이드는 아미노산 서열이 가지는 배열 및 구조에 따라 생체 내 혹은 피부에서 생리활성을 가지게 되어 생물학적 제제로서의 산업적 응용 가능성이 높다 (Jung et al, 2015;Kim et al, 2009;Kim et al, 2016). 또한 최근에는 재조합 과정을 통해 합성된 펩타이드 연구가 활발히 이루어 지고 있는 추세이다 (Lupo & Cole, 2007 http://www.e-ajbc.org 상처 치유 등의 항노화를 유도한다 (Choung et al, 2013 (Figure 3).…”

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Anti-wrinkle and Skin turnover Improvement Effects of Niacinamide-dipeptide Convergence

Kim¹,

Lee²,

Jeon³

et al. 2018

Asian J Beauty Cosmetol

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Purpose: This study aimed to determine the anti-wrinkle and skin turnover improvement effects of niacinamide-dipeptide convergence (N-peptide). Methods: The following methods were employed to assess the anti-wrinkle and skin turnover improvement effects of N-peptide: 3-(4,5-Dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay, wound healing assay, chicken chorioallantoic membrane (CAM) assay, reverse transcription polymerase chain reaction (RT-PCR), and three-dimensional (3D) cell culture. Results: The MTT assay revealed that the N-peptide does not exert a cytotoxic effect in human keratinocytes (HaCaT). Moreover, the scratch wound healing and CAM assays showed that the N-peptide induced migratory properties and angiogenesis, respectively, in HaCaT cells. The expression of matrix metalloproteinases (MMP)-1,-2,-3, and-9 was measured using RT-PCR to evaluate the anti-wrinkle effect of N-peptides. The findings demonstrated that N-peptides were responsible for reducing the expression of the aforementioned MMPs. In addition, using western blotting, N-peptides were identified to increase energy metabolism activity. Furthermore, 3D cell culture analysis indicated improvement in the skin turnover rate because of the N-peptides. Conclusion: Taken together, these results suggest that N-peptides may be a source of cosmetic agents for the improvement of wrinkles and skin turnover.

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Beneficial Effect of a Collagen Peptide Supplement on the Epidermal Skin Barrier

Cited by 20 publications

References 11 publications

Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

Inhibitory Effects of Collagen Coated Coffee Bean Intake on Skin Aging

Anti-wrinkle and Skin turnover Improvement Effects of Niacinamide-dipeptide Convergence

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