Benign Acute Childhood Myositis: Our Experience on Clinical Evaluation

D’Amico, Silvia; Gangi, Gloria; Barbagallo, M.; Palermo, Antonino; Finocchiaro, Maria Carla; Distefano, Antonella; Falsaperla, Raffaele; Marino, Silvia; Greco, Filippo; Smilari, Pierluigi; Pavone, Piero

doi:10.1055/a-1792-7606

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…3,21 In a study from Italy, 50 BACM patients were evaluated and no patient with recurrence was detected. 22 In the present study we did not have any patients with recurrence; this may be due to the low number of patients or the pandemic isolation (quarantine conditions).…”

Section: Discussionmentioning

confidence: 59%

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Öztürk

Göktüğ

Bodur

et al. 2022

Pediatrics International

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Background Benign acute childhood myositis (BACM) is associated with several viral infections. The aim of this study was to evaluate the progression of myositis symptoms, laboratory findings and oseltamivir treatment in children with influenza‐ and non‐influenza‐associated BACM. Methods Patients aged 0–18 years old, admitted to the pediatric emergency department in the seasonal influenza period between 2018 and 2020 were retrospectively analyzed. Patients with acute onset calf tenderness, pain, difficulty in walking and elevated serum creatine phosphokinase were included and were grouped according to influenza rapid test kit results as influenza (A and B) positive, and influenza negative. The time to symptom resolution, laboratory data and the oseltamivir treatment were compared between the groups. Results There were 94 patients (67 male, 27 female) with a mean age of 77 ± 22 months. Influenza A was detected in 21, influenza B in 27, and neither were detected in 46 patients. Time to symptom resolution of BACM was shorter in the influenza‐positive patients than in influenza‐negative patients (2.9 ± 1.4 days and 3.5 ± 1.5 days, respectively, P = 0.027). Oseltamivir did not reduce the symptom resolution time in influenza patients. All children had normal hemoglobin and platelet counts, elevated creatine phosphokinase and 76% of them had leukopenia. Neither clinical recurrence nor metabolic disease were reported. Conclusion Symptoms of BACM tended to resolve slightly earlier in influenza‐positive patients and the duration of symptoms was not affected by oseltamivir treatment.

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Section: Discussionmentioning

confidence: 59%

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Öztürk

Göktüğ

Bodur

et al. 2022

Pediatrics International

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“…ÇÇABM'de en sık başvuru sebebinin baldır ağrısı, yürüyememe ve yaygın kas ağrısı olduğu yapılan çalışmalarda bildirilmiştir (8,13,14). Hastalarımızın %92,2'sinde başvuru şikayeti literatürle uyumlu olarak üst solunum yolu enfeksiyonu belirtilerini takiben gelişen yürüyememe şeklinde iken, göğüs ve karın ağrısı şikayetleri ile başvuran olgularımız da mevcuttu.…”

Section: Discussionunclassified

Evaluation of Clinical and Laboratory Findings in Acute Benign Myositis in Childhood

