Beneficial effects of Glycyrrhizae radix extract in preventing oxidative damage and extending the lifespan of Caenorhabditis elegans

Ruan, Qiurong; Qiao, Yan; Zhao, Yunli; Xu, Yun; Wang, Meng; Duan, Jin‐Ao; Wang, Dayong

doi:10.1016/j.jep.2015.10.008

Cited by 51 publications

(30 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glycyrrhizae radix (GR) is usually used in combination with other Chinese herbal medicines to treat peptic ulcers, hepatitis C, and skin diseases [ 59 – 62 ]. Recent studies have shown that the long-term exposure to GR can prolong the lifespan of nematodes, enhance their motor capacity, and reduce intestinal ROS production [ 30 ]. In addition, the GR treatment alters the expression pattern of genes encoding insulin-like signaling pathways, which play a key role in longevity control [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…rough a systematic review of 20 studies, we have found that most of the antiaging effects of TCM are involved in the IIS pathway. Coix seed essential oil, clove essential oil, Lonicera japonica crude extractions, Glycyrrhizae Radix crude extractions, Gengnianchun aqueous extractions, Rehmannia glutinosa neutral polysaccharides, Lycium barbarum neutral polysaccharides, juniper berry (Juniperus communis L.) essential oil, Zanthoxyllum aramatum natural flavonol, Hibiscus sabdariffa L., Polygonum multiflorum aqueous extract, and Astragalus Evidence-Based Complementary and Alternative Medicine membranaceus astragaloside IV (AS-IV) can all increase the expression of daf-16 [22][23][24][25][26][27][28][29][30][31][32]34]. Hsf-1 expression in C. elegans was increased after treatment with coix seed essential oil and Lonicera japonica crude extractions [23,24].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

Wang

Zuo

Ouyang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Aging is an inevitable stage of body development. At the same time, aging is a major cause of cancer, cardiovascular disease, and neurodegenerative diseases. Chinese herbal medicine is a natural substance that can effectively delay aging and is expected to be developed as antiaging drugs in the future. Aim of the review. This paper reviews the antiaging effects of 23 traditional Chinese herbal medicines or their active components. Materials and methods. We reviewed the literature published in the last five years on Chinese herbal medicines or their active ingredients and their antiaging role obtained through the following databases: PubMed, EMBASE, Scopus, and Web of Science. Results. A total of 2485 papers were found, and 212 papers were screened after removing the duplicates and reading the titles. Twenty-three studies met the requirements of this review and were included. Among these studies, 13 articles used Caenorhabditis elegans as the animal model, and 10 articles used other animal models or cell lines. Conclusion. Chinese herbal medicines or their active components play an antiaging role by regulating genes related to aging through a variety of signaling pathways. Chinese herbal medicines are expected to be developed as antiaging drugs or used in the medical cosmetology industry.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

Wang

Zuo

Ouyang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…In addition, it has antioxidant properties [ 16 ]. These four herbal medicines exhibit a reproductive effect in mice [ 17 ], a stimulatory effects on splenocytes [ 18 ], anti-melanogenesis activity against melanoma cells [ 19 ], and the ability to extend the lifespan of C. elegans [ 20 ]. In the present study, we analyzed 7 marker compounds found in an SGT-4 ginsenoside Rg1, ginsenoside Rb1, atractylenolide III, liquiritigenin, liquiritin apioside, liquiritin, and glycyrrhizin using HPLC analysis (Fig.…”

Section: Discussionmentioning

confidence: 99%

High–efficiency generation of induced pluripotent stem cells from human foreskin fibroblast cells using the Sagunja-tang herbal formula

Kim¹,

Heo²,

Lee³

et al. 2017

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundSagunja-Tang (SGT-4) is a traditional herbal formula in Korean medicine that is used to treat anti-metabolic syndrome, and has antioxidant activity. In this study, we evaluated the effects of SGT-4 on the formation efficiency of induced pluripotent stem cells (iPSCs) from human foreskin fibroblasts (HFFs) by four reprogramming transcription factors: Oct4, Sox2, KIf4, and c-Myc (OSKM).MethodsSGT-4 contained four different herbal medicines that are composed of Ginseng Radix, Glycyrrhizae Radix et Rhizoma, Atractylodis Rhizoma Alba, and Poria Sclerotium. The composition of SGT-4 was analyzed by high-performance liquid chromatography (HPLC). HFFs were transfected with episomal vectors contained by four OSKM. Western blotting, RT-PCR, immunofluroescence, and in vitro differentiation were used to assess the pluripotency of the iPSC cells.ResultsSGT-4 exhibited antioxidant activity against the generation of intracellular reactive oxygen species (ROS) as well as promoted the activation of superoxide dismutase 1 (SOD1), catalase, gluthathione peroxidase 1 (GPX1), and glutathione (GSH). Moreover, the ATP level was not significantly fluctuated depending on the concentration of SGT-4 in the hiPSCs.ConclusionOur results indicate that the SGT-4, herbal formula significantly increases the efficiency of human iPSC generation via the transcription factors (Oct4, Sox2, KIf4, and c-Myc).

show abstract

“…To test whether gliadin treatment increases ROS levels in C. elegans , ROS production was measured as described previously [15,23]. The animals were transferred to 1 mL of M9 buffer containing 1 µM of 2′,7′-dichlorodihydrofluorescein diacetate (DCFDA) (Sigma-Aldrich, St. Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in A Caenorhabditis Elegans Model

et al. 2019

View full text Add to dashboard Cite

Gliadin is a major protein component of gluten and causes gluten toxicity through intestinal stress. We previously showed that gliadin intake induces oxidative stress in the intestine and reduces fertility in a Caenorhabditis elegans model. To elucidate the possible link between intestinal stress and reproduction, changes in the intestine and germ cells of C. elegans after gliadin intake were examined at the molecular level. Gliadin intake increased reactive oxygen species (ROS) production in the intestine, decreased intestinal F-actin levels, and increased germ cell apoptosis. These gliadin-triggered effects were suppressed by antioxidant treatment. These results suggest that ROS production in the intestine induced by gliadin intake causes disruption of intestinal integrity and increases germ cell apoptosis. Gliadin-induced germ cell apoptosis (GIGA) was suppressed by depletion of cep-1, ced-13, egl-1, or mpk-1. However, HUS-1 was not activated, suggesting that GIGA is activated through the mitogen-activated protein kinase (MAPK) pathway and is CEP-1-dependent but is a separate pathway from that controlling the DNA damage response. Taken together, our results suggest that gliadin causes intestinal barrier disruption through ROS production and interacts with the germ cells to reduce fertility through GIGA.

show abstract

Beneficial effects of Glycyrrhizae radix extract in preventing oxidative damage and extending the lifespan of Caenorhabditis elegans

Cited by 51 publications

References 55 publications

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

High–efficiency generation of induced pluripotent stem cells from human foreskin fibroblast cells using the Sagunja-tang herbal formula

Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in A Caenorhabditis Elegans Model

Contact Info

Product

Resources

About