Beneficial role of insect-derived bioactive components against inflammation and its associated complications (colitis and arthritis) and cancer

Dutta, Partha; Sahu, Ravi Kumar; Dey, Tushar Kanti; Lahkar, Manisha Datta; Manna, Prasenjit; Kalita, Jatin

doi:10.1016/j.cbi.2019.108824

Cited by 53 publications

(41 citation statements)

References 49 publications

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“…Cecropin is the most famous family of AMPs from insects, and it can be found in guppy silkworm, bees, Drosophila. Cecropin A shows activity against different inflammatory diseases and cancers (Dutta et al, 2019). What should be known is that the number of AMPs varies greatly between species, for example, invasive harlequin ladybird (Harmonia axyridis) and black soldier fly (Hermetia illucens) have up to 50 AMPs, while pea aphid (Acyrthosiphon pisum) lacks AMPs (Shelomi et al, 2020).…”

Section: Insect-derived Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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Antimicrobial peptides (AMPs) are a class of small peptides that widely exist in nature and they are an important part of the innate immune system of different organisms. AMPs have a wide range of inhibitory effects against bacteria, fungi, parasites and viruses. The emergence of antibiotic-resistant microorganisms and the increasing of concerns about the use of antibiotics resulted in the development of AMPs, which have a good application prospect in medicine, food, animal husbandry, agriculture and aquaculture. This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved. The research progress on antivirus peptides, especially anti-coronavirus (COVID-19) peptides, has been introduced given the COVID-19 pandemic worldwide in 2020.

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Section: Insect-derived Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

et al. 2020

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“…Another group is insect bioactive peptides reducing inflammation [ 130 ]. These peptides have the ability to inhibit lipoxygenase and cyclooxygenase-2 activity.…”

Section: New Alternative Sources Of Peptidesmentioning

confidence: 99%

Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

Jakubczyk

Karaś

Rybczyńska‐Tkaczyk

et al. 2020

Foods

164

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Generally, bioactive peptides are natural compounds of food or part of protein that are inactive in the precursor molecule. However, they may be active after hydrolysis and can be transported to the active site. Biologically active peptides can also be synthesized chemically and characterized. Peptides have many properties, including antihypertensive, antioxidant, antimicrobial, anticoagulant, and chelating effects. They are also responsible for the taste of food or for the inhibition of enzymes involved in the development of diseases. The scientific literature has described many peptides with bioactive properties obtained from different sources. Information about the structure, origin, and properties of peptides can also be found in many databases. This review will describe peptides inhibiting the development of current diseases, peptides with antimicrobial properties, and new alternative sources of peptides based on the current knowledge and documentation of their bioactivity. All these issues are part of modern research on peptides and their use in current health or technological problems in food production.

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“…The insect bioactive peptides and lipids have beneficial effects on human health, such as antioxidant, antimicrobial and antidiabetic properties, angiotensin I converting enzyme (ACE) inhibition activity, effects against inflammation and cancer. Insects can be also used as functional food ingredients (Dutta et al, 2019;da Silva Lucas et al, 2020).…”

Section: Insect-based Food Perspectives In Human Nutritionmentioning

confidence: 99%

Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario

et al. 2021

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Antibiotic misuse is greatly contributing to an increase in antimicrobial resistance (AMR) in humans and animals. Natural and synthetic alternative strategies are being investigated in human and veterinary medicine, but little attention is paid to the antimicrobial effects of edible lipids, such as medium-chain fatty acids (MCFAs) and monoglycerides. Among MCFAs, lauric acid (LA) and its monoglyceride derivative, glycerol monolaurate (GML), exhibit the strongest antimicrobial activity. Coconut and palm kernel oils are considered the main sources of LA. On the other hand, some edible insects (e.g., Hermetia illucens) are gaining interest as novel feed ingredients, due to the high amount of LA they contain as well as their numerous bioactive components, which provide many additional benefits to animal health. Although the beneficial effect of both MCFAs and LA is gradually being recognized, their high content within insects and, consequently, their possible role as antimicrobials, has not been well-reported. This mini review focuses on the anti-infective effects of the insect-derived MCFAs LA and its derivatives. We emphasize the potential of insect lipids, compared to the other vegetable sources, in the current global scenario where a sustainable and circular economy is required. Finally, we critically discuss the use and the benefits of edible insects such as favorable options as feed and food from the perspective of animal and human nutrition.

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Beneficial role of insect-derived bioactive components against inflammation and its associated complications (colitis and arthritis) and cancer

Cited by 53 publications

References 49 publications

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

Current Trends of Bioactive Peptides—New Sources and Therapeutic Effect

Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario

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