Beneficial effects of dietary acarbose in the streptozotocin-induced diabetic rat

Katovich, Michael J.; Meldrum, Michael J.; Vasselli, Joseph R.

doi:10.1016/0026-0495(91)90028-u

Cited by 24 publications

(15 citation statements)

References 29 publications

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“…(17) In rats with non-insulin-dependent diabetes, the treatment with acarbose accounted for a decrease in glomerulosclerosis and a significantly longevity (10) ; in alloxan-diabetic rats treated with acarbose plus insulin a correlation was found between better metabolic control and a decrease of retinal alterations. (18) The IAD rats showed the best results in urinary output, water intake, blood and urinary glucose, suggesting a synergistic effect of insulin and acarbose.…”

Section: Discussionmentioning

confidence: 98%

Role of metabolic control on diabetic nephropathy

et al. 2002

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Macedo CS, Capelletti SM, Mercadante MCS, Padovan CR, Spadella CT. Role of metabolic control on diabetic nephropathy. Acta Cir Bras [serial online] 2002 Nov-Dec;17(6). Available from URL: http://www.scielo.br/acb. ABSTRACT -Objective: The aim of this investigation was studying the influence of glucose metabolic control on diabetic nephropathy. The authors observed the effect of acarbose, insulin, and both drugs on the metabolic control and development of mesangial enlargement of kidney glomeruli in alloxan-diabetic rats. Methods: Five groups of Wistar rats were used: normal rats (N), non-treated alloxan-diabetic rats (D), alloxan-diabetic rats treated with acarbose (AD), alloxandiabetic rats treated with insulin (ID), and alloxan-diabetic rats treated with insulin plus acarbose (IAD). The following parameters were evaluated: body weight; water and food intake; diuresis; blood and urine glucose levels; and the kidney lesions: mesangial enlargement and tubule cell vacuolization. Renal lesions were analysed using a semi-quantitative score 1, 3, 6, 9, and 12 months after diabetes induction. Results: Diabetic rats showed a marked increase of glycemia, urinary glucose levels, diuresis, water and food intake, and weight loss, while the treated diabetic rats showed significant decreased levels of these parameters. The most satisfactory metabolic control was that of diabetic rats treated with acarbose + insulin. There was a significant mesangial enlargement in diabetic rats compared to normal rats from the third up to the 12 th month after diabetes induction, with a significant difference between the animals treated with acarbose + insulin and non-treated diabetic rats. A difference between the animals treated with acarbose or insulin alone and nontreated diabetics rats was not seen. Conclusions: The authors discuss the results stressing the role of diabetic metabolic control in the prevention of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 98%

Role of metabolic control on diabetic nephropathy

et al. 2002

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“…As could be expected from single-dose studies, elevated blood glucose concentrations and/or the urinary volume and glucose excretion and, last but not least, basal or prandial hyperinsulinaemia in diabetic rats and mice were dose dependently and markedly reduced by administration of acarbose (AXEN and SCLAFANI 1990;AXEN 1993;COHEN 1993;FOELLMER et al 1993;FRIEDMAN et al 1991;GRAY and OLEFSKY 1982;HAMADA et al 1989a;KATOVICH et al 1991;MAROT and LEMARCHAND-BRUSTEL 1988;PETERSON et al 1988;PETERSON 1991;PETERSON et al 1993;TULP et al 1988a;TuLP et al 1988b;TULP et al 1993;VASSELLI et al 1982;YAMASHITA et al 1984). Combined treatment of streptozotocin (STZ)-diabetic rats with insulin and acarbose was more effective than treatment with low-dosed insulin alone (HAMADA et al 1989b;KATOVICH and MELDRUM 1993a), as is indicated by ameliorated hyperglycaemia, polydipsia, urinary glucose excretion and glycated haemoglobin (GHb).…”

Section: Repeated Administrationmentioning

confidence: 85%

“…The concentration of norepinephrine and its potassiumstimulated release in the caudal tail artery of STZ-diabetic rats is higher than in non-diabetic rats. An 8-week treatment of STZ-diabetic rats with acarbose brought about a statistically significant reverse of both parameters in male rats (KATOVICH et al 1991) and a statistically insignificant reduction in female rats (KATOVICH and MELDRUM 1993a).…”

Section: Catecholamines and Thyroid Hormonesmentioning

confidence: 93%

“…When isoproterenol was injected into acarbose-treated male and female STZ-diabetic rats, the increase in tail-skin temperature was significantly improved in comparison to control animals, whereas the decreased isoproterenol-induced temperature increase in the colon of STZ-diabetic rats was not affected by acarbose (KATOVICH et al 1991;KATOVICH and MELD RUM 1993a).…”

Section: Catecholamines and Thyroid Hormonesmentioning

confidence: 94%

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Pharmacology of Glucosidase Inhibitors

Puls¹

1996

Oral Antidiabetics

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“…A kinetic study of GCs and Args was reported by Eloot et al [21]. These compounds were found to be distributed in the plasma, urine, kidneys and cerebrospinal fluid and were taken up by the choroid plexus and distributed in the cerebrum [22][23][24][25]. Urine samples are useful biological samples for clinical diagnosis to detect patient diseases, and can be collected in a convenient, non-invasive and chronologic manner.…”

Section: Calibration Range Equation Amentioning

confidence: 97%