Beneficial effects of fish and fish peptides on main metabolic syndrome associated risk factors: Diabetes, obesity and lipemia

Abachi, Soheila; Pilon, Geneviève; Marette, André; Bazinet, Laurent; Beaulieu, Lucie

doi:10.1080/10408398.2022.2052261

“…Many research indicated that bioactive fish proteins or peptides tend to be present as oligo-peptides with low molecular weight and contain 2 to 20 amino acid residues (near 3 kDa). 3,4 This result suggested that although the majority of molecules of perch essences are proteins determined by the colorimetric method as in Table 1, the high inhibitory activity of perch essences on digestive enzymes might be related to the presence of these smaller molecular proteins or peptides with a molecular weight of less than 2.3 kDa. The metabolic health effects of a fish protein depend on several factors, such as the amino acid composition of the protein, the steric structure of the protein, and chemical changes of the protein during processing.…”

Section: Resultsmentioning

confidence: 96%

“…As most of the fish proteins that are effective anti-Mets are bio-peptides with molecular weights below 1000. 4,17 To investigate why perch has the highest activity, this study further analyzed the molecular weight distribution of perch essences using gel filtration chromatography. The perch essences with molecular weight less than 1.2 kDa accounted for the total protein was 22.6% from the results of protein profile analysis in Table 4.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, fish products are potential therapy candidates for prevention and treatment risk factors. 4 However, herein beneficial effects of various fish species on metabolic dysfunction are required for further comprehensively discussed. Mackerel, milkfish, and perch, rich in biologically active amino acids and protein, are three popular fish species in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The protein profile of perch essence and its improvement of metabolic syndrome in vitro

Lin¹,

Chang²,

Chang³

et al. 2022

MOJFPT

1

5

0

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The objective of this study was to analyze the protein profile and amino acid composition of perch essence processed by high-pressure extraction compared with mackerel, and milkfish. The inhibitory activities of three essences were determined against digestive enzymes relevant to the metabolic syndrome such as the angiotensin-converting enzyme (ACE), pancreatic lipase, α-amylase, and α-glucosidase. The results showed that perch essence exhibits the highest recovery by using the same extraction method for all three fish species. The amounts of all hydrolyzed amino acids, except histidine, were approximately double in perch compared with the other two fish. The perch essence contained the most abundant soluble protein and amino acids composition related to metabolic syndrome. In vitro anti-hypertensive, hypoglycemic, and anti-obesity potency of perch essence exhibited the highest among the three fishes. Although the amounts of free amino acids were similar in the three fish species, the molecular weight distribution from gel filtration chromatographic analysis indicated that perch essence contained 32.4% of peptides with a molecular weight of less than 2.3 kDa. This study suggested that naturally occurring bioactive peptides in perch essence might potentially serve as a good source of functional food supplements for metabolic syndrome.

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“…Fatty acids play an important role as a source of metabolic energy in fish growth [ 66 ]. However, the abnormal lipid metabolism in fish is a risk factor for diabetes, hyperlipidemia, and metabolic diseases [ 67 , 68 ]. In recent years, several studies have demonstrated the positive role of CNE in the treatment of lipid metabolism disorders.…”

Section: Discussionmentioning

confidence: 99%

Dietary Cinnamaldehyde Enhances Growth Performance, Digestion, Immunity, and Lipid Metabolism in Juvenile Fat Greenling (Hexagrammos otakii)

