Benefits of Oral and Topical Administration of ROQUETTE Chlorella sp. on Skin Inflammation and Wound Healing in Mice

Abstract

The human body is constantly exposed to the risk of traumatic lesions. Chlorella is a green microalgae enriched with nutrients, vitamins, minerals and chlorophyll. In some communities, Chlorella is a traditional medicinal plant used for the management of inflammation-related diseases. ROQUETTE Chlorella sp. (RCs) was investigated by oral administration (125, 250 and 500 mg/kg) and cutaneous application (2.5, 5.0 and 10.0%) to evaluate its impact in two dermatological disorder models in mice: skin inflammation and wound healing. For skin inflammation, it was administered during 14 days starting one week before the induction of chronic skin inflammation by repeated cutaneous application of 12-Otetradecanoylphorbol 13-acetate (TPA). For wound healing the microalgae was administered by topical application after scarification of the skin until complete wound healing. Results indicated that oral and topical administrations of the two higher doses of RCs had significant effects on macroscopic score of skin inflammation with an efficient effect on microscopic score with cutaneous application. The microalgae had also efficient effect on healing process and duration of wound healing for both administration routes and particularly at the two highest doses of RCs. These findings suggest that administration of RCs by both oral and topical routes appeared to have beneficial effects on skin lesions.

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

“…TPA-induced skin inflammation (↓) macroscopic score (↓) [24] Chlorella A Anti-skin aging Expression of MMP-1 (↓) type 1 pro-collagen / elastin ( ↑) [25] Chlorella vulgaris Anti-skin cancer…”

Treatment with Modified Extracts of the Microalga Planktochlorella nurekis Attenuates the Development of Stress-Induced Senescence in Human Skin Cells

“…There is a limited number of studies reporting the promigratory and wound healing effects of Chlorella sp. extracts in vitro and in vivo [29][30][31]. Chlorella vulgaris dressing promoted wound closure and minimized the formation of scar tissue during the healing process compared to the control wounds created on the dorsal surface of rats [29].…”

“…Moreover, oral (500 mg/kg) and topical (10%) administration of ROQUETTE Chlorella sp. had beneficial effects on skin lesions in mice [30]. The wound healing potential of Arthrospira (Spirulina) platensis extract has also been compared to the wound healing potential of Chlorella vulgaris extract using human fibroblasts as a cellular model [31].…”

Protective effects of Hizikia fusiforme and Chlorella sp. extracts against lead acetate-induced hepatotoxicity in rats

“…Chlorella is a single-celled green alga rich in vitamins and minerals, and is effective in improving overall health and well-being. Chlorella contains a physiologically active substance, chlorella growth factor, which reportedly possesses anti-cancer effects and is effective in child growth and development as well as immune enhancement (Hidalgo et al 2014).…”