�ber einen Fall von ?Agammaglobulin�mie? und das Verhalten parenteral zugef�hrten radioaktiv markierten Gammaglobulins im Serum

Hypogammaglobulinaemia and Pernicious Anaemia

“…It has been convincingly proved by Lang et al (30) that hypogammaglobulinaemia is due to deficient production of gamma-globulins and after it had been demonstrated by G ood et al that skin transplants took in patients with hypogammaglobulinaemia, attempts have been made by G ood et al and M artin et al to transplant lymph nodes to such patients (16,17,18,41), but the effect on the production of im munoglobulins was only transitory because the lymph nodes sloughed after some months. Therefore, routine treatment still consists of parenteral injection of gammaglobulins.…”

“…Larsson/Hagclquist/Costcr 51 might also question whether the name agammaglobulinaemia or hypogammaglobulinaemia really is adequate, since G itlin et al have shown that in these conditions there is also a reduction of two beta-globulins (13,14) and since the absence of isohaemagglutinins, one third of which belong to the electrophoretic beta-globulin frac tion (30), is regarded as a criterion of hypogammaglobulinaemia (5,9,49,62). Young et al (64) have also claimed that the defect should preferably be described as immunoglobulin deficiency, and Barandun et al (3,4) have called the condition AntikorpcrMangelsyndrom.…”

“…In the adult form of hypogammaglobulinaemia changes gener ally occur in the picture of the peripheral blood and in the reticulo endothelial system, in the latter in the form of enlargement of spleen, liver or lymph nodes (8,19,30,41,62) which sometimes show a sarcoidosis-like picture (65), but also that of a less specific granulomatosis (50) or a diffuse reticuloendothelial hyperplasia (17), which may be compensatory (19). The haematologic changes that have attracted most attention arc leukopenia and lympho penia, but decreased erythropoiesis is common in the form of postinfectious anaemia (27).…”

Transplantation Studies in Patients With Agammaglobulinemia

“…Studies by Gitlir1,2~ Young, Wolfson, and Cohnjg Lang el a1., 26 are due to failure of formation of gamma globulin rather than to increased loss or inordinately rapid destruction of this protein constituent. For example, in 3 of our cases where the survival of gamma globulin has been estimated by zinc turbidity, electrophoresis, and immunochemical technique, the half life of this compound has varied between 28 and 34 days.…”

“…Definition of the immunological handicap. Studies in numerous laboratories," 91 26 including our 21, 26 have established the nature of the immunological handicap in these patients. Our own observations have been fivefold and may be summarized as follows:…”