Gu

¹

,

Han

²

,

Wang

³

et al. 2022

Aquaculture Nutrition

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Fat greenling (Hexagrammos otakii) is a kind of economic fish that is widely consumed by human, and its intensive farming technology is making important progress. However, high-density farming may cause the occurrence of diseases in H. otakii. Cinnamaldehyde (CNE) is a new feed additive for aquatic animals and has a positive effect on disease resistance. In the study, dietary CNE was evaluated on the growth performance, digestion, immune response, and lipid metabolism of juvenile H. otakii ( 6.21 ± 0.19 g). Six experimental diets were formulated containing CNE at levels of 0, 200, 400, 600, 800, and 1000 mg/kg for 8 weeks. The percent weight gain (PWG), specific growth rate (SGR), survival (SR), and feeding rate (FR) were significantly increased by including CNE in fish diets regardless of the inclusion level ( P < 0.05 ). The feed conversion ratio (FCR) was significantly decreased among the groups fed CNE supplemented diets ( P < 0.05 ). A significant decrease in hepatosomatic index (HSI) was observed in fish fed 400 mg/kg-1000 mg/kg CNE compared to the control diet ( P < 0.05 ). Fish-fed diets containing 400 mg/kg and 600 mg/kg CNE had a higher level of crude protein in muscles than the control diet ( P < 0.05 ). Moreover, the activities of lipase (LPS) and pepsin (PEP) in the intestinal were markedly increased in juvenile H. otakii-fed dietary CNE ( P < 0.05 ). Apparent digestibility coefficient (ADC) of dry matter, protein, and lipid was significantly increased with CNE supplement ( P < 0.05 ). The activities of catalase (CAT) and acid phosphatase (ACP) in the liver were markedly enhanced by including CNE in juvenile H. otakii diets compared with the control ( P < 0.05 ). The activities of superoxide dismutase (SOD) and alkaline phosphatase (AKP) in the liver were markedly enhanced in juvenile H. otakii treated with CNE supplements 400 mg/kg-1000 mg/kg ( P < 0.05 ). Additionally, the levels of total protein (TP) in the serum were markedly increased by including CNE in juvenile H. otakii diets compared with the control ( P < 0.05 ). In the CNE200, CNE400, and CNE600 groups, albumin (ALB) levels in the serum were markedly higher compared with that in the control ( P < 0.05 ). In the CNE200 and CNE400 groups, the levels of immunoglobulin G (IgG) in the serum were significantly increased compared with that the control group ( P < 0.05 ). The juvenile H. otakii-fed dietary CNE had lower triglycerides (TG) and total cholesterol (TCHO) levels in the serum than fish-fed CNE-free diets ( P < 0.05 ). The gene expression of peroxisome proliferator-activated receptor alpha (PPAR-α), hormone-sensitive lipase (HSL), and carnitine O-palmitoyltransferase 1 (CPT1) in the liver was significantly increased by including CNE in fish diets regardless of the inclusion level ( P < 0.05 ). However, fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPAR-γ), and acetyl-CoA carboxylase alpha (ACCα) in the liver were markedly decreased with CNE supplements 400 mg/kg-1000 mg/kg ( P < 0.05 ). The glucose-6-phosphate1-dehydrogenase (G6PD) gene expression levels in the liver were markedly decreased compared with the control ( P < 0.05 ). The optimal supplementation level of CNE was shown by curve equation analysis to be 590.90 mg/kg.

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“…Peptide research is suspected to have a physiological mechanism of action and does not cause side effects, and is strongly suspected to have the potential to prevent the development of pathological processes during COVID-19 by inhibiting the SARS-CoV-2 viral protein, so that it has immunoprotective and bronchoprotective effects on lung cells, and normalizes the state of the immune system and hemostatic system, such as antimicrobial peptides [2]. Moreover, in 2022, researchers have been discovered beneficial effect of fish peptides for drugs degenerative diseases (anti-obesogenic, hypoglycemic, hypercholesterolemic and hypolipidemic) [1,26]. Conventional antibiotic compounds are basically synthetic types of peptides, and resistance to their use are found, so it is necessary to find a new sources of natural peptides (i.e marine peptides), so that they can overcome conventional antibiotic resistance cases.…”

Section: Introductionmentioning

confidence: 99%

Comparison of characteristics between peptides in fish meat and fermented products

Viruly

¹

,

Prymasari

²

,

Agustina

³

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

1

0

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In the pasca of the COVID-19 pandemic, many researchers have focused on finding drugs for the COVID-19. Peptide research is predicted to have a physiological mechanism of action and it does not cause side effects, therefore it is necessary to search for peptide sources. The aim of this study was to characterize peptides extracted from tamban fish (Sardinella fimbriata) and fermented products (Cincalok of Tanjungpinang). Peptide extract was obtained by maceration extraction using 95% PA (1:5) ethanol solvent, and then it filtered using MWCO 3 kDa and 10 kDa. The amino acid characteristics of the peptides was obtained using HPLC. Peptides of tamban fish had the pH of 7.6 and they are rich of amino acid histidine (890.18 mg/L), in addition to the amino acids glutamate, tyrosine, glycine, leucine, alanine, and aspartic acid. But the peptides of the fermented cincalok product had the pH of 6.4 and they are rich of amino acid leucine (1066.83 mg/L), in addition to the amino acids glutamate, valine, isoleucine, and alanine. Each of these peptides had the molecular weight of 10 kDa. The results of this study can be used as preliminary information to the pharmaceutical development of a new source of peptides.

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Beneficial effects of fish and fish peptides on main metabolic syndrome associated risk factors: Diabetes, obesity and lipemia

Cited by 11 publications

References 277 publications

The protein profile of perch essence and its improvement of metabolic syndrome in vitro

The protein profile of perch essence and its improvement of metabolic syndrome in vitro

Dietary Cinnamaldehyde Enhances Growth Performance, Digestion, Immunity, and Lipid Metabolism in Juvenile Fat Greenling (Hexagrammos otakii)

Comparison of characteristics between peptides in fish meat and fermented products

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