Kaba¹,

Kendırcı²,

Demirbaş³

2022

jcp

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Giriş: Çocukluk çağının benign akut miyoziti (ÇÇABM) genellikle okul çağındaki çocukları etkileyen, simetrik baldır ağrısı ve ani olarak yürümeyi reddetme ile karakterize, kendiliğinden düzelebilen bir klinik tablodur ve kreatin fosfokinaz (CK) yüksekliği eşlik etmektedir. Çalışmamızın amacı ÇÇABM olgularımızın özelliklerinin ortaya konulmasıdır. Gereç ve Yöntem: Retrospektif olarak, hastanemiz Çocuk Acil Servis ve Çocuk Sağlığı ve Hastalıkları Polikliniklerine Ekim 2019 -Mart 2020 arasında üst solunum yolu enfeksiyonu ile başvuran ve ÇÇABM tanısı alan hastalar dahil edildi. Hastaların hastane bilgi yönetim sistemine kayıtlı takvim yaşı, hemogram, CRP, AST, ALT, LDH, CK, CK-MB düzeyleri değerlendirildi. İstatistiksel analizler IBM SPSS Statistics for Windows 22.0 yazılımı ile gerçekleştirildi. Bulgular: Ortalama yaşı 6,4±2,9 (5,0-12,9) yıl olan 52 olgunun %71,2'si (n=37) erkek cinsiyette idi. Hastaların %92,8'i (n=48) üst solunum yolu enfeksiyonunu (ÜSYE) takiben yürüyememe şikayeti ile başvururken, %5,8'i (n=3) ÜSYE ve karın ağrısı; %1,9'u (n=1) ÜSYE ve göğüs ağrısı şikayetiyle başvurmuştu. İlk başvuruda ölçülen ortalama serum CK düzeyi 1777,4±2320,5 (188-11383) IU/L olup, başvurunun 4. gününde ortalama 1104,3±1720,5 (81-7190) IU/L düzeyi ile anlamlı düşüş saptandı (p=0,011). Benzer şekilde AST, ALT, LDH düzeylerinde de 4. günde anlamlı düzelme gözlendi (p=0,053, p=0,001, p=0,043).Sonuç: Çalışmamızda ÇÇABM'nin erkek çocuklarda kızlara göre 2,4 kat daha sık görüldüğü, CK düzeyinin başvurunun 4. gününde anlamlı azaldığını saptadık. Başlangıç bulgularının ani ve hızlı olması nedeniyle endişe verici bir durum olsa da; kendiliğinden ve hızlı düzelen seyri, sekelsiz iyileşmeyle sonuçlanması nedeniyle benign bir tablo olduğu, bu süreçte gereksiz ve tekrarlayan tetkiklerden kaçınılması gerektiği akılda tutulmalıdır.

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“…Sporadic acute benign myositis is often caused by coxsackievirus, adenovirus, Epstein-Barr virus, mycoplasma and other noninfluenza viruses. [7][8][9][10][11] Acute benign myositis has been reported in 5.5% and 3.9% of children infected with influenza A and B viruses, respectively. 12 BACM related to influenza B virus infection has been commonly reported.…”

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confidence: 99%

Clinical Characteristics of 118 Pediatric Patients With Acute Benign Myositis Associated With Influenza A Virus Infection

Jiang,

Li,

Cao

et al. 2024

Pediatric Infectious Disease Journal

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Objective: The objective of this study was to investigate the clinical and laboratory features of acute benign myositis associated with influenza A virus infection in children. Methods: A retrospective analysis was performed on the clinical data of 118 children with acute benign myositis associated with influenza A virus infection who were admitted to the Children’s Hospital of Chongqing Medical University during the epidemic period of influenza A from February 2023 to May 2023. Results: (1) Most of the 118 children were preschool- or school-age. The most common symptom was sudden lower limb pain after fever, and bilateral calf myalgia was more common. The muscle enzyme spectrum ranged from 187.21 to 32191.00 μg/L (median: 3053 μg/L). Creatine kinase isoenzymes ranged from 5.15 to 749.7 μg/L (median 41.82 μg/L). Myoglobin ranged from 102.79 to 1200 μg/L (median 674.9 μg/L). (3) Examination: electromyography, muscle color Doppler ultrasound, radiograph and cardiac color Doppler ultrasound in Benign acute childhood myositis in children were rarely positive. (4) Treatment and prognosis: besides bed rest and a reduction of physical activity, oseltamivir treatment, drugs to improve energy metabolism, fluid replacement and alkalinization of symptomatic treatment. All children had a good prognosis without sequelae. Conclusions: This study summarized and analyzed the clinical characteristics of acute benign myositis associated with influenza A infection in children with the aim of allowing rapid and early diagnosis of the disease and reducing unnecessary diagnostic tests and treatments. Closely monitoring myalgia and the muscle enzyme spectrum is recommended to exclude other neuromuscular and metabolic diseases.

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Benign Acute Childhood Myositis: Our Experience on Clinical Evaluation

Cited by 7 publications

References 26 publications

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Evaluation of Clinical and Laboratory Findings in Acute Benign Myositis in Childhood

Clinical Characteristics of 118 Pediatric Patients With Acute Benign Myositis Associated With Influenza A Virus Infection

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