Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome

The Effects of Malaysian Herb, Labisia pumila var. alata on Oestrous Cyclicity and Reproductive Parameters of Nulliparous Rats

“…Other studies also stated that rats with polycystic ovaries demonstrated a reduction trend in estrogen and progesterone levels but increased in androgens (Manneras et al 2007) when compared to the control intact females. As being reported to show estrogenic effects (Manneras et al 2010), LPA in the present study had also increased the oestradiol levels of rats receiving higher doses but however, this was not statistically significant. Additionally, the free testosterone level also showed an increment as the dose increased.…”

The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis

“…The water extracts of LPva were able to displace estradiol bound to estrogen receptors (Husniza, 2002). Furthermore, LPva increased uterine weight in ovariectomised and dihydrotestoterone-induced polycystic ovarian syndrome rats, thus exhibiting estrogenic properties (Fazliana et al, 2009;Manneras et al, 2010). LPva was also able to initiate lipolysis in adipose tissue in a manner similar to that reported for estrogen (Ayida et al, 2007).…”

Potential Role of Labisia pumila in the Prevention and Treatment of Chronic Diseases

“…The study by Fazliana et al showed that Labisia pumila appears to show promising results in regulating body weight through the secretion of leptin and thus might affect insulin sensitivity (Fazliana et al, 2009). The effect of Labisia pumila in polycystic ovarian syndrome (PCOS) rats induced with dihydrotestosterone was also studied (Manneras et al, 2010) based on the results by the study done by Fazliana et al (Fazliana et al, 2009). PCOS is an endocrine and metabolic disorder that is associated with obesity, insulin resistance and type 2 diabetes.…”

“…After treatment with Labisia pumila, the Polycystic Ovarian Syndrome (PCOS) rats also had decreased levels of Total Cholesterol and triglyceride levels. However, there were no changes seen in High Density Lipoprotein -C (HDL-C) and Low Density Lipoprotein-C (LDL-C) levels (Manneras et al, 2010). A study done by Azidah et al in human trials also showed that there was beneficial effect of Labisia pumilavar alata in reducing triglyceride level in postmenopausal women (Azidah et al, 2012).…”