Beneficial Regulation of Matrix Metalloproteinases for Skin Health

Philips, Neena; Auler, Susan; Hugo, Raul; González, Salvador

doi:10.4061/2011/427285

Cited by 90 publications

(86 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Skin and scale regeneration in fish involves, re-epithelialization and differentiation of scale-forming cells (day 1–2), production of the external layer matrix (days 3–5), production of the basal-plate matrix (days 6–14) and finally partial mineralization of the basal plate (days 14–28) [12]. Wound repair and skin regeneration studies are numerous in mammals [13, 14] and amphibians [15, 16], but are much less frequent in the fishes, the largest group of extant vertebrates [17] and the molecular basis of skin repair is generally restricted to single gene studies [18–21]. Recent studies have used microarrays to assess the response of fish skin to damage or ectoparasites [8, 22] and members of the angiopoietin family are among the differentially expressed genes detected.…”

Section: Introductionmentioning

confidence: 99%

Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration

2017

View full text Add to dashboard Cite

BackgroundThe skin in vertebrates is a protective barrier and damage is rapidly repaired to re-establish barrier function and maintain internal homeostasis. The angiopoietin-like (ANGPTL) proteins are a family of eight secreted glycoproteins with an important role in skin repair and angiogenesis in humans. In other vertebrates their existence and role in skin remains largely unstudied. The present study characterizes for the first time the homologues of human ANGPTLs in fish and identifies the candidates that share a conserved role in skin repair using a regenerating teleost skin model over a 4-day healing period.ResultsHomologues of human ANGPTL1-7 were identified in fish, although ANGPTL8 was absent and a totally new family member designated angptl9 was identified in fish and other non-mammalian vertebrates. In the teleost fishes a gene family expansion occurred but all the deduced Angptl proteins retained conserved sequence and structure motifs with the human homologues. In sea bream skin angptl1b, angptl2b, angptl4a, angptl4b and angptl7 transcripts were successfully amplified and they were differentially expressed during skin regeneration. In the first 2 days of skin regeneration, re-establishment of the physical barrier and an increase in the number of blood vessels was observed. During the initial stages of skin regeneration angptl1b and angptl2b transcripts were significantly more abundant (p < 0.05) than in intact skin and angptl7 transcripts were down-regulated (p < 0.05) throughout the 4-days of skin regeneration that was studied. No difference in angptl4a and angptl4b transcript abundance was detected during regeneration or between regenerating and intact skin.ConclusionsThe angptl gene family has expanded in teleost genomes. In sea bream, changes in the expression of angptl1b, angptl2b and angptl7 were correlated with the main phases of skin regeneration, indicating the involvement of ANGPTL family members in skin regeneration has been conserved in the vertebrates. Exploration of the fish angptl family in skin sheds new light on the understanding of the molecular basis of skin regeneration an issue of importance for disease control in aquaculture.Electronic supplementary materialThe online version of this article (doi:10.1186/s12862-016-0859-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration

2017

View full text Add to dashboard Cite

show abstract

“…The expression of MMPs is also influenced by numerous factors, e.g. the transformation of cells, hormones (depending on the cell type), some cytokines (such as IL-1 or IL-6), or growth factors (such as epidermal growth factor [EGF] or transforming growth factor-beta [TGF-β]) [29].…”

Section: The Regulation Of Mmpsmentioning

confidence: 99%

The Significance of Matrix Metalloproteinases in Oral Diseases

et al. 2015

View full text Add to dashboard Cite

MMPs are significant in the physiological processes of embryo development, wound healing and differentiation related to tissue remodeling. However, the overexpression of several MMPs is involved in tumor invasion, metastasis, disregulated angiogenesis, inflammation and even cell destruction [1,[5][6][7][8][9]. MMP SubfamiliesThe first metalloproteinase was discovered in 1962 during a study of the ECM degradation re- The Role of MMPsMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. These activities are implicated in a number of essential physiopathological processes AbstractMatrix metalloproteinases (MMPs) belong to a family of structurally related zinc-dependent proteolytic enzymes that are known to play a key role in the catabolic turnover of extracellular matrix (ECM) components. Research studies to date have indicated that MMPs regulate the activity of several non-ECM bioactive substrates, including growth factors, cytokines, chemokines and cell receptors, which determine the tissue microenvironment. Disruption of the balance between the concentration of active matalloproteinases and their inhibitors (TIMPs) may lead to pathological changes associated with uncontrolled ECM turnover, tissue remodeling, inflammatory response, cell growth and migration. This brief review presents some information on MMPs' role in inflammatory, metabolic and cancer abnormalities related to the salivary glands, as well as MMP-related aspects that lead to the formation of human dentinal caries lesions. In oral diseases, the most relevant biological fluid commonly used for diagnosing periodontal diseases is saliva. In diseased patients with significantly higher levels of MMPs in their saliva than healthy people, most extracellular matrix components undergo digestion to lower molecular weight forms. Conventional treatment successfully reduces the levels of MMPs inhibits the progressive breakdown of gingival and periodontal ligament collagens. Beside inflammatory abnormalities like Sjögren's syndrome (SS), a large group of disorders is comprised of cancers, most of them involving the parotid gland (Adv Clin Exp Med 2016, 25, 2, 383-390).

show abstract

“…While low intensity LED did not markedly decrease the expression of these genes, exposure to 47.5 µW/cm 2 of 633-nm LED irradiation for 2 days (maximum dose used in this study) decreased the levels of MMP1 and MMP2 by 24 and 29%, respectively. Indeed, MMPs are essential to epidermal (keratinocyte) differentiation and the prevention of wound scars, indicating that the excessive loss of MMPs yields rather harmful effects on skin integrity (25). In addition, such a loss in MMP expression induces keratinocyte hyperproliferation, which is one of the main characteristics of aged skin (26,27).…”

Section: Discussionmentioning

confidence: 99%

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells

Kim

Park

Baek

et al. 2014

International Journal of Molecular Medicine

View full text Add to dashboard Cite

Abstract. Accumulating evidence has indicated that the light source emitted from light-emitting diode (LED) has a potential anti-aging effect on human skin. Studies using single and interval LED irradiation have documented such effects; however, to the best of our knowledge, the anti-aging effects of continuous LED irradiation have not yet been investigated. In the present study, we demonstrated that continuous irradiation with a 633±3-nm LED exerted anti-aging effects in both in vitro and ex vivo experiments. More specifically, irradiation with a 633-nm LED for 2 days increased the synthesis of type 1 procollagen and decreased the expression of matrix metalloproteinase (MMP)1 and MMP2 in skin fibroblasts. In addition, irradiation with a 633-nm LED decreased the expression levels of inflammatory genes, such has cyclooxygenase-2 (COX-2), and interleukin-1-α (IL-1α) in keratinocytes. Furthermore, a 14-day LED irradiation moderately increased keratinocyte proliferation. Using human skin explants, we confirmed the safety of this 633-nm LED irradiation, which resulted in unaltered morphology and allergy-free potential in human tissue. Overall, these data provide insight into the anti-aging effects of continuous LED irradiation on human skin.

show abstract

Beneficial Regulation of Matrix Metalloproteinases for Skin Health

Cited by 90 publications

References 31 publications

Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration

Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration

The Significance of Matrix Metalloproteinases in Oral Diseases

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells

Contact Info

Product

Resources

About