Benign Metastasizing Leiomyoma

Sapmaz, Feride; Ergin, Makbule; Katrancioglu, Ozgur; Gönlügür, Tanseli; Gönlügür, Uğur; Elagöz, Şahande

doi:10.1007/s00408-008-9084-8

Cited by 15 publications

(12 citation statements)

References 3 publications

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“…Most BML lesions remain constant in size; however a small percentage display an aggressive course. 3,4) As most BML stain positive for estrogen and progesterone receptors, as in our case, hormone involvement in the progression of the lesions is likely. 3,9,10) In conclusion, BML is a borderline tumor with benign histologic features, in spite of its biological behavior suggesting malignancy.…”

Section: Discussionmentioning

confidence: 55%

“…1,2) Although these lesions are slow-growing and asymptomatic and are usually incidentally diagnosed, they may cause debilitating symptoms and even life-threatening complications. 3,4) The small number of cases described in the literature and uncertainties regarding the optimal treatment and progression of the condition have promoted the publication of new reports. Here, we present a case of pulmonary BML.…”

Section: Introductionmentioning

confidence: 99%

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Benign Metastasizing Leiomyoma of the Lung

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Maeshima

Akanabe

et al. 2012

Ann Thorac Cardiovasc Surg

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A 44-year-old woman was found to have an abnormal shadow on a chest X-ray during a regular health checkup, and visited our department. Chest computed tomography showed multiple nodular shadows in both lungs. The patient had no history of neoplasm except for myomectomy for uterine leiomyoma 6 years previously. Eighteen months later, the nodules showed a gradual increase in size, and video-assisted thoracoscopic biopsy of a nodule was performed. Histopathologically, the pulmonary nodule was composed of benign smooth muscle cells proliferating in fascicles, consistent with the diagnosis of benign metastasizing leiomyoma. Benign metastasizing leiomyoma is defined as a histologically benign uterine smooth muscle tumor that acts in a somewhat malignant fashion and produces benign metastases. Although it is a rare condition, it should be considered in asymptomatic women of reproductive age with a history of uterine leiomyoma, who present with solitary or multiple pulmonary nodules. Herein, we report a case of pulmonary benign metastasizing leiomyoma.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Benign Metastasizing Leiomyoma of the Lung

Goto

Maeshima

Akanabe

et al. 2012

Ann Thorac Cardiovasc Surg

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“…Pulmonary lesions are bilateral in 70%, unilateral in 17% and solitary in 13% of cases. The average survival after pulmonary resection is 94 months (1,6). In our case, the patient had undergone a myomectomy 16 years earlier and total abdominal hysterectomy 14 years before the recurrence.…”

Section: Discussionmentioning

confidence: 74%

Pulmonary benign metastasizing leiomyoma: an extremely rare case

Agackiran¹,

Fındık²,

Üstün³

et al. 2014

TJPATH

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Benign metastasizing leiomyoma is typically seen in young premenopausal women after a mean period of 15 years following uterine leiomyoma or hysterectomy surgery. They are usually incidentally seen on chest x-rays and are nodular lesions that appear as bilateral nodules with a benign appearance and consist of smooth muscle proliferation. A 44-year-old female presented at her healthcare institution for backache for the last 9 months. Multiple nodules (largest 15 mm) scattered in both lungs and consistent with metastases were detected on computed tomography. The PET-CT results revealed multiple nodular densities with increased metabolic activity (SuVmax: 1.92) in both lungs, with the largest one measuring approximately 15 mm and located in the lower lobe superior segment of the right lung. A benign metastasizing leiomyoma was diagnosed with open wedge biopsy of the lung. We present this case due to its interesting clinical presentation and rarity and emphasize the pathogenesis.

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“…BML is a rare manifestation of the benign and common condition of uterine leiomyomas [8]. This term is used to describe multiple benign leiomyomas that appear several months to many years after hysterectomy for fibroids [4,9,10]. Women who have undergone hysterectomy for leiomyomas are the most commonly affected and are usually asymptomatic at presentation [2,11].…”

Section: Discussionmentioning

confidence: 99%

“…The masses rarely cavitate [4,8,9]. Unusual appearances of metastasising leiomyomas include cyst formation [8], tiny calcifications [9], dissemination in a miliary pattern [2,12], interstitial lung disease [4,12], pneumothorax [8,10] and pericardial effusion [12].…”

Section: Discussionmentioning

confidence: 99%

Large pulmonary masses containing varicose veins: a rare presentation of benign metastasising leiomyomas

Challa

Irion²,

Hochhegger³

et al. 2010

BJR

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ABSTRACT.A 48-year-old woman presented with cough and chest pain. A chest radiograph and CT scans showed bilateral lung masses containing massive venous varices. A core biopsy specimen revealed benign metastasising leiomyoma with strong expression of progesterone receptors. A review of her medical history revealed a hysterectomy 11 years earlier. The lung masses showed significant reduction in size after induction of artificial menopause, although the pulmonary varices persisted. A pulmonary varix is a localised enlargement of a segment of a pulmonary vein [1]. Lung varices have been associated with mitral valve disease, tuberculosis, emphysema, systemic hypertension and arteriovenous fistulae. Benign metastasising leiomyoma (BML) is a rare condition characterised by the presence of histologically benign smooth muscle tumours at extra-uterine sites in the presence of uterine leiomyomas [2][3][4]. Pelvic varices are a common finding in patients with uterine leiomyomas (fibroids); however, varices do not normally occur within the leiomyomas. We report CT findings observed in a 48-year-old woman who developed large varices inside BML lung masses. To our knowledge, this finding has not been previously described in the literature. Case reportA 48-year-old woman was referred for CT evaluation of pulmonary abnormalities that had appeared on a chest radiograph. She initially presented with a cough and pleuritic chest pain on the right side. Her medical history included a hysterectomy for fibroids 11 years earlier. On examination, she was clearly unwell and had a fever. A chest radiograph showed bilateral volume loss with bilateral indistinct hemidiaphragm and a possible mass in the left lower zone (Figure 1). She was hypoxic in room air. Routine haematological tests were unremarkable except for a C-reactive protein level that increased from 31 to 244 mg L 21. An electrocardiogram was unremarkable and D-dimer and troponin T levels were normal.A multislice CT scan of the chest with injection of intravenous contrast medium was performed. The resulting images demonstrated bilateral lung masses up to 9 cm in diameter with obvious venous varices. Vein diameters were as large as 1.2 cm in the lung cortex (Figure 2). Images of the lung varices were demonstrated by CT angiography three-dimensional reconstructions using maximum intensity projection (MIP) and volumerendering techniques (Figure 3).A CT-guided biopsy of the left lung lesion was performed, targeting the less vascularised area. Histological sections showed bland, predominantly fusiform, cells displaying no mitotic activity and arranged in a whorled pattern, typical of leiomyoma. These results were confirmed by immunolabelling for smooth muscle actin (SMA). Cell nuclei strongly expressed the receptor protein for progesterone, but not the oestrogen receptor, indicating that the cells might be responsive to hormonal manipulation. These features are diagnostic of BML. The patient was treated by inducing artificial menopause, which resulted in partial regression of the lun...

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Benign Metastasizing Leiomyoma

Cited by 15 publications

References 3 publications

Benign Metastasizing Leiomyoma of the Lung

Benign Metastasizing Leiomyoma of the Lung

Pulmonary benign metastasizing leiomyoma: an extremely rare case

Large pulmonary masses containing varicose veins: a rare presentation of benign metastasising leiomyomas

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