Benzocaine-modified maleic anhydride-cyclohexyl-1,3-dioxepin copolymer: preparation and potential medical applications

Uglea, Constantin V.; Vatajanu, Alina; Offenberg, H.; Grecianu, A.; Ottenbrite, Raphael M.

doi:10.1016/0032-3861(93)90405-y

Cited by 12 publications

(4 citation statements)

References 4 publications

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“…The copolymer was isolated by Ðltration and washed several times with water to remove NaCl traces, then dried in vacuum at 50¡C. 3 Titration of the dicarboxylic acid was carried out using 0É1 N solution of NaOH in the presence of phenolphthalein. 12 The percentage sodium uptake is given by the relationship :…”

Section: Copolymer Synthesismentioning

confidence: 99%

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Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene

et al. 1997

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A series of maleic anhydride (MA)–vinyl acetate (VA), MA–methyl methacrylate (MM) and MA–styrene (S) copolymers were prepared and characterized. By employing various amounts of initiator, MA–VA, MA–MM and MA–S copolymers with molecular weights ranging between 18 000 and 219 000 were obtained. The ‘in vivo’ and ‘in vitro’ tests performed on K562 cellular cultures (human chronic myeloid leukaemia) and also on Westar rats (inoculated with the Walker 256 carcinosarcome) showed that, as a function of the molecular weight, the copolymers synthesized had a 50% in vitro cytotoxicity and a mean tumour regression of a maximum of 68%. © 1997 SCI.

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Section: Copolymer Synthesismentioning

confidence: 99%

“…The action of MA copolymers as mitotic inhibitors, their functional role in neoplastic processes and in immunology, and their resistance to viruses have been reported. 2,3 Since MA copolymers yield polymers with a consistent 1 : 1 alternating structure, they have been synthesized for biological evaluation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene

et al. 1997

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“…Maleic anhydride (MA) is a kind of unique monomer because it does not readily undergo homopolymerization, but forms copolymers without any difficulty 1. MA copolymers exhibit various biological activities, which utility in mitotic inhibitors, neoplastic processes, and immunology and resistance to viruses have been reported 2, 3. Recent studies on St/MA copolymer (PSM) have also shown that it behaves as a compatibilizer of the montmorillonite filler4–6 as well as cured epoxy particles used as organic fillers 7–9…”

Section: Introductionmentioning

confidence: 99%

Investigation of stabilizer‐free dispersion polymerization process of styrene and maleic anhydride copolymer microspheres

Liang¹,

Meng²,

Jiang³

et al. 2010

J. Polym. Sci. A Polym. Chem.

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The copolymer microspheres of styrene (St) and maleic anhydride (MA) were synthesized by stabilizer-free dispersion polymerization, and the polymerization process was explored in detail. The results showed that the homopolymerization of St formed in initial polymerization period served as stabilizer, and reaction solvent of closer solubility parameter would benefit the stabilizer-free dispersion polymerization. In addition, some principal factors affecting the microspheres size, such as reaction time, reaction temperature, monomer concentration, molar feed ratio, reaction media, and cosolvent, were investigated as well. V C 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 5652-5658, 2010

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“…These materials were developed to produce a polymer chain with a high density of carboxyl groups and a biodegradable backbone. However, this modified polysaccharide had a limited antiviral and antitumor activity [7,8].…”

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confidence: 99%

Polyanionic Polymers. I. Synthesis, Characterization, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose

Uglea

Albu

Vatajanu

et al. 1994

Journal of Bioactive and Compatible Polymers

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New polymers with antiviral and antitumor activity were syn thesized by introducing benzocaine onto carboxymethylcellulose (CMC) or ox idized carboxymethylcellulose (oxidized CMC). The biological tests (anesthetic, antiviral and antitumor activity) showed that the introduction of benzocaine as a spacer between the main chain and a CMC carboxylic group enhances the an tiviral and antitumor activity of the CMC. The anesthetic effect of benzocaine- modified CMC indicates that benzocaine is not released by hydrolysis from the macromolecular support.

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Benzocaine-modified maleic anhydride-cyclohexyl-1,3-dioxepin copolymer: preparation and potential medical applications

Cited by 12 publications

References 4 publications

Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene

Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene

Investigation of stabilizer‐free dispersion polymerization process of styrene and maleic anhydride copolymer microspheres

Polyanionic Polymers. I. Synthesis, Characterization, and Potential Medical Applications of Benzocaine Modified Carboxymethylcellulose

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