Beneficial effects of docosahexaenoic acid on cognition in age‐related cognitive decline

Abstract

Clinicaltrials.gov, Identifier: NCT0027813.

Low Doses of Long-chain Polyunsaturated Fatty Acids Affect Cognitive Function in Elderly Japanese Men: A Randomized Controlled Trial

“…Significant increases in DHA 0.9 and ARA 0.6 contents in plasma phospholipids were observed in the LCPUFA group, although no significant changes were observed in the placebo group. The amounts of increases in DHA and ARA contents in plasma phospholipids are considered within a reasonable range, because the increase of DHA content was shown to be 3.2 with 900 mg/day of DHA supplementation 11 and the increase in ARA content was shown to be 0.7 and 2.5 with 80 mg/day and 240 mg/day of ARA supplementation, respectively 30,32 . On the other hand, there were no significant changes in DHA, EPA, or ARA intake from daily diets between baseline and 4 weeks after supplementation in each group.…”

Gut microbiota, the pharmabiotics they produce and host health

“…Furthermore, administration of B. breve NCIMB 702258 to mice had a significant impact on the fatty acid composition of the brain (81) . Mice that received the bacteria for 8 weeks exhibited higher concentrations of bioactive fatty acids, arachidonic acid and DHA, compared with unsupplemented controls (81) , whereby these bioactive fatty acids have a role in neurotransmission and protection against oxidative stress (168,169) . A broad range of microbes, either probiotics or commensals can manufacture and secrete neurochemicals which can positively impact on mental health and thus, could be used for the treatment of CNS disorders, such as anxiety and depression.…”

Long-chain Polyunsaturated Fatty Acid Supplementation Improves Mood in Elderly Japanese Men

“…Significant increases in DHA 0.8 and ARA 0.7 content in plasma phospholipids were observed in the LCPUFA group, although no significant changes were observed in the placebo group. The increase in DHA and ARA content in plasma phospholipids is considered to be within a reasonable range, because the increase in DHA content was 3.2 with 900 mg/day DHA supplementation 25 , and the increases in ARA content were 0.7 and 2.5 with 80 mg/day and 240 mg/day ARA supplementation, respectively 26,27 . The EPA content in plasma phospholipids was likely not affected by the dose or the combination of LCPUFA 300 mg/day DHA, 100 mg/day EPA, and 120 mg/day ARA supplementation in this study condition.…”